prof. dr. J.K. (Janette) Burgess

Research

Research interests

Janette Burgess is a Rosalind Franklin Fellow, recently arrived from Australia, who is excited to have joined the Department of Pathology and Medical Biology, Medical Biology section at UMCG.  Janette completed her Bachelor of Science (with honours) at the University of Adelaide in 1991 and her PhD at the University of New South Wales in 1998.  In 1999 she was appointed to a Post-doctoral position at the University of Sydney under the guidance of Prof Judy Black.  She has been awarded a National Health and Medical Research Council (NHMRC) (Australia) Peter Doherty training award (2000-2006), NHMRC R.D Wright Career Development Award (2006-2011) and a NHMRC Career Development Fellowship level 2 (2012-2015).

Janette’s research focusses on the role of the extracellular matrix (ECM) in lung pathology.  She is intrigued by the changes in the tissue and airway structures of the lungs that occur during disease development and progression and wants to know if these changes are a cause or a consequence of the pathology.  Working with primary human cells, human lung tissue samples and patient clinical information, the research seeks to characterize the changes in the ECM that occur during disease in the lungs and to understand the mechanisms that underlie these changes.  By novel in vitro cell models, ex vivo human lung tissue models and advanced microscopy imaging techniques she is unraveling the complex nature of the regulation of the ECM and exploring its potential as a future target for therapeutic intervention. This research links basic science to the goods of prevention and treatment of human lung diseases that afflict millions of people worldwide.

Publications
  1. Profiling of healthy and asthmatic airway smooth muscle cells following IL-1β treatment: A novel role for CCL20 in chronic mucus hyper-secretion

    Faiz, A., Weckmann, M., Tasena, H., Vermeulen, C. J., Van den Berge, M., Ten Hacken, N. H. T., Halayko, A. J., Ward, J. P. T., Lee, T. H., Tjin, G., Black, J. L., Haghi, M., Xu, C-J., King, G. G., Farah, C. S., Oliver, B. G., Heijink, I. H. & Burgess, J. K. 25-Jun-2018 In : European Respiratory Journal. 45 p.

    Research output: Contribution to journalArticle

  2. Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

    Waters, D. W., Blokland, K. E. C., Pathinayake, P. S., Burgess, J. K., Mutsaers, S. E., Prêle, C. M., Schuliga, M., Grainge, C. L. & Knight, D. A. 26-Apr-2018 In : American Journal of Physiology - Lung Cellular and Molecular Physiology.

    Research output: Contribution to journalArticle

  3. Serological neo-epitope extracellular matrix related markers reflecting collagen or elastin degradation are elevated in a mouse model of allergic asthma exacerbation

    Weckmann, M., Rønnow, S., Bülow-Sand, J. M., Wegmann, M., Lunding, L., Burgess, J., Bahmer, T., Leeming, D. J. & Kopp, M. V. 1-Feb-2018 In : Atemwegs- und Lungenkrankheiten. 44, 2, p. 85-86 2 p.

    Research output: Contribution to journalArticle

  4. Greater cellular stiffness in fibroblasts from patients with idiopathic pulmonary fibrosis

    Jaffar, J., Yang, S-H., Kim, S. Y., Kim, H-W., Faiz, A., Chrzanowski, W. & Burgess, J. K. 8-Mar-2018 In : American Journal of Physiology - Lung Cellular and Molecular Physiology.

    Research output: Contribution to journalArticle

  5. Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling

    Wang, J., Faiz, A., Ge, Q., Vermeulen, C. J., Van der Velden, J., Snibson, K. J., van de Velde, R., Sawant, S., Xenaki, D., Oliver, B., Timens, W., Ten Hacken, N., van den Berge, M., James, A., Elliot, J. G., Dong, L., Burgess, J. K. & Ashton, A. W. May-2018 In : Journal of cellular and molecular medicine. 22, 5, p. 2826-2837 12 p.

    Research output: Contribution to journalArticle

View all (130) »

Activities
  1. American Journal of Physiology (External organisation)

    Burgess, J. (Member)
    Jan-2012Sep-2015

    Activity: ScientificMembership of board

  2. European Respiratory Society (ERS) (External organisation)

    Burgess, J. (Member)
    2018 → …

    Activity: ProfessionalMembership of network

  3. European Respiratory Society (ERS) (External organisation)

    Burgess, J. (Member)
    2017 → …

    Activity: ProfessionalMembership of committee

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