prof. dr. F. (Folkert) Kuipers
Research
Research units:
Research interests
- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades
- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)
- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches
- Quantification of metabolic fluxes by stable isotope procedures
Publications
Glucose-6-phosphate regulates hepatic bile acid synthesis in mice
Hoogerland, J. A., Lei, Y., Wolters, J. C., de Boer, J. F., Bos, T., Bleeker, A., Mulder, N. L., van Dijk, T. H., Kuivenhoven, J. A., Rajas, F., Mithieux, G., Haeusler, R. A., Verkade, H. J., Bloks, V. W., Kuipers, F. & Oosterveer, M. H., 2019, In : Hepatology.Research output: Contribution to journal › Article › Academic › peer-review
A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice
de Boer, J. F., Verkade, E., Mulder, N. L., de Vries, H. D., Huijkman, N., Koehorst, M., Boer, T., Wolters, J. C., Bloks, V. W., van de Sluis, B. & Kuipers, F., Apr-2019, In : Journal of Hepatology. 70, p. E25-E26 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk: A Cross-Sectional Study
Kurilshikov, A., van den Munckhof, I. C., Chen, L., Bonder, M. J., Schraa, K., Rutten, J., Riksen, N. P., de Graaf, J., Oosting, M., Sanna, S., Joosten, L. A., van der Graaf, M., Brand, T., Koonen, D. P., van Faassen, M. J., Slagboom, P. E., Xavier, R. J., Kuipers, F., Hofker, M., Wijmenga, C., Netea, M. G., Zhernakova, A. & Fu, J., 11-Apr-2019, In : Circulation research.Research output: Contribution to journal › Article › Academic › peer-review
Targeting senescent cells alleviates obesity-induced metabolic dysfunction
Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang-Verzosa, G., Johnson, K. O., Cubro, H., Doornebal, E. J., Ogrodnik, M., Jurk, D., Jensen, M. D., Chini, E. N., Miller, J. D., Matveyenko, A., Stout, M. B., Schafer, M. J., White, T. A., Hickson, L. J., Demaria, M., Garovic, V., Grande, J., Arriaga, E. A., Kuipers, F., von Zglinicki, T., LeBrasseur, N. K., Campisi, J., Tchkonia, T. & Kirkland, J. L., 2019, In : Aging Cell. p. e12950Research output: Contribution to journal › Article › Academic › peer-review
Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High-Fat Diet
Wan, S., Kuipers, F., Havinga, R., Ando, H., Vance, D. E., Jacobs, R. L. & van der Veen, J. N., Feb-2019, In : Hepatology communications. 3, 2, p. 262-276 15 p.Research output: Contribution to journal › Article › Academic › peer-review
ID: 105673