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How to find us prof. dr. F. (Folkert) Kuipers

University Medical Center Groningen

prof. dr. F. (Folkert) Kuipers

prof. dr. F. (Folkert) Kuipers

Faculty of Medical Sciences

Telephone:

+31 50 361 6620

E-mail:

f.kuipers umcg.nl

ORCID Research Portal

Research interests

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

Publications

Altered bile acid kinetics contribute to postprandial hypoglycaemia after Roux-en-Y gastric bypass surgery

van den Broek, M. , de Heide, L. J. M., Sips, F. L. P., Koehorst, M. , van Zutphen, T. , Emous, M. , van Faassen, M. , Groen, A. K. , van Riel, N. A. W., de Boer, J. F. , van Beek, A. P. & Kuipers, F. , 15-Jan-2021 , (E-pub ahead of print) In: International Journal of Obesity.

Research output: Contribution to journal › Article › Academic › peer-review

Emerging roles of bile acids in control of intestinal functions

Yang, J. , Palmiotti, A. & Kuipers, F. , Mar-2021 , In: Current opinion in clinical nutrition and metabolic care. p. 127-133 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Gut microbiome and bile acids in obesity-related diseases

Li, R. , Andreu-Sánchez, S., Kuipers, F. & Fu, J. , 10-Feb-2021 , (E-pub ahead of print) In: Best practice & research. Clinical endocrinology & metabolism. 14 p. , 101493.

Research output: Contribution to journal › Review article › peer-review

Impaired VLDL catabolism links hypoglycemia to hypertriglyceridemia in GSD Ia

Hoogerland, J. A. , Peeks, F. , Hijmans, B. S., Wolters, J. C. , Kooijman, S., Bos, T. , Bleeker, A. , van Dijk, T. H. , Wolters, H., Gerding, A., van Eunen, K. , Havinga, R. , Pronk, A. C. M., Rensen, P. C. N., Mithieux, G., Rajas, F., Kuipers, F. , Reijngoud, D-J. , Derks, T. G. J. & Oosterveer, M. H. , 2021 , (E-pub ahead of print) In: Journal of Inherited Metabolic Disease.

Research output: Contribution to journal › Article › Academic › peer-review

24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer's Disease

Martens, N., Schepers, M., Zhan, N., Leijten, F., Voortman, G., Tiane, A., Rombaut, B., Poisquet, J., Sande, N. V. D., Kerksiek, A., Kuipers, F. , Jonker, J. W. , Liu, H., Lütjohann, D., Vanmierlo, T. & Mulder, M. T., 27-Mar-2021 , In: Marine Drugs. 19 , 4 , 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice[S]

de Boer, J. F. , Verkade, E., Mulder, N. L. , de Vries, H. D. , Huijkman, N. C. , Koehorst, M. , Boer, T. , Wolters, J. C. , Bloks, V. W. , van de Sluis, B. & Kuipers, F. , Mar-2020 , In: Journal of Lipid Research. 61 , 3 , p. 291-305 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

An early-life diet containing large phospholipid-coated lipid globules programs later-life postabsorptive lipid trafficking in high-fat diet but not in low-fat dietfed mice

Ronda, O. A. H. O. , van de Heijning, B. J. M., Martini, I. A., Koehorst, M. , Havinga, R. , Jurdzinski, A., Bloks, V. W. , van Dijk, T. H. , van der Beek, E. M. , Kuipers, F. & Verkade, H. J. , 3-Jul-2020 , (E-pub ahead of print) In: British Journal of Nutrition. p. 1-25 25 p.

Research output: Contribution to journal › Article › Academic › peer-review

Blocking sodium-taurocholate cotransporting polypeptide stimulates biliary cholesterol and phospholipid secretion

Roscam Abbing, R. L. P., Slijepcevic, D., Donkers, J. M., Havinga, R. , Duijst, S., Paulusma, C. C., Kuiper, J., Kuipers, F. , Groen, A. K. , Oude Elferink, R. P. J. & van de Graaf, S. F. J., Jan-2020 , In: Hepatology. 71 , 1 , p. 247-258 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Cholangiopathy and biliary fibrosis in Cyp2c70-deficient mice are fully reversed by ursodeoxycholic acid

de Boer, J. F. , de Vries, H. D. , Palmiotti, A. , Li, R., Doestzada, M. , Hoogerland, J. A. , Fu, J. , La Rose, A. M. , Westerterp, M. , Mulder, N. L. , Hovingh, M. V. , Koehorst, M. , Kloosterhuis, N. J. , Wolters, J. C. , Bloks, V. W. , Haas, J. T., Dombrowicz, D., Staels, B., van de Sluis, B. & Kuipers, F. , 10-Dec-2020 , (E-pub ahead of print) In: Cellular and molecular gastroenterology and hepatology.

Research output: Contribution to journal › Article › Academic › peer-review

Cholecystectomy increases the risk of dumping syndrome and postbariatric hypoglycemia after bariatric surgery

van Furth, A. M., van den Broek, M. , Emous, M. , de Heide, L. J. M., Kuipers, F. & van Beek, A. P. , Dec-2020 , In: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 16 , 12 , p. 1939-1947 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

All (395) publications

Press/media

Journal News - From the Journals

Folkert Kuipers

01/10/2019

Press/Media: Other › Academic

De rol van het microbioom bij het ontstaan van hart- en vaatziekten

Debby Koonen & Folkert Kuipers

01/05/2019

Press/Media: Research › Popular

All (2) press/media

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