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Over ons Praktische zaken Waar vindt u ons prof. dr. F. (Folkert) Kuipers

University Medical Center Groningen

prof. dr. F. (Folkert) Kuipers

Profielfoto van prof. dr. F. (Folkert) Kuipers

Faculteit Medische Wetenschappen/UMCG

Telefoon:

E-mail:

f.kuipers umcg.nl

ORCID Research Portal

Research interests

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

Publicaties

Elevated plasma bile acids coincide with cardiac stress and inflammation in young Cyp2c70−/− mice

de Vries, H. D., Eijgenraam, T. R., Bloks, V. W., Mulder, N. L., van Zutphen, T., Silljé, H. H. W., Kuipers, F. & de Boer, J. F., 2025, In: Pediatric Research. 97, blz. 2145–2152 8 blz.

Onderzoeksoutput › › peer review

Glycodeoxycholic acid inhibits primary bile acid synthesis with minor effects on glucose- and lipid homeostasis in humans

Meessen, E. C. E., Majait, S., Ay, Ü., Olde Damink, S. W., Romijn, J. A., Holst, J. J., Hartmann, B., Kuipers, F., Nieuwdorp, M., Schaap, F. G., Groen, A. K., Kemper, E. M. & Soeters, M. R., mei-2025, In: Journal of Clinical Endocrinology and Metabolism. 110, 5, blz. 1468–1477 10 blz.

Onderzoeksoutput › › peer review

Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury

Attema, B. & Kuipers, F., mei-2025, In: EMBO Molecular Medicine. 17, 5, blz. 863-865 3 blz.

Onderzoeksoutput › › peer review

New insights in amino sugar metabolism by the gut microbiome

Shen, W., de Boer, J. F., Kuipers, F. & Fu, J., dec.-2025, In: Gut Microbes. 17, 1, 12 blz., 2510462.

Onderzoeksoutput › peer review

One probe fits all: a highly customizable modular RNA in situ hybridization platform expanding the application of SABER DNA probes

Ustyantsev, K., Stranges, M., Volpe, F. G., de Boer, J. F., Kuipers, F., Mouton, S. & Berezikov, E., jun.-2025, In: DEVELOPMENT. 152, 11, 11 blz., dev204775.

Onderzoeksoutput › › peer review

Pretreatment serum bile acid composition and predictability of subsequent response to odevixibat in patients with bile salt export pump (BSEP) deficiency

Nomden, M., Kuipers, F., Lexmond, W. S., Gu, T., Valcheva, V., Lindström, E. & Verkade, H. J., 11-jul.-2025, (E-pub ahead of print) In: Hepatology. 28 blz.

Onderzoeksoutput › › peer review

Role for the liver X receptor agonist 22-ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

Martens, N., Zhan, N., Yam, S. C., Palumbo, M., Pontini, L., Leijten, F. P. J., van Vark-van der Zee, L., Voortman, G., Friedrichs, S., Gerding, A., Marinozzi, M., Jonker, J. W., Kuipers, F., Lütjohann, D., Vanmierlo, T. & Mulder, M. T., 15-apr.-2025, (E-pub ahead of print) In: British Journal of Pharmacology. 23 blz.

Onderzoeksoutput › › peer review

SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis

Halmos, B., La Rose, A. M., Methorst, D., Groenen, A. G., Nakládal, D., Bazioti, V., Koster, M. H., Kloosterhuis, N. J., Buiten, A. V., Schouten, E. M., Huijkman, N. C. A., Langelaar-Makkinje, M., Bongiovanni, L., De Neck, S. M., de Bruin, A., Buikema, H., Deelman, L. E., van den Heuvel, M. C., Kuipers, F. & de Jong, I. J.& 4 anderen, Sluimer, J. C., Jørgensen, H. F., Henning, R. H. & Westerterp, M., 28-feb.-2025, In: Circulation Research. 136, 5, blz. 491-507 17 blz.

Onderzoeksoutput › › peer review

The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice

Yntema, T., Eijgenraam, T. R., Kloosterhuis, N. J., Havinga, R., Koster, M. H., Hovingh, M. V., de Boer, J. F., Koonen, D. P. Y. & Kuipers, F., 15-jan.-2025, In: Scientific Reports. 15, 1, 11 blz., 2100.

Onderzoeksoutput › › peer review

Therapeutic hyperthermia promotes lipid export and HSP70/90 during machine perfusion of human livers

Thorne, A. M., Geng, Y., Lantinga, V. A., Smit, M., Kuivenhoven, J. A., Porte, R. J., Kuipers, F., Olinga, P., Wolters, J. C. & de Meijer, V. E., mei-2025, In: Physiological Reports. 13, 9, 18 blz., e70348.

Onderzoeksoutput › › peer review

Alle (489) publicaties

Pers/media

Verouderingsproces tegenhouden

Kuipers, F.

21/08/2024 → 23/08/2024

Pers / media: Expert Comment ›

Verouderingsonderzoek Eriba bestaat 10 jaar: ‘Zoeken naar medicijnen om gezond te blijven’

Kuipers, F.

14/12/2023

Pers / media: Expert Comment ›

Journal News - From the Journals

Kuipers, F.

01/10/2019

Pers / media: Overig ›

De rol van het microbioom bij het ontstaan van hart- en vaatziekten

Koonen, D. & Kuipers, F.

01/05/2019

Pers / media: Onderzoek ›

Alle (4) pers/media

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