prof. dr. F. (Folkert) Kuipers

Telefoon:

E-mail:

f.kuipers umcg.nl

Research interests

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

Publicaties

Back to basics: Bile acids in fat absorption

Kuipers, F., Verkade, H. J. & Freark de Boer, J., 3-feb-2026, In: Cell Metabolism. 38, 2, blz. 249-251 3 blz.

Onderzoeksoutput › › peer review

Bile Acid Detergency as Determinant of Liver Pathology in a Humanized Mouse Model of Progressive Familial Intrahepatic Cholestasis Type 3

Ke, L., Mulder, N. L., Hovingh, M. V., Havinga, R., Weersing, E., de Vries, H. D., de Bruyn, K., Ustyantsev, K., Berezikov, E., Bloks, V. W., Attema, B., Worthmann, A., Heeren, J., Wolters, J. C., Tiessen-Thomas, R., Verkade, H. J., Kuipers, F. & de Boer, J. F., 2026, In: Cellular and molecular gastroenterology and hepatology. 20, 8, 22 blz., 101783.

Onderzoeksoutput › › peer review

Bile Acids and Healthy Ageing

Attema, B. & Kuipers, F., 2026, (Accepted/In press) In: Engineering. 11 blz.

Onderzoeksoutput › peer review

Connecting fragmented aging research through the European Federation for Aging Research

European Federation for Aging Research, Schumacher, B., Scheibye-Knudsen, M., Rasmussen, L. J. & Kuipers, F., jun-2026, In: Nature Aging. 6, blz. 1196–1197 2 blz.

Onderzoeksoutput ›

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70-Deficient Mice With a Human-Like Bile Acid Composition

de Vries, H. D., Li, J., Ustyantsev, K., Hovingh, M. V., Mulder, N. L., Havinga, R., Palmiotti, A., de Bruyn, K., Attema, B., Weersing, E., Thomas, R. E., Bloks, V. W., Berezikov, E., van Faassen, M., Verkade, H. J., de Boer, J. F. & Kuipers, F., mei-2026, In: Liver International. 46, 5, 16 blz., e70632.

Onderzoeksoutput › › peer review

Generation and characterization of a mouse model for bile salt export pump deficiency with the p.E297G mutation

Felzen, A., Hof, W. F. J., de Vries, H., Hovingh, M. V., Havinga, R., Mulder, N. L., Koehorst, M., Kloosterhuis, N., Smit, M., Huijkman, N., van de Sluis, B., de Boer, J. F., Kuipers, F. & Verkade, H. J., jan-2026, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1871, 1, 19 blz., 159697.

Onderzoeksoutput › › peer review

Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice

Brunner, S., Plagge, J., Zimmermann-Kogadeeva, M., Höring, M., Liebisch, G., Basic, M., Bolsega, S., Janssen, K. P., Slack, E., von Gamm, S., Viehof-Beckmann, A., Clavel, T., Zimmermann, M., Heeren, J., Giansanti, P., Weiss, A. S., Hermeling, S., Dupont, A., Ullrich, A. L. & Jokisch, F., Seeliger, C., Bleich, A., Hidrobo, M., Stecher, B., Coleman, O. I., Moresi, C., Greter, G., Arnoldini, M., Scheiber, J., Matysik, S., Klingenspor, M., Küster, B., Haller, D., Burkhardt, R., Kuipers, F. & Ecker, J., aug-2026, In: Nature Microbiology. 11, 8, blz. 2349-2364 30 blz.

Onderzoeksoutput › › peer review

Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis

Sachdev, V., van Loon, N. M., Kingma, J., Ottenhoff, R., Tan, J. M. E., van den Berg, M., Duijst, S., Jongejan, A., Levels, J. H. M., Rensen, P. C. N., Kooijman, S., de Boer, J.-F., Kuipers, F., Kuentzel, K. B., Kratky, D., Kwon, Y., Zeigerer, A., Hendrix, S. & Zelcer, N., 1-jun-2026, In: Molecular metabolism. 108, 16 blz., 102379.

Onderzoeksoutput › › peer review

Maternal influences on infant gut microbiome and health

Lifelines NEXT cohort study, Sinha, T., Brushett, S., Fernández-Pato, A., Garmaeva, S., Andreu-Sánchez, S., Spreckels, J. E., Mallon, C. A., Kuzub, N., Gois, M. B., Wu, J., Kruk, M., Jankipersadsing, S. A., Dekens, J. A. M., Gacesa, R., Vila, A. V., Bang, C., Perenboom, C., Franke, A. & Tytgat, H. L. P., Mottaz, S. C., Peters, L., de Jonge, A., Verkade, H. J., Swertz, M. A., Wijmenga, C., Kuipers, F., Scherjon, S., Sikkema, J., Sprikkelman, A. B., de Kroon, M. L. A., Prins, J. R., Gordijn, S. J., Koppelman, G. H., Reijneveld, S. A., Fu, J., Yassour, M., Kurilshikov, A. & Zhernakova, A., okt-2026, In: Nature. 658, blz. 218-229 12 blz.

Onderzoeksoutput › › peer review

Mice with humanized FXR ligand-binding domain display distinct metabolic responses upon pharmacological FXR stimulation

Li, J., de Vries, H. D., Ustyantsev, K., Hovingh, M. V., Mulder, N. L., Havinga, R., Huijkman, N., Falcone, S., de Bruyn, K., Weersing, E., Kloosterhuis, N. J., Smit, M., Berezikov, E., van de Sluis, B., Verkade, H. J., Kuipers, F. & de Boer, J. F., aug-2026, In: Journal of Lipid Research. 67, 8, 16 blz., 101088.

Onderzoeksoutput › › peer review