dr. J. (Jaap) Broos

UHD

Faculteit Science and Engineering

Telefoon:

050 36 34277

E-mail:

j.broos rug.nl

Homepage Research Portal

Publicaties

Functionalizing Nisin with a Sugar Moiety Improves Its Solubility and Results in an Altered Antibacterial Spectrum and Mode of Action

Guo, L., Kuipers, O. P. & Broos, J., 12-aug.-2025, (E-pub ahead of print) In: ACS Synthetic Biology. 10 blz., acssynbio.5c00353.

Onderzoeksoutput: Article › › peer review

Heterologous Expression and Characterization of Estercin A, a Class II Lanthipeptide Derived from Clostridium estertheticum CF016, with Antimicrobial Activity against Clinically Relevant Pathogens.

Wang, C., Wambui, J., Fernandez-Cantos, M. V., Jurt, S., Broos, J., Stephan, R. & Kuipers, O. P., 15-jan.-2025, (E-pub ahead of print) In: Journal of Natural Products. 12 blz., 4c00814.

Onderzoeksoutput: Article › › peer review

Altering Specificity and Enhancing Stability of the Antimicrobial Peptides Nisin and Rombocin through Dehydrated Amino Acid Residue Engineering

Guo, L., Stoffels, K., Broos, J. & Kuipers, O. P., apr.-2024, In: Peptides. 174, 26 blz., 171152.

Onderzoeksoutput: Article › › peer review

An Engineered Nisin Analogue with a Hydrophobic Moiety Attached at Position 17 Selectively Inhibits Enterococcus faecium Strains.

Guo, L., Kuipers, O. P. & Broos, J., 20-sep.-2024, In: ACS chemical biology. 19, 9, blz. 2023-2031 9 blz., 4c00337.

Onderzoeksoutput: Article › › peer review

Engineering hybrid lantibiotics yields the highly stable and bacteriocidal peptide cerocin V

Guo, L., Stoffels, K., Broos, J. & Kuipers, O. P., mei-2024, In: Microbiological Research. 282, 11 blz., 127640.

Onderzoeksoutput: Article › › peer review

Facile Halogenation of Antimicrobial Peptides As Demonstrated by Producing Bromotryptophan-Labeled Nisin Variants with Enhanced Antimicrobial Activity

Guo, L., Kuipers, O. P. & Broos, J., 28-jun.-2024, In: Journal of Natural Products. 87, 6, blz. 1548-1555 8 blz.

Onderzoeksoutput: Article › › peer review

Rombocin, a Short Stable Natural Nisin Variant, Displays Selective Antimicrobial Activity against Listeria monocytogenes and Employs a Dual Mode of Action to Kill Target Bacterial Strains.

Guo, L., Wambui, J., Wang, C., Broos, J., Stephan, R. & Kuipers, O. P., 19-jan.-2024, In: ACS Synthetic Biology. 13, 1, blz. 370–383 15 blz., 3c00612.

Onderzoeksoutput: Article › › peer review

Cesin, a short natural variant of nisin, displays potent antimicrobial activity against major pathogens despite lacking two C-terminal macrocycles

Guo, L., Wambui, J., Wang, C., Muchaamba, F., Fernandez-Cantos, M. V., Broos, J., Tasara, T., Kuipers, O. P. & Stephan, R., okt.-2023, In: Microbiology Spectrum. 11, 5, 21 blz., e0531922.

Onderzoeksoutput: Article › › peer review

Lipidated variants of the antimicrobial peptide nisin produced via incorporation of methionine analogs for click chemistry show improved bioactivity

Guo, L., Wang, C., Broos, J. & Kuipers, O. P., jul.-2023, In: The Journal of Biological Chemistry. 229, 7, 12 blz., 104845.

Onderzoeksoutput: Article › › peer review

Probing the Conformational States of Thimet Oligopeptidase in Solution

Marcondes, M. F. M., Santos, G. S., Bronze, F., Machado, M. F. M., Perez, K. R., Hesselink, R., de Vries, M. P., Broos, J. & Oliveira, V., 1-jul.-2022, In: International Journal of Molecular Sciences. 23, 13, 18 blz., 7297.

Onderzoeksoutput: Article › › peer review

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