dr. J.F.M. (Job) van Boven

Associate Professor

Faculty of Medical Sciences

Telephone:

+31 50 361 7893

+31 50 361 4087 (fax)

E-mail:

j.f.m.van.boven rug.nl

ORCID Research Portal

My multidisciplinary research team of physicians, pharmacists, nurses, sociologists, health technologists and health economists aims to optimize real-world drug outcomes and help people and society maximizing benefits from medicines. I have particular interest in personalized interventions and digital adherence technology to optimise the outcomes of drugs used to treat respiratory diseases (asthma, COPD, TB, CF, lung transplantation and lung cancer).

Research themes include:

(1) Identification of patient groups that could have clinical, environmental and/or economic benefit from optimization of medication use.

(2) Development, validation and usability testing of innovative devices (e.g. smartphone apps), tools and technologies such as digital inhalers and spacers, electronic pill bottles, injectables and smart blisters that monitor & support adherence.

(3) Clinical trials to assess the effectiveness and cost-effectiveness of (personalized) medication adherence enhancing tools, interventions and strategies in patients.

Current projects:

MAECON: Medication Adherence Expertise Center Of the northern Netherlands (Role: Founding Director)
CONNECT: Moving multiple digital innovations towards connected respiratory care: addressing the over-arching challenges of whole systems implementation (Funding: European Respiratory Society; Role: Co-Chair of ERS CRC CONNECT)
On TRACk: Randomised trial of intervention on incorporating TRaining, prepAration and Counseling to improve inhaler technique and medication adherence in patients with asthma and/or COPD (PhD student: Roland te Paske, MSc; funding: ZonMw)
OUTER SPACE-2: Multi-center clinical trial to understand medication adherence and treatment response to biologics in patients with severe asthma using a digital spacer (PhD student: Amber Eikholt, MSc; funding: Trudell Medical)
Expensive respiratory drug economics: Economic evaluations of novel hospital dispensed drugs for lung cancer and ILD (PhD student: Lotte Westerink, PharmD; funding: multisource)
TAI Toolkit & shared decision making: The impact of shared decision making on asthma/COPD medication adherence and the development of a toolbox with evidence based, personalized adherence interventions following specific responses on the Test of Adherence to Inhalers (TAI) (PhD student: Maria Achterbosch, MSc, RN; funding: Chiesi)
AURORA: Adherence and digital inhaler Utilization in a Registry to assess Outcomes in Real-world patients with Asthma (Researcher: Mechteld Wiertz, MD; funding: Novartis)
CF Adherence: Enhancing medication adherence to oral cystic fibrosis medication (PhD student: Carina Hansen, PharmD)
FUTURE: Fostering young people Under 25 with Tailored solutions to Use medication Responsibly and Effectively (PhD student: Minke Copinga, PharmD; funding: ZonMW)
COPD LMIC: Personalised pharmacologic COPD treatment in low- and middle-income countries (PhD student: Patricia Alupo, MD)
COPD-ALERT: Prediction of COPD exacerbations through artificial intelligence based monitoring of medication adherence and other real-world medical data
Optimising medication use and outcomes post lung transplantation (PhD student: Marel Schelders, PharmD)
CAREPATH: Collaborative Action and Research for Engagement, Persistence and Adherence in Treatment & Health (Post-docs: Zinzi Pardoel, PhD and Rimke Vos, PhD; funding: European Commission IHI)

Recently completed projects

FRESH AIR: Horizon 2020 project focusing on the prevalence, burden and respiratory drug adherence in patients with chronic lung diseases in low and middle income countries Uganda, Kyrgyz Republic, Vietnam and Greece and the implementation of effective interventions (PhD student: Aizhamal Tabyshova, MD; funding: European Commission)
Real-world data on adverse drug events and medication adherence in economic analyses of respiratory drugs (PhD student: Tanja Fens, PharmD; funding: multisource)
Prominent: EU Marie Curie Cofund project on cost-effectiveness of personalized medicine (PhD student: Sajad Emamipour, MSc; funding: European Commission)
Care pathway inhalation medication: Implementation assessment of the Dutch National Inhaler Care Pathway/LAN Zorgpad Inhalatiemedicatie (Researcher: Amber Eikholt, MSc; funding: Lung Alliance Netherlands)
Smart TB pill bottle: Clinical trial to test a smart pill bottle connected with an app to support patients with medication adherence to TB drugs (Post-doc: Samiksha Ghimire, PhD; funding: Pill Connect)
OUTER SPACE-1: Randomised controlled trial to assess the effects of a smart spacer supported educational intervention to enhance medication adherence in patients with asthma and/or COPD (PhD student: Boudewijn Dierick, MD; funding: Trudell Medical)
Clinical pharmacy services for patients with tuberculosis (PhD student: Deni Iskandar, MPH; funding: Indonesian government-DIKTI scholarship)
TAVI: Optimising tacrolimus therapy in patients with a lung transplantation by development of electronic drug adherence monitoring tools and assessment of long-term drug exposure in human scalp hair (PhD student: Tanja Zijp, PharmD; funding: Chiesi)
Stronger together: Development of a multidisciplinary patient journey for patients with lung cancer (Post-doc researcher: Annemieke Visser, PhD; funding: ZonMW)
ENABLE: Chair of the European Network to Advance Best Practices & Technology on Medication Adherence (ENABLE) - COST Action Network of 40 countries (>200 members) to set up medication adherence expertise centers, review novel technologies, organize training schools, short-term fellowships & conferences (Action Chair; STSM awardees hosted: Katerina Mantila, BPharm, Gaye Hafez, PharmD and Nilay Aksoy, PhD, funding: European Commission)
ACCEPTANCE: Effectiveness and cost-effectiveness of a smart inhaler self-management program to enhance medication adherence in patients with asthma (PhD student: Susanne van de Hei, MD; funding: AstraZeneca)