prof. dr. J.K. (Janette) Burgess
Research
Research interests
Janette Burgess is a Rosalind Franklin Fellow, originally from Australia, who is excited to have joined the Department of Pathology and Medical Biology, Medical Biology section at UMCG. Janette completed her Bachelor of Science (with honours) at the University of Adelaide in 1991 and her PhD at the University of New South Wales in 1998. In 1999 she was appointed to a Post-doctoral position at the University of Sydney under the guidance of Prof Judy Black. She has been awarded a National Health and Medical Research Council (NHMRC) (Australia) Peter Doherty training award (2000-2006), NHMRC R.D Wright Career Development Award (2006-2011) and a NHMRC Career Development Fellowship level 2 (2012-2015).
Janette’s research focusses on the role of the extracellular matrix (ECM) in lung pathology. She is intrigued by the changes in the tissue and airway structures of the lungs that occur during disease development and progression and wants to know if these changes are a cause or a consequence of the pathology. Working with primary human cells, human lung tissue samples and patient clinical information, the research seeks to characterize the changes in the ECM that occur during disease in the lungs and to understand the mechanisms that underlie these changes. By novel in vitro cell models, ex vivo human lung tissue models and advanced microscopy imaging techniques she is unraveling the complex nature of the regulation of the ECM and exploring its potential as a future target for therapeutic intervention. This research links basic science to the goods of prevention and treatment of human lung diseases that afflict millions of people worldwide.
Publications
STAT3 Regulates the Onset of Oxidant-Induced Senescence in Lung Fibroblasts
Waters, D. W., Blokland, K. E. C., Pathinayake, P. S., Wei, L., Schuliga, M., Jaffar, J., Westall, G. P., Hansbro, P. M., Prele, C. M., Mutsaers, S. E., Bartlett, N. W., Burgess, J. K., Grainge, C. L. & Knight, D. A. 4-Jan-2019 In : American Journal of Respiratory Cell and Molecular Biology.Research output: Contribution to journal › Article
Unique Mechanisms of Connective Tissue Growth Factor Regulation in Airway Smooth Muscle in Asthma: Relationship with Airway Remodelling
Burgess, J. K., Wang, J., Faiz, A., Ge, Q., Vermeulen, C. J., Snibson, K., Oliver, B. G. G., Timens, W., Hacken, N. H., Van den Berge, M., James, A. L., Elliot, J., Dong, L. & Ashton, A. W. 2018 In : American Journal of Respiratory and Critical Care Medicine. 197, 2 p.Research output: Contribution to journal › Meeting Abstract
Fibrotic Lung Matrix Directs Changes in Extracellular Matrix Production by Lung Fibroblasts Which Is Countered by Adipose Tissue-Derived Stromal Cell Conditioned Media
van Os, L., Jonker, M. R., van den Toorn, T. L., Jellema, P., Moorlag, H., Harmsen, M. C., White, E. S., Heijink, I. H. & Burgess, J. K. 2018 In : American Journal of Respiratory and Critical Care Medicine. 197, 2 p.Research output: Contribution to journal › Meeting Abstract
Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts
Schuliga, M., Pechkovsky, D. V., Read, J., Waters, D. W., Blokland, K. E. C., Reid, A. T., Hogaboam, C. M., Khalil, N., Burgess, J. K., Prêle, C. M., Mutsaers, S. E., Jaffar, J., Westall, G., Grainge, C. & Knight, D. A. Dec-2018 In : Journal of cellular and molecular medicine. 22, 12, p. 5847-5861 15 p.Research output: Contribution to journal › Article
Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation
Nissen, G., Hollaender, H., Tang, F. S. M., Wegmann, M., Lunding, L., Vock, C., Bachmann, A., Lemmel, S., Bartels, R., Oliver, B. G., Burgess, J. K., Becker, T., Kopp, M. V. & Weckmann, M. 14-Sep-2018 In : Clinical and Experimental Allergy. 11 p.Research output: Contribution to journal › Article
Prizes
Lizotte Family Research Award for Interstitial Pulmonary Fibrosis Research
Janette Burgess (Recipient), 2014
Prize
Activities
American Journal of Physiology (External organisation)
Burgess, J. (Member)Jan-2012 → Sep-2015Activity: Scientific › Membership of board
European Respiratory Society (ERS) (External organisation)
Burgess, J. (Member)2018 → …Activity: Professional › Membership of network
European Respiratory Society (ERS) (External organisation)
Burgess, J. (Member)2017 → …Activity: Professional › Membership of committee
ID: 22837617