prof. dr. F. (Folkert) Kuipers
Research
Research units:
Research interests
- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades
- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)
- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches
- Quantification of metabolic fluxes by stable isotope procedures
Publications
Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidemia and atherosclerosis development
Zhou, E., Hoeke, G., Li, Z., Eibergen, A. C., Schonk, A. W., Koehorst, M., Boverhof, R., Havinga, R., Kuipers, F., Coskun, T., Boon, M. R., Groen, A. K., Rensen, P. C. N., Berbée, J. F. P. & Wang, Y., 2019, In : Cardiovascular Research. 11 p.Research output: Contribution to journal › Article › Academic › peer-review
A Human-like Bile Acid Pool Induced by Deletion of Cyp2c70 Modulates Effects of Farnesoid X Receptor Activation in Mice
de Boer, J. F., Verkade, E., Mulder, N. L., de Vries, H. D., Huijkman, N. C., Koehorst, M., Boer, T., Wolters, J. C., Bloks, V. W., van de Sluis, B. & Kuipers, F., 10-Sep-2019, In : Journal of Lipid Research.Research output: Contribution to journal › Article › Academic › peer-review
WHAT IS THE ORIGIN OF SEVERE HYPERCHOLESTEROLEMIA IN A LARGE COHORT OF EMIRATIS WITH A HIGH PREVALANCE OF TYPE 2 DIABETES
Rimbert, A., Kuivenhoven, J. A., Lansberg, P., Viel, M., Kanninga, R., Johansson, L., Kuipers, F., Bloks, V., van Faassen, M., Koehorst, M., Sinke, R., Daggag, H., Al Tikriti, A. & Barakat, M. T., Aug-2019, In : ATHEROSCLEROSIS. 287, p. E198-E199 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
GENDER-SPECIFIC DIFFERENCES AT BOTH EXTREME ENDS OF THE LDL CHOLESTEROL DISTRIBUTION CURVE
Rimbert, A., Balder, J. W., Zhang, X., Wolters, K., Lansberg, P., Viel, M., Kanninga, R., Johansson, L., Bloks, V., van Daasen, M., Koehorst, M., Kuipers, F., Sinke, R., Groen, A., Dallinga-Thie, G. & Kuivenhoven, J. A., Aug-2019, In : ATHEROSCLEROSIS. 287, p. E64 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
A HUMAN-LIKE COMPOSITION OF THE CIRCULATING BILE ACID POOL IMPACTS ON PLASMA LDL CHOLESTEROL IN MICE
De Boer, J. F., de Vries, H. D., Palmiotti, A., Li, R., Mulder, N. L., Hovingh, M. V., Koehorst, M., Kloosterhuis, N. J., Bloks, V. W., van de Sluis, B. & Kuipers, F., Aug-2019, In : ATHEROSCLEROSIS. 287, p. E14-E14 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
ID: 105673