prof. dr. F. (Folkert) Kuipers
Research
Research units:
Research interests
- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades
- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)
- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches
- Quantification of metabolic fluxes by stable isotope procedures
Publications
Emerging roles of bile acids in control of intestinal functions
Yang, J., Palmiotti, A. & Kuipers, F., 2020, In : Current opinion in clinical nutrition and metabolic care. 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content
Chen, L., Schraa, K., van den Munckhof, I. C. L., Ter Horst, R., Koehorst, M., van Faassen, M., van der Ley, C., Doestzada, M., Zhernakova, D. V., Kurilshikov, A., Bloks, V. W., Groen, A. K., Human Functional Genomics Project, Riksen, N. P., Rutten, J. H. W., Joosten, L. A. B., Wijmenga, C., Zhernakova, A., Netea, M. G., Fu, J. & Kuipers, F., 6-Oct-2020, In : Cell reports. 33, 1, 13 p., 108212.Research output: Contribution to journal › Article › Academic › peer-review
Effects of an early life diet containing large phospholipid-coated lipid globules on hepatic lipid metabolism in mice
Ronda, O. A. H. O., van de Heijning, B. J. M., Martini, I., Gerding, A., Wolters, J. C., van der Veen, Y. T., Koehorst, M., Jurdzinski, A., Havinga, R., van der Beek, E. M., Kuipers, F. & Verkade, H. J., 30-Sep-2020, In : Scientific Reports. 10, 1, 14 p., 16128.Research output: Contribution to journal › Article › Academic › peer-review
Cholecystectomy increases the risk of dumping syndrome and postbariatric hypoglycemia after bariatric surgery
van Furth, A. M., van den Broek, M., Emous, M., de Heide, L. J. M., Kuipers, F. & van Beek, A. P., 25-Aug-2020, In : Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.Research output: Contribution to journal › Article › Academic › peer-review
Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet
Ronda, O. A. H. O., van de Heijning, B. J. M., de Bruin, A., Thomas, R. E., Martini, I., Koehorst, M., Gerding, A., Koster, M. H., Bloks, V. W., Jurdzinski, A., Mulder, N. L., Havinga, R., van der Beek, E. M., Reijngoud, D-J., Kuipers, F. & Verkade, H. J., 21-Sep-2020, In : PLoS ONE. 15, 9, p. e0232069 25 p., 0232069.Research output: Contribution to journal › Article › Academic › peer-review
Press / Media
De rol van het microbioom bij het ontstaan van hart- en vaatziekten
Debby Koonen & Folkert Kuipers
01/05/2019
1 item of Media coverage
Press/Media: Research › Popular
Activities
European Association for the Study of Diabetes (External organisation)
Folkert Kuipers (Member)
2019Activity: Membership › Membership of network › Professional
European Atherosclerosis Society (External organisation)
Folkert Kuipers (Member)
2019Activity: Membership › Membership of network › Professional
Dutch Association for Diabetes Research (NVDO) (External organisation)
Folkert Kuipers (Member)
2019Activity: Membership › Membership of network › Professional
ID: 105673