prof. dr. F. (Folkert) Kuipers

Faculty of Medical Sciences

Telephone:

+31 50 361 6620

E-mail:

f.kuipers umcg.nl

ORCID Research Portal

Research interests

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

Publications

Ablation of liver Fxr results in an increased colonic mucus barrier in mice

Ijssennagger, N. , van Rooijen, K. S. , Magnúsdóttir, S. , Ramos Pittol, J. M. , Willemsen, E. C. L. , de Zoete, M. R. , Baars, M. J. D. , Stege, P. B. , Colliva, C. , Pellicciari, R. , Youssef, S. A. , de Bruin, A. , Vercoulen, Y. , Kuipers, F. & van Mil, S. W. C. , Oct-2021 , In: JHEP reports : innovation in hepatology. 3 , 5 , p. 100344 10 p. , 100344.

Research output: Contribution to journal › Article › Academic › peer-review

Altered bile acid kinetics contribute to postprandial hypoglycaemia after Roux-en-Y gastric bypass surgery

van den Broek, M. , de Heide, L. J. M. , Sips, F. L. P. , Koehorst, M. , van Zutphen, T. , Emous, M. , van Faassen, M. , Groen, A. K. , van Riel, N. A. W. , de Boer, J. F. , van Beek, A. P. & Kuipers, F. , Mar-2021 , In: International Journal of Obesity. 45 , 3 , p. 619-630 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

An early-life diet containing large phospholipid-coated lipid globules programs later-life postabsorptive lipid trafficking in high-fat diet but not in low-fat dietfed mice

Ronda, O. A. H. O. , van de Heijning, B. J. M. , Martini, I. A. , Koehorst, M. , Havinga, R. , Jurdzinski, A. , Bloks, V. W. , van Dijk, T. H. , van der Beek, E. M. , Kuipers, F. & Verkade, H. J. , 14-May-2021 , In: British Journal of Nutrition. 125 , 9 , p. 961-971 11 p. , 0007114520002421.

Research output: Contribution to journal › Article › Academic › peer-review

Cholangiopathy and biliary fibrosis in Cyp2c70-deficient mice are fully reversed by ursodeoxycholic acid

de Boer, J. F. , de Vries, H. D. , Palmiotti, A. , Li, R. , Doestzada, M. , Hoogerland, J. A. , Fu, J. , La Rose, A. M. , Westerterp, M. , Mulder, N. L. , Hovingh, M. V. , Koehorst, M. , Kloosterhuis, N. J. , Wolters, J. C. , Bloks, V. W. , Haas, J. T. , Dombrowicz, D. , Staels, B. , van de Sluis, B. & Kuipers, F. , 2021 , In: Cellular and molecular gastroenterology and hepatology. 11 , 4 , p. 1045-1069 25 p.

Research output: Contribution to journal › Article › Academic › peer-review

Dynamic binning peak detection and assessment of various lipidomics liquid chromatography-mass spectrometry pre-processing platforms

Feng, X. , Zhang, W. , Kuipers, F. , Kema, I. , Barcaru, A. & Horvatovich, P. , 15-Aug-2021 , In: Analytica Chimica Acta. 1173 , 13 p. , 338674.

Research output: Contribution to journal › Article › Academic › peer-review

Emerging roles of bile acids in control of intestinal functions

Yang, J. , Palmiotti, A. & Kuipers, F. , Mar-2021 , In: Current opinion in clinical nutrition and metabolic care. 24 , 2 , p. 127-133 7 p.

Research output: Contribution to journal › Review article › Academic › peer-review

Gut microbiome and bile acids in obesity-related diseases

Li, R. , Andreu-Sánchez, S. , Kuipers, F. & Fu, J. , May-2021 , In: Best practice & research. Clinical endocrinology & metabolism. 35 , 3 , 14 p. , 101493.

Research output: Contribution to journal › Review article › Academic › peer-review

Gut-microbe derived TMAO and its association with more progressed forms of AF: Results from the AF-RISK study

Nguyen, B. O. , Meems, L. M. G. , van Faassen, M. , Crijns, H. J. G. M. , van Gelder, I. C. , Kuipers, F. & Rienstra, M. , Jun-2021 , In: International journal of cardiology. Heart & vasculature. 34 , p. 1-3 3 p. , 100798.

Research output: Contribution to journal › Article › Academic › peer-review

Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia

La Rose, A. M. , Bazioti, V. , Hoogerland, J. A. , Svendsen, A. F. , Groenen, A. G. , van Faassen, M. , Rutten, M. G. S. , Kloosterhuis, N. J. , Dethmers-Ausema, B. , Nijland, J. H. , Mithieux, G. , Rajas, F. , Kuipers, F. , Lukens, M. V. , Soehnlein, O. , Oosterveer, M. H. & Westerterp, M. , Nov-2021 , In: Molecular metabolism. 53 , p. 1-14 14 p. , 101265.

Research output: Contribution to journal › Article › Academic › peer-review

Impaired Bile Acid Metabolism and Gut Dysbiosis in Mice Lacking Lysosomal Acid Lipase

Sachdev, V. , Duta-Mare, M. , Korbelius, M. , Vujić, N. , Leopold, C. , Freark de Boer, J. , Rainer, S. , Fickert, P. , Kolb, D. , Kuipers, F. , Radovic, B. , Gorkiewicz, G. & Kratky, D. , 1-Oct-2021 , In: Cells. 10 , 10 , 18 p. , 2619.

Research output: Contribution to journal › Article › Academic › peer-review

All (414) publications

Press/media

Journal News - From the Journals

Folkert Kuipers

01/10/2019

Press/Media: Other › Academic

De rol van het microbioom bij het ontstaan van hart- en vaatziekten

Debby Koonen & Folkert Kuipers

01/05/2019

Press/Media: Research › Popular

All (2) press/media

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