prof. dr. J.D.A. (Jocelien) Olivier

Assistant Professor

prof. dr. J.D.A. (Jocelien) Olivier


Research units:

Research interests


Our translational animal research is focused on the neurodevelopmental outcomes due to early life alterations. Interactions between genes and the environment play an important role in the development of psychopathology. It is our main goal to address the developmental role of serotonin in developing psychopathology later in life using an advanced animal model for depression (serotonin transporter knockout rat). To address the fundamental issues that underlie alterations due to early life events, we attempt to identify molecular mechanisms underlying these alterations.


Effects of antenatal depression and antidepressant treatment during pregnancy

Depressive symptoms frequently occur during pregnancy and may have a tremendous impact on the developing child. Unfortunately, pharmacological antidepressant treatments during pregnancy can also negatively impact the behavioural development and health of the offspring. In humans it is difficult to discern between the effects of the drug and the effects of the depression itself, therefore it is unclear whether children exposed to antidepressants in utero are at increased risk, and if so, what the underlying molecular mechanisms are that may point to potential solutions. We investigate the molecular mechanisms and behavioral alterations in the offspring that are altered due to antenatal depression, antidepressant treatment during pregnancy, and their combination.



We conduct extensive behavioural experimentation (Emotional, social, sleep and cognition), Physiology (telemetry), pharmacological manipulations (SSRIs), immunohistochemical assessments and molecular analysis (microarray, qPCR, genotyping, DNA methylation, DNA hydroxymethylation, histone methylation).

  1. Antidepressant treatment with fluoxetine during pregnancy and lactation modulates the gut microbiome and metabolome in a rat model relevant to depression

    Ramsteijn, A. S., Jašarević, E., Houwing, D. J., Bale, T. L. & Olivier, J. DA., 23-Jan-2020, In : Gut Microbes. p. 1-19 19 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. The effect of antenatal depression and antidepressant treatment on placental tissue: A protein-validated gene expression study

    Edvinsson, Å., Hellgren, C., Kunovac Kallak, T., Åkerud, H., Skalkidou, A., Stener-Victorin, E., Fornes, R., Spigset, O., Lager, S., Olivier, J. & Sundström-Poromaa, I., 5-Dec-2019, In : BMC Pregnancy and Childbirth. 19, 1, 479.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Perinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environment

    Houwing, D. J., Heijkoop, R., Olivier, J. D. A. & Snoeren, E. M. S., Jun-2019, In : Neuropharmacology. 151, p. 84-97

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Subjecting dams to early life stress and perinatal fluoxetine treatment differentially alters social behavior in young and adult rat offspring

    Houwing, D. J., Staal, L., Swart, J. M., Ramsteijn, A. S., Woehr, M., de Boer, S. F. & Olivier, J. D. A., 12-Mar-2019, In : Frontiers in Neuroscience. 13, 15 p., 229.

    Research output: Contribution to journalArticleAcademicpeer-review

  5. Constitutive serotonin transporter reduction resembles maternal separation with regard to stress-related gene expression

    Comasco, E., Schijven, D., de Maeyer, H., Vrettou, M., Nylander, I., Sundström-Poromaa, I. & Olivier, J. DA., 17-Jul-2019, In : ACS chemical neuroscience. 10, p. 3132-3142

    Research output: Contribution to journalArticleAcademicpeer-review

View all (55) »

Press / Media
  1. 1 op de 5 zwangere vrouwen krijgt depressie-klachten, mogen zij antidepressiva?

    Jocelien Olivier


    1 Media contribution

    Press/Media: Public Engagement ActivitiesPopular

  2. De Universiteit van Noorderzon

    Jocelien Olivier, Ward Rauws, Warner Hoornenborg, Lilian Peters, Stella Weiland, Wanda Douwenga, Andrea Cabrera Arreola & Anton Scheurink


    4 items of Media coverage

    Press/Media: Public Engagement ActivitiesPopular

  3. Honderden gebreide neuronen vormen kunstwerk

    Jocelien Olivier, Maaike de Heij & Romy Smit


    1 item of Media coverage, 1 Media contribution

    Press/Media: Public Engagement ActivitiesPopular

View all (6) »

  1. Universiteit van Noorderzon

    Jocelien Olivier (Organiser), Ward Rauws (Organiser)

    Activity: Participating in or organising an eventOrganising an eventPopular

  2. Community Art – Neural Knitworks

    Jocelien Olivier (Advisor), Wanda Douwenga (Advisor)

    Activity: ConsultancyOutreachPopular

  3. Zenuw-achtig wol

    Jocelien Olivier (Advisor), Wanda Douwenga (Advisor)

    Activity: ConsultancyOutreachPopular

View all (14) »

  1. Young Academy Groningen (YAG)

    Jocelien Olivier (Recipient), 2018

    Prize: Election to learned societyAcademic

  2. NARSAD Young Investigator Grant

    Jocelien Olivier (Recipient), 2016

    Prize: Fellowship awarded competitivelyAcademic

  3. Marie Sklodowska Curie Individual Fellowship

    Jocelien Olivier (Recipient), 1-May-2015

    Prize: Fellowship awarded competitivelyAcademic

View all (3) »

View graph of relations

ID: 13014973