dr. J.F.M. (Job) van Boven
My multidisciplinary research team of physicians, pharmacists, nurses, sociologists, health technologists and health economists aims to optimize real-world drug outcomes and help people and society maximizing benefits from medicines. I have particular interest in personalized interventions and digital adherence technology to optimise the outcomes of drugs used to treat respiratory diseases (asthma, COPD, TB, CF, lung transplantation and lung cancer).
Research themes include:
(1) Identification of patient groups that could have clinical, environmental and/or economic benefit from optimization of medication use.
(2) Development, validation and usability testing of innovative devices (e.g. smartphone apps), tools and technologies such as digital inhalers and spacers, electronic pill bottles, injectables and smart blisters that monitor & support adherence.
(3) Clinical trials to assess the effectiveness and cost-effectiveness of (personalized) medication adherence enhancing tools, interventions and strategies in patients.
Current projects:
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MAECON: Medication Adherence Expertise Center Of the northern Netherlands (Founding Director)
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ENABLE: Chair of the European Network to Advance Best Practices & Technology on Medication Adherence (ENABLE) - COST Action Network of 40 countries (>200 members) to set up medication adherence expertise centers, review novel technologies, organize training schools, short-term fellowships & conferences (Action Chair; STSM awardees: Katerina Mantila, BPharm and Gaye Hafez, PharmD; funding: European Commission)
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ACCEPTANCE: Effectiveness and cost-effectiveness of a smart inhaler self-management program to enhance medication adherence in patients with asthma (PhD student: Susanne van de Hei, MD; funding: AstraZeneca)
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On TRACk: Randomised trial of intervention on incorporating TRaining, prepAration and Counseling to improve inhaler technique and medication adherence in patients with asthma and/or COPD (PhD student: Roland te Paske, MSc; funding: ZonMw)
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OUTER SPACE-2: Multi-center clinical trial to understand medication adherence and treatment response to biologics in patients with severe asthma using a digital spacer (PhD student: Amber Eikholt, MSc; funding: Trudell Medical)
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Expensive respiratory drug economics: Economic evaluations of novel hospital dispensed drugs for lung cancer and ILD (PhD student: Lotte Westerink, PharmD; funding: multisource)
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TAI Toolkit & shared decision making: The impact of shared decision making on asthma/COPD medication adherence and the development of a toolbox with evidence based, personalized adherence interventions following specific responses on the Test of Adherence to Inhalers (TAI) (PhD student: Maria Achterbosch, MSc, RN; funding: Chiesi)
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Stronger together: Development of a multidisciplinary patient journey for patients with lung cancer (Post-doc researcher: Annemieke Visser, PhD; funding: ZonMW)
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AURORA: Adherence and digital inhaler Utilization in a Registry to assess Outcomes in Real-world patients with Asthma (Researcher: Mechteld Wiertz, MD; funding: Novartis)
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CF Adherence: Enhancing medication adherence to oral cystic fibrosis medication (PhD student: Carina Hansen, PharmD)
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FUTURE: Fostering young people Under 25 with Tailored solutions to Use medication Responsibly and Effectively (PhD student: Minke Copinga, PharmD; funding: ZonMW)
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COPD LMIC: Personalised pharmacologic COPD treatment in low- and middle-income countries (PhD student: Patricia Alupo, MD)
Recently completed projects
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FRESH AIR: Horizon 2020 project focusing on the prevalence, burden and respiratory drug adherence in patients with chronic lung diseases in low and middle income countries Uganda, Kyrgyz Republic, Vietnam and Greece and the implementation of effective interventions (PhD student: Aizhamal Tabyshova, MD; funding: European Commission)
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Real-world data on adverse drug events and medication adherence in economic analyses of respiratory drugs (PhD student: Tanja Fens, PharmD; funding: multisource)
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Prominent: EU Marie Curie Cofund project on cost-effectiveness of personalized medicine (PhD student: Sajad Emamipour, MSc; funding: European Commission)
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Care pathway inhalation medication: Implementation assessment of the Dutch National Inhaler Care Pathway/LAN Zorgpad Inhalatiemedicatie (Researcher: Amber Eikholt, MSc; funding: Lung Alliance Netherlands)
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Smart TB pill bottle: Clinical trial to test a smart pill bottle connected with an app to support patients with medication adherence to TB drugs (Post-doc: Samiksha Ghimire, PhD; funding: Pill Connect)
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OUTER SPACE-1: Randomised controlled trial to assess the effects of a smart spacer supported educational intervention to enhance medication adherence in patients with asthma and/or COPD (PhD student: Boudewijn Dierick, MD; funding: Trudell Medical)
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Clinical pharmacy services for patients with tuberculosis (PhD student: Deni Iskandar, MPH; funding: Indonesian government-DIKTI scholarship)
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TAVI: Optimising tacrolimus therapy in patients with a lung transplantation by development of electronic drug adherence monitoring tools and assessment of long-term drug exposure in human scalp hair (PhD student: Tanja Zijp, PharmD; funding: Chiesi)
Output from recently completed projects related to respiratory diseases:
2024
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Augmenting clinical trials in asthma through digital technology, decentralised designs and patient-centric endpoints: opportunities and challenges (The Lancet Respiratory Medicine 2024)
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Cost-effectiveness and impact on healthcare utilization of interventions to improve medication adherence and outcomes in asthma and COPD: a systematic literature review (Journal of Allergy and Clinical Immunology: in Practice 2024)
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Ensuring availability of respiratory medicines in times of European drug shortages (European Respiratory Journal 2024)
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Does adding digital inhalers to asthma triple therapy result in quadruple therapy? (ERJ Open Research 2024)
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Pharmaceutical, clinical and regulatory challenges of reformulating pressurized metered-dose inhalers to reduce their environmental impact (Journal of Aerosol Medicine & Pulmonary Drug Delivery 2024)
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Usability and feasibility of the Test of Adherence to Inhalers (TAI) Toolkit in daily clinical practice: The BANANA study (npj Primary Care Respiratory Medicine 2024)
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An overview of adherence - what it is and why it is important (Journal of Allergy and Clinical Immunology: In Practice 2024)
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Overcoming challenges of managing chronic obstructive pulmonary disease in low- and middle-income countries (Expert Review of Respiratory Medicine 2024)
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Trends in NICE technology appraisals of non-small cell lung cancer drugs over the last decade (European Journal of Health Economics 2024)
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Reshaping respiratory care: potential advances in inhaled pharmacotherapy in asthma (Expert Opinion on Pharmacotherapy 2024)
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Medication adherence to CFTR modulators in patients with cystic fibrosis: a systematic review (European Respiratory Review 2024)
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Early diagnosis and treatment of COPD: the costs and benefits of case-finding (American Journal of Respiratory and Critical Care Medicine 2024)
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Digital inhaler implementation in daily asthma management: who, when and how? (Journal of Allergy and Clinical Immunology: in Practice 2024)
2023
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Long-term cost-effectiveness of digital inhaler adherence technologies in difficult-to-treat asthma (Journal of Allergy and Clinical Immunology: in Practice 2023)
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Digital Adherence Technologies in Tuberculosis (The Lancet Global Health 2023)
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Shared decision making and medication adherence in patients with COPD and/or asthma: the ANANAS study (Frontiers in Pharmacology 2023)
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Once- or twice-daily inhaler therapy for optimal adherence: “no-brainer” or shared decision? (Journal of Allergy and Clinical Immunology: in Practice 2023)
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Anticipated barriers and facilitators for implementing smart inhalers in asthma medication adherence management (npj Primary Care Respiratory Medicine 2023)
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Real-World Dispensing Patterns of Inhalation Medication in Young Adult Asthma: An Inception Cohort Study (Clinical Epidemiology 2023)
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Clinical Pharmacy Services for Tuberculosis management: a systematic review (Frontiers in Pharmacology 2023)
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Multidisciplinary tuberculosis care: leveraging the role of hospital pharmacists (BMJ Open Respiratory Research 2023)
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Electronic monitoring devices to support inhalation technique in patients with asthma: A Narrative Review (Current Treatment Options in Allergy 2023)
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Factors Associated with Patient Trust in the Pharmacy Team: Findings from a Mixed Method Study involving patients with Asthma & COPD (Patient Preference and Adherence 2023)
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Adult severe asthma registries: a global and growing inventory (Pragmatic and Observational Research 2023)
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Bedaquiline exposure in people with drug-resistant Tb treated for diabetes: analysis of two phase 2 trials (International Journal of Tuberculosis and Lung Disease 2023)
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Implementation of digital home monitoring of respiratory disease and management (Current Opinion in Pulmonary Medicine 2023)
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Clinical and economic burden of drug-susceptible tuberculosis in Indonesia: national trends 2017-19 (The Lancet Global Health 2023)
2022
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Combining digital adherence technology and therapeutic drug monitoring for personalized TB care (European Respiratory Journal 2022)
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Triple therapy of asthma - permutations and combinations (Journal of Allergy & Clinical Immunology: In Practice 2022)
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Suboptimal peak inspiratory flow and critical inhalation errors are associated with higher COPD-related healthcare costs (International Journal of COPD 2022)
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Towards precision drug therapy in asthma (Annals of Translational Medicine 2022)
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Digital spacer data driven COPD inhaler adherence education: the OUTERSPACE proof-of-concept study (Respiratory Medicine 2022)
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An Inca trail to the holy grail: digital medication adherence support for TB care (International Journal of Tuberculosis and Lung Disease 2022)
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Electronic inhaler monitoring (EIM) for chronic airways disease: Development and application of a Multi-Dimensional Efficacy Framework (Journal of Allergy & Clinical Immunology: In Practice 2022)
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Pharmacology, drug deposition and drug administration techniques of intranasal corticosteroids for treating allergic rhinitis (Clinical & Experimental Allergy 2022)
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Medication availability and economic barriers to adherence in asthma and COPD patients in low-resource settings (npj Primary Care Respiratory Medicine 2022)
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A pharmacy-based eHealth intervention promoting correct use of medication in patients with asthma and COPD: non-randomized pre-post study (Journal of Medical Internet Research 2022)
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Digital Health Technologies to Improve Medication Adherence and Treatment Outcomes in Tuberculosis Patients: A Systematic Review of Randomized Controlled Studies (Journal of Medical Internet Research 2022)
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Digital medication adherence technology: towards personalised TB care (International Journal of Tuberculosis and Lung Disease 2022)
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Cost-effectiveness of nintedanib for patients with progressive fibrosing interstitial lung disease (PF-ILD) (Pharmacoeconomics Open 2022)
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Prioritising primary care respiratory research needs: results from the 2020 International Primary Care Respiratory Group (IPCRG) global e-Delphi exercise (npj Primary Care Respiratory Medicine 2022)
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Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma (Journal of Allergy & Clinical Immunology: In Practice 2022)
2021
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When biology meets behaviour: can medication adherence mask the contribution of pharmacogenetic effects in asthma? (European Respiratory Journal 2021)
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Personalizing medication adherence management in asthma and COPD: a review of effective interventions and development of a practical toolkit (Journal of Allergy & Clinical Immunology: In Practice 2021)
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Maximising Adherence and Gaining New Information For Your Chronic Obstructive Pulmonary Disease (MAGNIFY COPD): Study Protocol for the Pragmatic, Cluster Randomised Trial Evaluating the Impact of Dual Bronchodilator with Add-on Sensor and Electronic Monitoring on Clinical Outcomes (Pragmatic and Observational Research 2021)
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Global burden of medication non-adherence in COPD and asthma: a narrative review of the clinical and economic case for smart inhalers (Journal of Thoracic Disease 2021)
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Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade (Journal of Global Health 2021)
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Risk of Neuropsychiatric Adverse Events Associated with Varenicline Treatment for Smoking Cessation among Dutch Population: A Sequence Symmetry Analysis (Pharmacoepidemiology & Drug Safety 2021)
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Work absence in patients with asthma/COPD: a population-based study (npj Primary Care Respiratory Medicine 2021)
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GINA 2020: Potential impacts, opportunities and challenges for primary care (Journal of Allergy & Clinical Immunology: In Practice 2021)
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Impact of blood eosinophil variability in asthma: a real-life population study (Annals of the American Thoracic Society 2021)
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Impact of socioeconomic status on adult patients with asthma: a population-based cohort study from UK primary care (Journal of Asthma and Allergy 2021)
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Clinical characteristics, treatment patterns and economic burden of COPD in Kyrgyzstan: a FRESH AIR study (International Journal of Chronic Obstructive Pulmonary Disease 2021)
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Strategies for the Prevention, Diagnosis and Treatment of COPD in Low- and Middle- Income Countries: the Importance of Primary Care (Expert Review of Respiratory Medicine 2021)
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Challenges in the Implementation of COPD Guidelines in Low- and Middle-Income Countries: an ATS Workshop Report (Annals of the American Thoracic Society 2021)
2020
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Trajectories analyses of adherence patterns in a real-life moderate to severe asthma population (Journal of Allergy & Clinical Immunology: In Practice 2020)
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Interventions to improve medication adherence in tuberculosis patients: a systematic review of randomized controlled studies (npj Prim Care Respir Med 2020)
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Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease study 2017 (The Lancet Respiratory Medicine 2020)
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Improving adherence to treatment in COPD. A personalised approach (Respiratory Medicine Today 2020)
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Clinical and economic impact of medication non-adherence in drug susceptible tuberculosis: systematic review (International Journal of Tuberculosis and Lung Disease 2020)
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Switching inhalers: a practical approach to keep on UR RADAR (Pulmonary Therapy 2020)
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Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy (Expert Review of Pharmacoeconomics & Outcomes Research 2020)
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Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper (Clinical and Translational Allergy 2020)
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Spacers and valved holding chambers-the risk of switching to different chambers (Journal of Allergy & Clinical Immunology: In Practice 2020)
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Prevalence and economic burden of respiratory diseases in Central Asia and Russia: a systematic review (Int J Environ Res Public Health 2020)
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Let's stop dumping cookstoves in local communities: it's time to get implementation right! (npj Primary Care Respiratory Medicine 2020)
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Influence of age of real-life effects of doxycycline for acute exacerbations among COPD outpatients: a population-based cohort study (BMJ Open Respiratory Research 2020)
2019
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Does changing inhaler devices impact real-life asthma outcomes?: Clinical and economic evaluation (Journal of Allergy & Clinical Immunology: In Practice 2019)
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Making sense of cost-effectiveness analysis in respiratory medicine: a practical guide for non-health economists (European Respiratory Journal 2019)
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The hidden story of nonadherence with asthma therapy: for a few dollars more? (Journal of Allergy & Clinical Immunology: In Practice 2019)
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Effects and acceptability of implementing improved cookstoves and heaters to reduce household air pollution: a FRESH AIR study (npj Primary Care Respiratory Medicine 2019)
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Prevalence and characteristics of asthma-COPD overlap in routine primary care practices (Annals of the American Thoracic Society 2019)
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COPD's early origins in low-and-middle-income countries: what are the implications of a false start? (npj Primar Care Respiratory Medicine 2019)
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Development of the International Severe Asthma Registry: a modified Delphi study (Journal of Allergy & Clinical Immunology: In Practice 2019)
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Diabetes mellitus comorbidity in patients enrolled in tuberculosis drug efficacy trials around the world: a systematic review (British Journal of Clinical Pharmacology 2019)
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High COPD prevalence at high altitude: does household air pollution play a role? (European Respiratory Journal 2019)
2018
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The clinical impact of different adherence behaviours in patients with severe COPD (American Journal of Respiratory and Critical Care Medicine 2018)
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Addressing the impact and unmet needs of non-adherence in asthma and COPD: where do we go from here? (Journal of Allergy & Clinical Immunology: In Practice 2018)
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Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: a multinational point prevalence study of hospitalised patients (European Respiratory Journal 2018)
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Personalising adherence enhancing interventions using a smart inhaler in patients with COPD: an exploratory cost-effectiveness analysis (npj Primary Care Respiratory Medicine 2018)
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Asthma cost-effectiveness analyses: are we using the recommended outcomes in estimating value? (Journal of Allergy & Clinical Immunology: In Practice 2018)
2017
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Costly comorbidities of COPD: the ignored side of the coin? (European Respiratory Journal 2017)
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Electric scooters: batteries in the battle against ambient air pollution? (The Lancet Planetary Health 2017)
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Does co-payment for inhaler devices affect therapy adherence and disease outcomes? A historical matched cohort study (Pragmatic & Observational Research 2017)
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Effectiveness and success factors of educational interventions on inhalation technique in asthma & COPD: a systematic review (npj Primary Care Respiratory Medicine 2017)
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Clinical characteristics, treatment patterns and socio-economic burden of COPD in Bulgaria (Journal of Medical Economics 2017)
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Optimizing identification and management of COPD patients - reviewing the role of the community pharmacist (British Journal of Clinical Pharmacology 2017)
2016
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COPD case finding: effective, but also cost-effective? (The Lancet Respiratory Medicine 2016)
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What we mean when we talk about adherence in respiratory medicine (The Journal of Allergy and Clinical Immunology: In Practice 2016)
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Hollywood raising awareness of smoking-related diseases: can it proactively counteract the impact of smoking in movies? – the final mission of Star Trek’s Mr. Spock (npj Primary Care Respiratory Medicine 2016)
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Enhancing respiratory medication adherence: the role of healthcare professionals and cost-effectiveness considerations (The Journal of Allergy and Clinical Immunology: In Practice 2016)
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Factors associated with the prescription of inhaled corticosteroids in primary care patients with COPD: a cross-sectional study in the Balearic Islands (Spain) (European Journal of General Practice 2016)
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Increasing research capacity and awareness of chronic lung diseases in East Africa (The Lancet Global Health blog 2016)
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Enhancing the use of asthma and COPD assessment tools in Balearic primary care (npj Prim Care Respir Med 2016)
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Effects of targeted disease and medication management interventions towards patients with COPD (Curr Med Res Opin 2016)
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Higher adherence during reimbursement of pharmacologic smoking cessation treatments (Nicotine & Tobacco Research 2016)
2015
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Predictors of cost-effectiveness of selected COPD treatments in primary care: UNLOCK study protocol (npj Prim Care Respir Med 2015)
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Towards tailored and targeted adherence assessment to optimise asthma management (npj Prim Care Respir Med 2015)
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Mapping the Clinical COPD Questionnaire (CCQ) onto generic preference-based EQ-5D values (Value in Health 2015)
2014
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Clinical and economic impact of non-adherence in patients with COPD: a systematic review (Respiratory Medicine 2014)
2013
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Effects of targeted pharmaceutical care in patients with asthma and COPD: results of a pilot study (Pharmaceutisch Weekblad 2013)
Global Burden of Disease
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Global Alliance for Chronic Disease researchers' statement on multimorbidity (Lancet Global Health 2018)
Effectiveness and cost-effectiveness of real-world drug optimization in chronic diseases
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Barriers and Unmet Educational Needs Regarding Implementation of Medication Adherence Management Across Europe: Insights from COST Action ENABLE (Journal of General Internal Medicine 2024)
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Pan-European survey on medication adherence management by healthcare professionals (British Journal of Clinical Pharmacology 2024)
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Patient-reported medication related problems, adherence and waste of oral anticancer medication over time (European Journal of Hospital Pharmacy 2024)
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New terminology of medication adherence enabling and supporting activities: ENABLE terminology (Frontiers in Pharmacology 2023)
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The impact of trust in healthcare and medication, and beliefs about medication on medication adherence in a Dutch medication-using population (Journal of Psychosomatic Research 2023)
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Self-Reported Adherence Instruments and their Applicability in Low-Middle Income Countries: a scoping review (Frontiers in Public Health 2023)
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Medication adherence measurement methods in registration trials supporting the approval of new medicines in the European Union 2010-2020 (Clinical Pharmacology & Therapeutics 2022)
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Electronic smart blister packages to monitor and support medication adherence: a usability study (Patient Preference & Adherence 2022)
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Swiss priority setting on implementing medication adherence interventions as part of COST Action ENABLE (International Journal of Public Health 2022)
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Reimbursed medication adherence enhancing interventions in 12 European countries: current state of the art and future challenges (Frontiers in Pharmacology 2022)
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Editorial: Digital Tools to Measure and Promote Medication Adherence (Frontiers in Medical Technology 2021)
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European Network to Advance Best practices & technoLogy on medication adherencE (ENABLE): Mission Statement (Frontiers in Pharmacology 2021)
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Disparities in European healthcare system approaches to maintaining continuity of medication for non-communicable diseases during the COVID-19 outbreak (The Lancet Regional Health - Europe 2021)
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User Acceptability and Technical Robustness Evaluation of a Novel Smart Pill Bottle Prototype Designed to Support Medication Adherence (Patient Preference & Adherence 2020)
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Effects, costs and implementation of monitoring kidney transplant patients' tacrolimus level with dried blood spot sampling: a randomised controlled hybrid implementation trial (British Journal of Clinical Pharmacology 2020)
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HbA1c response after insulin initiation in patients with type 2 diabetes in real-life: identifying distinct subgroups (Diabetes, Obesity and Metabolism 2018)
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Proactive pharmaceutical care interventions decrease patients' nonadherence to osteoporosis medication (Osteoporosis International 2014)
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Persistence with osteoporosis medication among newly-treated osteoporotic patients (J Bone Miner Metab 2013)
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Proactive pharmaceutical care interventions improve patients' adherence to lipid-lowering medication (Annals Pharmacotherapy 2013)
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Cost-effectiveness of improving adherence to bisphosphonates therapy in patients with osteoporosis (Pharmaceutisch Weekblad 2011)
Last modified: | 08 November 2024 09.57 a.m. |