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How to find us I.A. (Izabela) Rodenhuis-Zybert

Research interests

My team within the Experimental Virology Group focuses on immune mechanisms triggered by acute viral infections. Specifically, we try to understand the mechanisms governing the differences between the balanced and unbalanced inflammation induced by the infections.  Currently, our primary goal is to identify points of control in inflammation in the course of dengue virus, chikungunya virus and SARS-CoV-2 infection. Importantly, through national and international collaborations with basic and clinical scientists, we foster the multidisciplinary approach to these infections.

Next to research, I enjoy teaching biology of viral infections. Herewith I hope to excite new generations to pursue science in the fields of virology and immunology.

Publications

Chikungunya virus requires an intact microtubule network for efficient viral genome delivery

Serotonergic Drugs Inhibit Chikungunya Virus Infection at Different Stages of the Cell Entry Pathway

TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

Tomatidine, a natural steroidal alkaloid shows antiviral activity towards chikungunya virus in vitro

Understanding immunopathology of severe dengue: lessons learnt from sepsis

Impaired Antibody-Independent Immune Response of B Cells in Patients With Acute Dengue Infection

Human macrophages differentiated in the presence of vitamin D3 restrict dengue virus infection and innate responses by downregulating mannose receptor expression

Suppression of chikungunya virus replication and differential innate responses of human peripheral blood mononuclear cells during co-infection with dengue virus

Altered immune response of immature dendritic cells upon dengue virus infection in the presence of specific antibodies

Dengue tropism for macrophages and dendritic cells: the host cell effect

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