prof. dr. F. (Folkert) Kuipers

Telefoon:

E-mail:

f.kuipers umcg.nl

Research interests

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

Publicaties

Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury

Attema, B. & Kuipers, F., mei-2025, In: EMBO Molecular Medicine. 17, 5, blz. 863-865 3 blz.

Onderzoeksoutput › › peer review

New insights in amino sugar metabolism by the gut microbiome

Shen, W., de Boer, J. F., Kuipers, F. & Fu, J., dec.-2025, In: Gut Microbes. 17, 1, 12 blz., 2510462.

Onderzoeksoutput › peer review

One probe fits all: a highly customizable modular RNA in situ hybridization platform expanding the application of SABER DNA probes

Ustyantsev, K., Stranges, M., Volpe, F. G., de Boer, J. F., Kuipers, F., Mouton, S. & Berezikov, E., jun.-2025, In: DEVELOPMENT. 152, 11, 11 blz., dev204775.

Onderzoeksoutput › › peer review

Role for the liver X receptor agonist 22-ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

Martens, N., Zhan, N., Yam, S. C., Palumbo, M., Pontini, L., Leijten, F. P. J., van Vark-van der Zee, L., Voortman, G., Friedrichs, S., Gerding, A., Marinozzi, M., Jonker, J. W., Kuipers, F., Lütjohann, D., Vanmierlo, T. & Mulder, M. T., 15-apr.-2025, (E-pub ahead of print) In: British Journal of Pharmacology. 23 blz.

Onderzoeksoutput › › peer review

SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis

Halmos, B., La Rose, A. M., Methorst, D., Groenen, A. G., Nakládal, D., Bazioti, V., Koster, M. H., Kloosterhuis, N. J., Buiten, A. V., Schouten, E. M., Huijkman, N. C. A., Langelaar-Makkinje, M., Bongiovanni, L., De Neck, S. M., de Bruin, A., Buikema, H., Deelman, L. E., van den Heuvel, M. C., Kuipers, F. & de Jong, I. J.& 4 anderen, Sluimer, J. C., Jørgensen, H. F., Henning, R. H. & Westerterp, M., 28-feb.-2025, In: Circulation Research. 136, 5, blz. 491-507 17 blz.

Onderzoeksoutput › › peer review

The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice

Yntema, T., Eijgenraam, T. R., Kloosterhuis, N. J., Havinga, R., Koster, M. H., Hovingh, M. V., de Boer, J. F., Koonen, D. P. Y. & Kuipers, F., 15-jan.-2025, In: Scientific Reports. 15, 1, 11 blz., 2100.

Onderzoeksoutput › › peer review

Therapeutic hyperthermia promotes lipid export and HSP70/90 during machine perfusion of human livers

Thorne, A. M., Geng, Y., Lantinga, V. A., Smit, M., Kuivenhoven, J. A., Porte, R. J., Kuipers, F., Olinga, P., Wolters, J. C. & de Meijer, V. E., 9-mei-2025, (E-pub ahead of print) In: Physiological Reports. 13, 9, 18 blz., e70348.

Onderzoeksoutput › › peer review

Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice

Heida, A., van Dijk, T., Smit, M., Koehorst, M., Koster, M., Kloosterhuis, N., Havinga, R., Bloks, V. W., Wolters, J. C., de Bruin, A., Kuivenhoven, J. A., de Boer, J. F., Kuipers, F. & van de Sluis, B., mrt.-2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 2, 11 blz., 159445.

Onderzoeksoutput › › peer review

Characterization of milk oligosaccharide and sialic acid content and their influence on brain sialic acid in a lean mouse model for gestational diabetes

Liu, F., Tol, A. J. C., Kuipers, F., Oosterveer, M. H., van der Beek, E. M. & van Leeuwen, S. S., 15-feb.-2024, In: Heliyon. 10, 3, 13 blz., e24539.

Onderzoeksoutput › › peer review

Comparative Analysis of Digestion Methods for Bile Proteomics: The Key to Unlocking Biliary Biomarker Potential

Thorne, A. M., Hoekzema, M., Porte, R. J., Kuipers, F., de Meijer, V. E. & Wolters, J. C., 2024, In: Analytical Chemistry. 96, 36, blz. 14393–14404 12 blz.

Onderzoeksoutput › › peer review