dr. J. (Jaap) Broos

UHD

Faculteit Science and Engineering

Telefoon:

050 36 34277

E-mail:

j.broos rug.nl

Homepage Research Portal

Publicaties

Functionalizing Nisin with a Sugar Moiety Improves Its Solubility and Results in an Altered Antibacterial Spectrum and Mode of Action

Guo, L., Kuipers, O. P. & Broos, J., 19-sep-2025, In: ACS Synthetic Biology. 14, 9, blz. 3568-3577 10 blz., acssynbio.5c00353.

Onderzoeksoutput › › peer review

Heterologous Expression and Characterization of Estercin A, a Class II Lanthipeptide Derived from Clostridium estertheticum CF016, with Antimicrobial Activity against Clinically Relevant Pathogens.

Wang, C., Wambui, J., Fernandez-Cantos, M. V., Jurt, S., Broos, J., Stephan, R. & Kuipers, O. P., feb-2025, In: Journal of Natural Products. 88, 2, blz. 262–273 12 blz., 4c00814.

Onderzoeksoutput › › peer review

Synthesis and Antimicrobial Specificities of Halogenated Tryptophan-Containing Nisin Variants

Wang, C., Tervoort, S., Kuipers, O. P. & Broos, J., 17-okt-2025, In: ACS chemical biology. 20, 10, blz. 2503-2511 9 blz., 5c00632.

Onderzoeksoutput › › peer review

Altering Specificity and Enhancing Stability of the Antimicrobial Peptides Nisin and Rombocin through Dehydrated Amino Acid Residue Engineering

Guo, L., Stoffels, K., Broos, J. & Kuipers, O. P., apr-2024, In: Peptides. 174, 26 blz., 171152.

Onderzoeksoutput › › peer review

An Engineered Nisin Analogue with a Hydrophobic Moiety Attached at Position 17 Selectively Inhibits Enterococcus faecium Strains.

Guo, L., Kuipers, O. P. & Broos, J., 20-sep-2024, In: ACS chemical biology. 19, 9, blz. 2023-2031 9 blz., 4c00337.

Onderzoeksoutput › › peer review

Engineering hybrid lantibiotics yields the highly stable and bacteriocidal peptide cerocin V

Guo, L., Stoffels, K., Broos, J. & Kuipers, O. P., mei-2024, In: Microbiological Research. 282, 11 blz., 127640.

Onderzoeksoutput › › peer review

Facile Halogenation of Antimicrobial Peptides As Demonstrated by Producing Bromotryptophan-Labeled Nisin Variants with Enhanced Antimicrobial Activity

Guo, L., Kuipers, O. P. & Broos, J., 28-jun-2024, In: Journal of Natural Products. 87, 6, blz. 1548-1555 8 blz.

Onderzoeksoutput › › peer review

Rombocin, a Short Stable Natural Nisin Variant, Displays Selective Antimicrobial Activity against Listeria monocytogenes and Employs a Dual Mode of Action to Kill Target Bacterial Strains.

Guo, L., Wambui, J., Wang, C., Broos, J., Stephan, R. & Kuipers, O. P., 19-jan-2024, In: ACS Synthetic Biology. 13, 1, blz. 370–383 15 blz., 3c00612.

Onderzoeksoutput › › peer review

Cesin, a short natural variant of nisin, displays potent antimicrobial activity against major pathogens despite lacking two C-terminal macrocycles

Guo, L., Wambui, J., Wang, C., Muchaamba, F., Fernandez-Cantos, M. V., Broos, J., Tasara, T., Kuipers, O. P. & Stephan, R., okt-2023, In: Microbiology Spectrum. 11, 5, 21 blz., e0531922.

Onderzoeksoutput › › peer review