prof. dr. F. (Folkert) Kuipers

prof. dr. F. (Folkert) Kuipers
E-mail:
f.kuipers umcg.nl

Research

Research interests

 

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

 

Publications
  1. Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity

    Chen, L., Collij, V., Jaeger, M., van den Munckhof, I. C. L., Vich Vila, A., Kurilshikov, A., Gacesa, R., Sinha, T., Oosting, M., Joosten, L. A. B., Rutten, J. H. W., Riksen, N. P., Xavier, R. J., Kuipers, F., Wijmenga, C., Zhernakova, A., Netea, M. G., Weersma, R. K. & Fu, J., 11-Aug-2020, In : Nature Communications. 11, 1, p. 4018 12 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice

    Gautier, T., de Haan, W., Grober, J., Ye, D., Bahr, M. J., Claudel, T., Nijstad, N., Van Berkel, T. J. C., Havekes, L. M., Manns, M. P., Willems, S. M., Hogendoorn, P. C. W., Lagrost, L., Kuipers, F., Van Eck, M., Rensen, P. C. N. & Tietge, U. J. F., Aug-2013, In : Journal of Lipid Research. 54, 8, p. 2195-2205 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Reply to Letter to the Editor HEP-20-0593

    Roscam Abbing, R. L. P., Kuipers, F., Paulusma, C. C., Verkade, H. J., Groen, A. K., Oude Elferink, R. P. J., van, S. F. J. & de Graaf, I. M., 25-Apr-2020, In : Hepatology.

    Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

  4. Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification

    Kuipers, F., de Boer, J. F. & Staels, B., 3-Mar-2020, In : Cell metabolism. 31, 3, p. 445-447 3 p.

    Research output: Contribution to journalEditorialAcademicpeer-review

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Press / Media
  1. Journal News - From the Journals

    Folkert Kuipers

    01/10/2019

    1 item of Media coverage

    Press/Media: OtherAcademic

  2. De rol van het microbioom bij het ontstaan van hart- en vaatziekten

    Debby Koonen & Folkert Kuipers

    01/05/2019

    1 item of Media coverage

    Press/Media: ResearchPopular

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Activities
  1. European Association for the Study of Diabetes (External organisation)

    Folkert Kuipers (Member)
    2019

    Activity: MembershipMembership of networkProfessional

  2. European Atherosclerosis Society (External organisation)

    Folkert Kuipers (Member)
    2019

    Activity: MembershipMembership of networkProfessional

  3. Dutch Association for Diabetes Research (NVDO) (External organisation)

    Folkert Kuipers (Member)
    2019

    Activity: MembershipMembership of networkProfessional

View all (8) »

ID: 105673