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Over ons Praktische zaken Waar vindt u ons H.J. (Henk) Busscher
University Medical Center Groningen

H.J. (Henk) Busscher

Emeritus hoogleraar
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E-mail:
h.j.busscher umcg.nl

           CONDENSED CURRICULUM VITAE

                     

of                          :   HENDRIK JAN BUSSCHER

born                      :   24‑10‑1955

in                          :   GRONINGEN, THE NETHERLANDS

 

address, office     :   Department of Biomaterials and Biomedical Technology

                                 University Medical Center and University of Groningen

                                 Antonius Deusinglaan 1

                                 9713 AV GRONINGEN, THE NETHERLANDS

                                 http://www.rug.nl/research/biomaterials/

 e-mail                   :   h.j.busscher@umcg.nl

Research interests:    

- Physico-chemistry of the interactions of biological components

(proteins, cells, microorganisms) with materials, including

biomaterials and dental surfaces and biofilm community aspects.

- Prevention of biomaterial-associated infections through surface modification, as well as improved methods for       diagnosis of biomaterial-associated infection.

- Development of pathogenic biofilms on biomaterial surfaces and influences of antibiotics and probiotics.

- Characterization of biomaterial surfaces and coatings through physico-chemical techniques and mechanisms of microbial adhesion, required for the development of necessary therapeutic and prophylactic methods for biomaterials-associated infection.

- Design of animal studies for evaluating anti-infection strategies replacing clinical studies, and design of in vitro studies replacing animal experiments for evaluating anti-infection strategies.

- Prevention of infection of tissue-engineered constructs.

-Biomaterials implant retrieval for microbiological and surface analyses in orthopedics, ophthalmology, plastic surgery and otorhinolaryngology.

 Current positions    :

1.  Researcher at the Department of Biomaterials and Biomedical technology, University Medical Center and University of Groningen (appointed for 20%).

2.   Director-owner of a consulting company: Scientific and Applied Surface Advice.

3.   Editor: Colloids and Surfaces B: Biointerfaces

 

Conferences, memberships, numbers of papers and patents, PhD theses supervised:

- Conferences and Symposia Organized               :           14

- Memberships of Scientific Organizations           :             3

- Editorial board Memberships                           :             3

- Books and Journals Edited                              :            10

- Patents                                                         :             6

- Theses supervised                                         :          >120

- Full papers, including book chapters                :        >666

 

Web-of-Science Summary (Janyary 2024):

Number of articles, short notes, reviews and

proceeding papers in English               >666

Total number of citations                                                                                  35474 

Average number of citations per paper                                                          53.26

H-factor                                                                                                               92

 

Disclaimer:

  1. I’m the director-owner of a consulting company “Scientific and Applied Surface Advice”. SASA BV has been consulting for or is currently consulting for amongst others: ATOS Medical, Bausch & Lomb, Braun-Oral B, Colgate-Palmolive (pending), DePuy Orthopeadics, GABA International, Henkel AG, Philips Sonicare, Procter & Gamble, Straumann International, Wrigley.
  2. I have permission for my activities within SASA BV from the University of Groningen/ University Medical Center Groningen.
  3. I, nor SASA BV, have any financial interests in the companies that SASA BV consults for.
  4. My academic work has been directly funded by DSM, Ethicon, FCDF, Philips, SASA BV,  Zorginnovatie BV (pending).
  5. My academic work has furthermore been funded by IOP milieutechnologie / Zware Metalen, Senter, STW grants 07109, 07844, Eureka grants 72310, 2614, BMM-grant P4.01 NANTICO (BMM is a Dutch public-private partnership co-funded by the Dutch Ministry of Economic Affairs) and FP-7 project FORMAMP.

My academic work may have been directly or indirectly, but always unintentionally, influenced by (a) the companies that SASA BV has consulted for, (b) industrial partners that have directly funded my academic work or (c) industrial partners in the public-private partnerships related to the grants that fund my academic work. However, all opinions and assertions contained in my academic work are mine, i.e. those of my co-authors and are not construed as necessarily representing views of the funding organizations. 

 Ten land-mark papers over the past five years (per July 2021):

Title

Journal

Year

Volume

Beginning

Page

Ending page

Liposomes with Water as a pH-Responsive Functionality for Targeting

of Acidic Tumor and Infection Sites

ANGEWANDTE CHEMIE INT. EDITION

2021

60

2

8

Clearance of ESKAPE Pathogens from Blood Using Bacterially Activated Macrophage Membrane-Coated Silicon Nanowires

ADVANCED FUNCTIONAL MATERIALS

2021

31

 

 

Accepting higher morbidity in exchange for sacrificing fewer animals in studies developing novel infection-control strategies

BIOMATERIALS

2020

232

 

 

Self-targeting, zwitterionic micellar dispersants enhance antibiotic killing of infectious biofilms-An intravital imaging study in mice

SCIENCE ADVANCES

2020

6

 

 

Coating of a Novel Antimicrobial Nanoparticle with a Macrophage Membrane for the Selective Entry into Infected Macrophages and Killing of Intracellular Staphylococci

ADVANCED FUNCTIONAL MATERIALS

2020

30

 

 

Antifungal-Inbuilt Metal-Organic-Frameworks Eradicate Candida albicans Biofilms

ADVANCED FUNCTIONAL MATERIALS

2020

30

 

 

Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control

CHEMICAL SOCIETY REVIEWS

2019

48

428

446

Artificial Channels in an Infectious Biofilm Created by Magnetic Nanoparticles Enhanced Bacterial Killing by Antibiotics

SMALL

2019

15

 

 

Emergent heterogeneous microenvironments in biofilms: substratum surface heterogeneity and bacterial adhesion force-sensing

FEMS MICROBIOLOGY REVIEWS

2018

42

259

272

Physico-chemistry from initial bacterial adhesion to surface-programmed biofilm growth

ADVANCES IN COLLOID AND INTERFACE SCIENCE

2018

261

1

14

 

Ten most cited papers (per July 2021):

Title

Journal

Year

Volume

Beginning

Page

Total citations

Physico-chemistry of initial microbial adhesive interactions - its mechanisms and methods for study

FEMS MICROBIOLOGY REVIEWS

1999

23

179

818

Measurement of the surface free-energy of bacterial-cell surfaces and its relevance for adhesion

APPLIED AND ENVIRONMENTAL MICROBIOLOGY

1984

48

980

535

Biomaterial-Associated Infection: Locating the Finish Line in the Race for the Surface

SCIENCE TRANSLATIONAL MEDICINE

2012

4

 

400

The effect of surface roughening of polymers on measured contact angles of liquids

COLLOIDS AND SURFACES

1984

9

319

388

In vitro and in vivo antimicrobial activity of covalently coupled quaternary ammonium silane coatings on silicone rubber

BIOMATERIALS

2002

23

1417

353

Antimicrobial effects of positively charged surfaces on adhering Gram-positive and Gram-negative bacteria

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

2001

48

7

351

Electrochemical and surface characterization of a nickel-titanium alloy

BIOMATERIALS

1998

19

761

347

The influence of surface free-energy and surface-roughness on early plaque-formation - an in vivo study in man

JOURNAL OF CLINICAL PERIODONTOLOGY

1990

17

138

320

Electric double layer interactions in bacterial adhesion to surfaces

SURFACE SCIENCE REPORTS

2002

47

3

308

Specific and nonspecific interactions in bacterial adhesion to solid substrata

FEMS MICROBIOLOGY LETTERS

1987

46

165

305

 

Laatst gewijzigd:19 januari 2024 16:50