prof. dr. F. (Folkert) Kuipers

Telephone:

E-mail:

f.kuipers umcg.nl

Research interests

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

Publications

Back to basics: Bile acids in fat absorption

Kuipers, F., Verkade, H. J. & Freark de Boer, J., 3-Feb-2026, In: Cell Metabolism. 38, 2, p. 249-251 3 p.

Research output: Contribution to journal › Article › Academic › peer-review

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70-Deficient Mice With a Human-Like Bile Acid Composition

de Vries, H. D., Li, J., Ustyantsev, K., Hovingh, M. V., Mulder, N. L., Havinga, R., Palmiotti, A., de Bruyn, K., Attema, B., Weersing, E., Thomas, R. E., Bloks, V. W., Berezikov, E., van Faassen, M., Verkade, H. J., de Boer, J. F. & Kuipers, F., May-2026, In: Liver International. 46, 5, p. e70632

Research output: Contribution to journal › Article › Academic › peer-review

Generation and characterization of a mouse model for bile salt export pump deficiency with the p.E297G mutation

Felzen, A., Hof, W. F. J., de Vries, H., Hovingh, M. V., Havinga, R., Mulder, N. L., Koehorst, M., Kloosterhuis, N., Smit, M., Huijkman, N., van de Sluis, B., de Boer, J. F., Kuipers, F. & Verkade, H. J., Jan-2026, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1871, 1, 19 p., 159697.

Research output: Contribution to journal › Article › Academic › peer-review

Condensate-Driven Triglyceride Depletion Links α-Synuclein to Mitochondrial Dysfunction

Zhang, T., Goya, M. E., Herron-Bedoya, A., van der Weerd, J. C., Tsagkari, D., Couzijn, S., Güngördü, L., Seinstra, R. I., Heiner Fokkema, M. R., Chang, M., Tavernarakis, N., Kuipers, F. & Nollen, E. A. A., 18-Nov-2025, BioRxiv, 35 p. (bioRxiv).

Research output: Working paper › Preprint › Academic

Divergent regulation of cellular cholesterol metabolism by seaweed-derived fucosterol and saringosterol

Zhan, N., Martens, N., Li, Y., Voortman, G., Leijten, F., Friedrichs, S., Caspers, M. P. M., Verschuren, L., Vanmierlo, T., Smit, M., Kuipers, F., Jonker, J. W., Bloks, V. W., Palumbo, M., Zimetti, F., Adorni, M. P., Liu, H., Lütjohann, D. & Mulder, M. T., 2-Dec-2025, In: Frontiers in Marine Science. 12, 18 p., 1728727.

Research output: Contribution to journal › Article › Academic › peer-review

Elevated plasma bile acids coincide with cardiac stress and inflammation in young Cyp2c70−/− mice

de Vries, H. D., Eijgenraam, T. R., Bloks, V. W., Mulder, N. L., van Zutphen, T., Silljé, H. H. W., Kuipers, F. & de Boer, J. F., 2025, In: Pediatric Research. 97, p. 2145–2152 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Glycodeoxycholic acid inhibits primary bile acid synthesis with minor effects on glucose- and lipid homeostasis in humans

Meessen, E. C. E., Majait, S., Ay, Ü., Olde Damink, S. W., Romijn, J. A., Holst, J. J., Hartmann, B., Kuipers, F., Nieuwdorp, M., Schaap, F. G., Groen, A. K., Kemper, E. M. & Soeters, M. R., May-2025, In: Journal of Clinical Endocrinology and Metabolism. 110, 5, p. 1468–1477 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury

Attema, B. & Kuipers, F., May-2025, In: EMBO Molecular Medicine. 17, 5, p. 863-865 3 p.

Research output: Contribution to journal › Letter (Research letter) › Academic › peer-review

New insights in amino sugar metabolism by the gut microbiome

Shen, W., de Boer, J. F., Kuipers, F. & Fu, J., Dec-2025, In: Gut Microbes. 17, 1, 12 p., 2510462.

Research output: Contribution to journal › Review article › peer-review

One probe fits all: a highly customizable modular RNA in situ hybridization platform expanding the application of SABER DNA probes

Ustyantsev, K., Stranges, M., Volpe, F. G., de Boer, J. F., Kuipers, F., Mouton, S. & Berezikov, E., Jun-2025, In: DEVELOPMENT. 152, 11, 11 p., dev204775.

Research output: Contribution to journal › Article › Academic › peer-review