prof. dr. F. (Folkert) Kuipers

prof. dr. F. (Folkert) Kuipers
E-mail:
f.kuipers umcg.nl

Research

Research interests

 

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

 

Publications
  1. Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidemia and atherosclerosis development

    Zhou, E., Hoeke, G., Li, Z., Eibergen, A. C., Schonk, A. W., Koehorst, M., Boverhof, R., Havinga, R., Kuipers, F., Coskun, T., Boon, M. R., Groen, A. K., Rensen, P. C. N., Berbée, J. F. P. & Wang, Y., 2019, In : Cardiovascular Research.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. WHAT IS THE ORIGIN OF SEVERE HYPERCHOLESTEROLEMIA IN A LARGE COHORT OF EMIRATIS WITH A HIGH PREVALANCE OF TYPE 2 DIABETES

    Rimbert, A., Kuivenhoven, J. A., Lansberg, P., Viel, M., Kanninga, R., Johansson, L., Kuipers, F., Bloks, V., van Faassen, M., Koehorst, M., Sinke, R., Daggag, H., Al Tikriti, A. & Barakat, M. T., Aug-2019, In : ATHEROSCLEROSIS. 287, p. E198-E199 2 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  3. GENDER-SPECIFIC DIFFERENCES AT BOTH EXTREME ENDS OF THE LDL CHOLESTEROL DISTRIBUTION CURVE

    Rimbert, A., Balder, J. W., Zhang, X., Wolters, K., Lansberg, P., Viel, M., Kanninga, R., Johansson, L., Bloks, V., van Daasen, M., Koehorst, M., Kuipers, F., Sinke, R., Groen, A., Dallinga-Thie, G. & Kuivenhoven, J. A., Aug-2019, In : ATHEROSCLEROSIS. 287, p. E64 1 p.

    Research output: Contribution to journalMeeting AbstractAcademic

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