prof. dr. F. (Folkert) Kuipers

prof. dr. F. (Folkert) Kuipers
E-mail:
f.kuipers umcg.nl

Research

Research interests

 

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

 

Publications
  1. Emerging roles of bile acids in control of intestinal functions

    Yang, J., Palmiotti, A. & Kuipers, F., 2020, In : Current opinion in clinical nutrition and metabolic care. 7 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

    Chen, L., Schraa, K., van den Munckhof, I. C. L., Ter Horst, R., Koehorst, M., van Faassen, M., van der Ley, C., Doestzada, M., Zhernakova, D. V., Kurilshikov, A., Bloks, V. W., Groen, A. K., Human Functional Genomics Project, Riksen, N. P., Rutten, J. H. W., Joosten, L. A. B., Wijmenga, C., Zhernakova, A., Netea, M. G., Fu, J. & Kuipers, F., 6-Oct-2020, In : Cell reports. 33, 1, 13 p., 108212.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Effects of an early life diet containing large phospholipid-coated lipid globules on hepatic lipid metabolism in mice

    Ronda, O. A. H. O., van de Heijning, B. J. M., Martini, I., Gerding, A., Wolters, J. C., van der Veen, Y. T., Koehorst, M., Jurdzinski, A., Havinga, R., van der Beek, E. M., Kuipers, F. & Verkade, H. J., 30-Sep-2020, In : Scientific Reports. 10, 1, 14 p., 16128.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet

    Ronda, O. A. H. O., van de Heijning, B. J. M., de Bruin, A., Thomas, R. E., Martini, I., Koehorst, M., Gerding, A., Koster, M. H., Bloks, V. W., Jurdzinski, A., Mulder, N. L., Havinga, R., van der Beek, E. M., Reijngoud, D-J., Kuipers, F. & Verkade, H. J., 21-Sep-2020, In : PLoS ONE. 15, 9, p. e0232069 25 p., 0232069.

    Research output: Contribution to journalArticleAcademicpeer-review

View all (388) »

Press / Media
  1. Journal News - From the Journals

    Folkert Kuipers

    01/10/2019

    1 item of Media coverage

    Press/Media: OtherAcademic

  2. De rol van het microbioom bij het ontstaan van hart- en vaatziekten

    Debby Koonen & Folkert Kuipers

    01/05/2019

    1 item of Media coverage

    Press/Media: ResearchPopular

View all (2) »

Activities
  1. European Association for the Study of Diabetes (External organisation)

    Folkert Kuipers (Member)

    2019

    Activity: MembershipMembership of networkProfessional

  2. European Atherosclerosis Society (External organisation)

    Folkert Kuipers (Member)

    2019

    Activity: MembershipMembership of networkProfessional

  3. Dutch Association for Diabetes Research (NVDO) (External organisation)

    Folkert Kuipers (Member)

    2019

    Activity: MembershipMembership of networkProfessional

View all (8) »

ID: 105673