dr. J. (Jaap) Broos

Associate professor

Faculty of Science and Engineering

Telephone:

+31 50 36 34277

E-mail:

j.broos rug.nl

Homepage Research Portal

Publications

Functionalizing Nisin with a Sugar Moiety Improves Its Solubility and Results in an Altered Antibacterial Spectrum and Mode of Action

Guo, L., Kuipers, O. P. & Broos, J., Oct-2025, In: ACS Synthetic Biology. 14, 9, p. 3568-3577 10 p., acssynbio.5c00353.

Research output: Contribution to journal › Article › Academic › peer-review

Heterologous Expression and Characterization of Estercin A, a Class II Lanthipeptide Derived from Clostridium estertheticum CF016, with Antimicrobial Activity against Clinically Relevant Pathogens.

Wang, C., Wambui, J., Fernandez-Cantos, M. V., Jurt, S., Broos, J., Stephan, R. & Kuipers, O. P., 15-Jan-2025, (E-pub ahead of print) In: Journal of Natural Products. 12 p., 4c00814.

Research output: Contribution to journal › Article › Academic › peer-review

Synthesis and Antimicrobial Specificities of Halogenated Tryptophan-Containing Nisin Variants

Wang, C., Tervoort, S., Kuipers, O. P. & Broos, J., Oct-2025, In: ACS chemical biology. 20, 10, p. 2503-2511 9 p., 5c00632.

Research output: Contribution to journal › Article › Academic › peer-review

Altering Specificity and Enhancing Stability of the Antimicrobial Peptides Nisin and Rombocin through Dehydrated Amino Acid Residue Engineering

Guo, L., Stoffels, K., Broos, J. & Kuipers, O. P., Apr-2024, In: Peptides. 174, 26 p., 171152.

Research output: Contribution to journal › Article › Academic › peer-review

An Engineered Nisin Analogue with a Hydrophobic Moiety Attached at Position 17 Selectively Inhibits Enterococcus faecium Strains.

Guo, L., Kuipers, O. P. & Broos, J., 20-Sept-2024, In: ACS chemical biology. 19, 9, p. 2023-2031 9 p., 4c00337.

Research output: Contribution to journal › Article › Academic › peer-review

Engineering hybrid lantibiotics yields the highly stable and bacteriocidal peptide cerocin V

Guo, L., Stoffels, K., Broos, J. & Kuipers, O. P., May-2024, In: Microbiological Research. 282, 11 p., 127640.

Research output: Contribution to journal › Article › Academic › peer-review

Facile Halogenation of Antimicrobial Peptides As Demonstrated by Producing Bromotryptophan-Labeled Nisin Variants with Enhanced Antimicrobial Activity

Guo, L., Kuipers, O. P. & Broos, J., 28-Jun-2024, In: Journal of Natural Products. 87, 6, p. 1548-1555 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Rombocin, a Short Stable Natural Nisin Variant, Displays Selective Antimicrobial Activity against Listeria monocytogenes and Employs a Dual Mode of Action to Kill Target Bacterial Strains.

Guo, L., Wambui, J., Wang, C., Broos, J., Stephan, R. & Kuipers, O. P., 19-Jan-2024, In: ACS Synthetic Biology. 13, 1, p. 370–383 15 p., 3c00612.

Research output: Contribution to journal › Article › Academic › peer-review

Cesin, a short natural variant of nisin, displays potent antimicrobial activity against major pathogens despite lacking two C-terminal macrocycles

Guo, L., Wambui, J., Wang, C., Muchaamba, F., Fernandez-Cantos, M. V., Broos, J., Tasara, T., Kuipers, O. P. & Stephan, R., Oct-2023, In: Microbiology Spectrum. 11, 5, 21 p., e0531922.

Research output: Contribution to journal › Article › Academic › peer-review

Lipidated variants of the antimicrobial peptide nisin produced via incorporation of methionine analogs for click chemistry show improved bioactivity

Guo, L., Wang, C., Broos, J. & Kuipers, O. P., Jul-2023, In: The Journal of Biological Chemistry. 229, 7, 12 p., 104845.

Research output: Contribution to journal › Article › Academic › peer-review

All (81) publications

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