prof. dr. F. (Folkert) Kuipers
Research
Research units:
Research interests
- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades
- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)
- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches
- Quantification of metabolic fluxes by stable isotope procedures
Publications
Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice
Gautier, T., de Haan, W., Grober, J., Ye, D., Bahr, M. J., Claudel, T., Nijstad, N., Van Berkel, T. J. C., Havekes, L. M., Manns, M. P., Willems, S. M., Hogendoorn, P. C. W., Lagrost, L., Kuipers, F., Van Eck, M., Rensen, P. C. N. & Tietge, U. J. F., Aug-2013, In : Journal of Lipid Research. 54, 8, p. 2195-2205 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Reply to Letter to the Editor HEP-20-0593
Roscam Abbing, R. L. P., Kuipers, F., Paulusma, C. C., Verkade, H. J., Groen, A. K., Oude Elferink, R. P. J., van, S. F. J. & de Graaf, I. M., 25-Apr-2020, In : Hepatology.Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification
Kuipers, F., de Boer, J. F. & Staels, B., 3-Mar-2020, In : Cell metabolism. 31, 3, p. 445-447 3 p.Research output: Contribution to journal › Editorial › Academic › peer-review
Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study
Warmink-Perdijk, W. D. B., Peters, L. L., Tigchelaar, E. F., Dekens, J. A. M., Jankipersadsing, S. A., Zhernakova, A., Bossers, W. J. R., Sikkema, J., de Jonge, A., Reijneveld, S. A., Verkade, H. J., Koppelman, G. H., Wijmenga, C., Kuipers, F. & Scherjon, S. A., 25-Feb-2020, In : European Journal of Epidemiology. 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidemia and atherosclerosis development
Zhou, E., Hoeke, G., Li, Z., Eibergen, A. C., Schonk, A. W., Koehorst, M., Boverhof, R., Havinga, R., Kuipers, F., Coskun, T., Boon, M. R., Groen, A. K., Rensen, P. C. N., Berbée, J. F. P. & Wang, Y., 7-Oct-2019, In : Cardiovascular Research. 11 p., cvz253.Research output: Contribution to journal › Article › Academic › peer-review
Press / Media
De rol van het microbioom bij het ontstaan van hart- en vaatziekten
Debby Koonen & Folkert Kuipers
01/05/2019
1 item of Media coverage
Press/Media: Research › Popular
Activities
European Association for the Study of Diabetes (External organisation)
Folkert Kuipers (Member)2019Activity: Membership › Membership of network › Professional
European Atherosclerosis Society (External organisation)
Folkert Kuipers (Member)2019Activity: Membership › Membership of network › Professional
Dutch Association for Diabetes Research (NVDO) (External organisation)
Folkert Kuipers (Member)2019Activity: Membership › Membership of network › Professional
ID: 105673