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Rijksuniversiteit Groningenfounded in 1614  -  top 100 university
Over ons Praktische zaken Waar vindt u ons G.F.C. (Guillaume) Etter, Dr

Research interests

My research lies at the intersection of neuroscience and artificial intelligence and focuses on learning and memory in neural networks. In particular, I seek to uncover what are the microcircuit dynamics of excitatory and inhibitory neurons involved in updating synaptic weights between neurons to improve behaviors in freely moving animals. In turn, I apply state-of-the-art knowledge of biological neural networks to improve artificial intelligence models, notably with respect to learning incrementally (lifelong learing).

To achieve these objective, I use deep learning and reinforcement learning frameworks, as well as neurophysiological approaches (in vivo calcium imaging, electrophysiology, optogenetics).

Finally, I leverage both neuroscience and AI approaches to develop predictive methods and treatments for neurodegenerative disorders (including Alzheimer's disease).

Publicaties

Learning to combine top-down context and feed-forward representations under ambiguity with apical and basal dendrites

Idiothetic representations are modulated by availability of sensory inputs and task demands in the hippocampal-septal circuit

Structured and unstructured reactivations during REM sleep are modulated by novel experiences

Optogenetic frequency scrambling of hippocampal theta oscillations dissociates working memory retrieval from hippocampal spatiotemporal codes

Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model

A population code for idiothetic representations in the hippocampal-septal circuit

Theta band optogenetic stimulation of the septo-hippocampal fibres in the fornix reduces interictal spikes and rescues memory performance in hAPP-j20 mice

Linking temporal coordination of hippocampal activity to memory function

Optogenetic activation of septal inhibitory cells abates focal seizures

Bilateral optogenetic activation of inhibitory cells favors ictogenesis

Pers/media

Can Alzheimer's disease memory impairments be rescued?