prof. dr. F. (Folkert) Kuipers

Research

Research interests

 

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

 

Publications
  1. Farnesoid X Receptor alters adipose tissue architecture in mice and limits storage capacity leading to metabolic derangements

    van Zutphen, T., Stroeve, J. H. M., Yang, J., Bloks, V. W., Jurdzinski, A., Roelofsen, H., Huijkman, N. C. A., van Dijk, T. H., Vonk, R. J., van Deursen, J., Staels, B., Groen, A. K. & Kuipers, F., 28-Jun-2019, In : Journal of Lipid Research.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Relationship between liver size and liver function in mice

    Ronda, O., Havinga, H., van de Heijning, B. J. M., Kuipers, F. & Verkade, H., 15-May-2019, In : Journal of Pediatric Gastroenterology and Nutrition. 68, p. 750

    Research output: Contribution to journalMeeting AbstractAcademic

  3. The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance

    Wijers, M., Zanoni, P., Liv, N., Vos, D. Y., Jackstein, M. Y., Smit, M., Wilbrink, S., Wolters, J. C., van der Veen, Y. T., Huijkman, N., Dekker, D., Kloosterhuis, N., van Dijk, T. H., Billadeau, D. D., Kuipers, F., Klumperman, J., von Eckardstein, A., Kuivenhoven, J. A. & van de Sluis, B., 6-Jun-2019, In : JCI Insight. 4, 11, 16 p., 126462.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Blocking sodium-taurocholate cotransporting polypeptide stimulates biliary cholesterol and phospholipid secretion

    Roscam Abbing, R. L. P., Slijepcevic, D., Donkers, J. M., Havinga, R., Duijst, S., Paulusma, C. C., Kuiper, J., Kuipers, F., Groen, A. K., Oude Elferink, R. P. J. & van de Graaf, S. F. J., 2019, In : Hepatology. 27 p.

    Research output: Contribution to journalArticleAcademicpeer-review

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