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How to find us prof. dr. F. (Folkert) Kuipers

Research interests

 

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

 

Publications

Altered bile acid kinetics contribute to postprandial hypoglycaemia after Roux-en-Y gastric bypass surgery

Emerging roles of bile acids in control of intestinal functions

Gut microbiome and bile acids in obesity-related diseases

Impaired VLDL catabolism links hypoglycemia to hypertriglyceridemia in GSD Ia

24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer's Disease

A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice[S]

An early-life diet containing large phospholipid-coated lipid globules programs later-life postabsorptive lipid trafficking in high-fat diet but not in low-fat dietfed mice

Blocking sodium-taurocholate cotransporting polypeptide stimulates biliary cholesterol and phospholipid secretion

Cholangiopathy and biliary fibrosis in Cyp2c70-deficient mice are fully reversed by ursodeoxycholic acid

Cholecystectomy increases the risk of dumping syndrome and postbariatric hypoglycemia after bariatric surgery

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Press/media

Journal News - From the Journals

De rol van het microbioom bij het ontstaan van hart- en vaatziekten