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About us Practical matters How to find us prof. dr. G.J. (Gerrit) Poelarends

prof. dr. G.J. (Gerrit) Poelarends

Professor of Pharmaceutical Biotechnology

Faculty of Science and Engineering

Telephone:

+31 50 36 33354

E-mail:

g.j.poelarends rug.nl

ORCID Research Portal

Publications

Biochemical, kinetic, and structural characterization of a Bacillus tequilensis nitroreductase

Russo, S., Rozeboom, H. J., Wijma, H. J., Poelarends, G. J. & Fraaije, M. W., 1-Jul-2024, (E-pub ahead of print) In: The FEBS Journal. 15 p., 17210.

Research output: Contribution to journal › Article › Academic › peer-review

Exploiting Nitroreductases for the Tailored Photoenzymatic Synthesis of Structurally Diverse Heterocyclic Compounds

Luján, A. P., Bhat, M. F., Marko, E. E. A., Fodran, P. & Poelarends, G. J., 16-Jul-2024, (E-pub ahead of print) In: Chemistry – A European Journal. 18 p., e202402380.

Research output: Contribution to journal › Article › Academic › peer-review

Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors

Zhao, C., Zhang, J., Zhou, H., Setroikromo, R., Poelarends, G. & Dekker, F., 1-Aug-2024, (E-pub ahead of print) In: Journal of Medicinal Chemistry.

Research output: Contribution to journal › Article › Academic › peer-review

Exploring the Substrate Scope and Catalytic Promiscuity of Nitroreductase‐like Enzymes

Prats Luján, A., Bhat, M. F., Thangavelu, S. & Poelarends, G., 29-Aug-2024, (E-pub ahead of print) In: Advanced Synthesis & Catalysis. 19 p., 202400220.

Research output: Contribution to journal › Article › Academic › peer-review

Multigram-scale chemoenzymatic synthesis of diverse aminopolycarboxylic acids as potential metallo-β-lactamase inhibitors

Bhat, M. F., Prats Luján, A., Saifuddin, M., Fodran, P. & Poelarends, G. J., 2024, In: Organic and Biomolecular Chemistry. 2024, 3, p. 491-495 5 p., 22.

Research output: Contribution to journal › Article › Academic › peer-review

Synthesis of Pharmaceutically Relevant Arylamines Enabled by a Nitroreductase from Bacillus tequilensis

Russo, S., Prats Luján, A., Fraaije, M. & Poelarends, G. J., 17-May-2024, In: ChemBioChem. 25, 10, 10 p., e202300846.

Research output: Contribution to journal › Article › Academic › peer-review

The synthesis of 1,2,3-triazoles as binders of D-dopachrome tautomerase (D-DT) for the development of dual-targeting inhibitors

Osipyan, A., Bulai, R. G., Wu, Z., de Witte, J., van der Velde, J. J. H., Kader, M., van der Wouden, P. E., Poelarends, G. J. & Dekker, F. J., 5-Oct-2024, In: European Journal of Medicinal Chemistry. 276, 116665.

Research output: Contribution to journal › Article › Academic › peer-review

Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos

Chen, D., Osipyan, A., Adriana, J., Kader, M., Gureev, M., Knol, C. W. J., Sigmund, M. C., Xiao, Z., van der Wouden, P. E., Cool, R. H., Poelarends, G. J. & Dekker, F. J., 13-Jul-2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8767-8781 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Biocatalytic Cascade Synthesis of Enantioenriched Epoxides and Triols from Biomass-Derived Synthons Driven by Specifically Designed Enzymes

Grandi, E., Crotti, M., Sigmund, M.-C., Xu, G., Tepper, P. G. & Poelarends, G. J., 2-Jun-2023, In: Chemistry. 29, 31, 8 p., e202300697.

Research output: Contribution to journal › Article › Academic › peer-review

Enzymatic Oxy- and Amino-Functionalization in Biocatalytic Cascade Synthesis: Recent Advances and Future Perspectives

Grandi, E., Özgen, F. F., Schmidt, S. & Poelarends, G. J., 27-Nov-2023, In: Angewandte Chemie (International ed. in English). 62, 48, 27 p., e202309012.

Research output: Contribution to journal › Article › Academic › peer-review

All (155) publications

Press/media

Poelarends and Sigmund publish Review Article in Nature Catalysis

Poelarends, G.

12/10/2020

Press/Media: Research › Popular

Poelarends and coworkers publish in Nature Catalysis

Poelarends, G.

15/03/2018

Press/Media: Research › Popular

Prestigious NWO VICI grant Poelarends

Poelarends, G.

17/02/2017

Press/Media: Other › Popular

Nature Communications paper: Klein enzym krijgt nieuwe functie

Poelarends, G.

08/03/2016

Press/Media: Research › Popular

Versimpelde synthesemethode versnelt neurobiologisch onderzoek

Poelarends, G.

24/02/2015

Press/Media: Research › Popular

Muteer je nuttig

Poelarends, G.

07/05/2012

Press/Media: Public Engagement Activities › Popular

Nieuwe enzymen voor de milieuvriendelijke productie van aminozuren

Poelarends, G.

04/05/2012

Press/Media: Research › Popular

All (7) press/media

View full research profile

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