dr. J.K. (Janette) Burgess, PhD

Research

Research interests

Janette Burgess is a Rosalind Franklin Fellow, recently arrived from Australia, who is excited to have joined the Department of Pathology and Medical Biology, Medical Biology section at UMCG.  Janette completed her Bachelor of Science (with honours) at the University of Adelaide in 1991 and her PhD at the University of New South Wales in 1998.  In 1999 she was appointed to a Post-doctoral position at the University of Sydney under the guidance of Prof Judy Black.  She has been awarded a National Health and Medical Research Council (NHMRC) (Australia) Peter Doherty training award (2000-2006), NHMRC R.D Wright Career Development Award (2006-2011) and a NHMRC Career Development Fellowship level 2 (2012-2015).

Janette’s research focusses on the role of the extracellular matrix (ECM) in lung pathology.  She is intrigued by the changes in the tissue and airway structures of the lungs that occur during disease development and progression and wants to know if these changes are a cause or a consequence of the pathology.  Working with primary human cells, human lung tissue samples and patient clinical information, the research seeks to characterize the changes in the ECM that occur during disease in the lungs and to understand the mechanisms that underlie these changes.  By novel in vitro cell models, ex vivo human lung tissue models and advanced microscopy imaging techniques she is unraveling the complex nature of the regulation of the ECM and exploring its potential as a future target for therapeutic intervention. This research links basic science to the goods of prevention and treatment of human lung diseases that afflict millions of people worldwide.

Publications
  1. Greater cellular stiffness in fibroblasts from patients with idiopathic pulmonary fibrosis

    Jaffar, J., Yang, S-H., Kim, S. Y., Kim, H-W., Faiz, A., Chrzanowski, W. & Burgess, J. K. 8-Mar-2018 In : American Journal of Physiology - Lung Cellular and Molecular Physiology.

    Research output: Contribution to journalArticle

  2. Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling

    Wang, J., Faiz, A., Ge, Q., Vermeulen, C. J., Van der Velden, J., Snibson, K. J., van de Velde, R., Sawant, S., Xenaki, D., Oliver, B., Timens, W., Ten Hacken, N., van den Berge, M., James, A., Elliot, J. G., Dong, L., Burgess, J. K. & Ashton, A. W. 7-Mar-2018 In : Journal of cellular and molecular medicine. 12 p.

    Research output: Contribution to journalArticle

  3. Phenotype and Functional Features of Human Telomerase Reverse Transcriptase Immortalized Human Airway Smooth Muscle Cells from Asthmatic and Non-Asthmatic Donors

    Burgess, J. K., Ketheson, A., Faiz, A., Rempel, K. A. L., Oliver, B. G., Ward, J. P. T. & Halayko, A. J. 16-Jan-2018 In : Scientific Reports. 8, 12 p., 805

    Research output: Contribution to journalArticle

  4. Correction: Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis (doi: 10.1242/dmm.030114)

    Tjin, G., White, E. S., Faiz, A., Sicard, D., Tschumperlin, D. J., Mahar, A., Kable, E. P. W. & Burgess, J. K. 19-Dec-2017 In : Disease models & mechanisms. 10, 12, p. 1545

    Research output: Contribution to journalArticle

  5. Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis

    Tjin, G., White, E. S., Faiz, A., Sicard, D., Tschumperlin, D. J., Mahar, A., Kable, E. P. W. & Burgess, J. K. 1-Nov-2017 In : Disease models & mechanisms. 10, 11, p. 1301-1312 12 p.

    Research output: Contribution to journalArticle

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Activities
  1. American Journal of Physiology (External organisation)

    Burgess, J. (Member)
    Jan-2012Sep-2015

    Activity: ScientificMembership of board

  2. European Respiratory Society (ERS) (External organisation)

    Burgess, J. (Member)
    2018 → …

    Activity: ProfessionalMembership of network

  3. European Respiratory Society (ERS) (External organisation)

    Burgess, J. (Member)
    2017 → …

    Activity: ProfessionalMembership of committee

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