prof. dr. F. (Folkert) Kuipers

Telefoon:

E-mail:

f.kuipers umcg.nl

Research interests

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

Publicaties

Back to basics: Bile acids in fat absorption

Kuipers, F., Verkade, H. J. & Freark de Boer, J., 3-feb.-2026, In: Cell Metabolism. 38, 2, blz. 249-251 3 blz.

Onderzoeksoutput › › peer review

Bile acid detergency as determinant of liver pathology in a humanized mouse model of progressive familial intrahepatic cholestasis type 3

Ke, L., Mulder, N. L., Hovingh, M. V., Havinga, R., Weersing, E., de Vries, H. D., de Bruyn, K., Ustyantsev, K., Berezikov, E., Bloks, V. W., Attema, B., Worthmann, A., Heeren, J., Wolters, J. C., Tiessen-Thomas, R., Verkade, H. J., Kuipers, F. & Freark de Boer, J., 8-apr.-2026, (E-pub ahead of print) In: Cellular and molecular gastroenterology and hepatology. blz. 101783

Onderzoeksoutput › › peer review

Bile Acids and Healthy Ageing

Attema, B. & Kuipers, F., 2026, (Accepted/In press) In: Engineering. 11 blz.

Onderzoeksoutput › peer review

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70-Deficient Mice With a Human-Like Bile Acid Composition

de Vries, H. D., Li, J., Ustyantsev, K., Hovingh, M. V., Mulder, N. L., Havinga, R., Palmiotti, A., de Bruyn, K., Attema, B., Weersing, E., Thomas, R. E., Bloks, V. W., Berezikov, E., van Faassen, M., Verkade, H. J., de Boer, J. F. & Kuipers, F., mei-2026, In: Liver International. 46, 5, blz. e70632

Onderzoeksoutput › › peer review

Generation and characterization of a mouse model for bile salt export pump deficiency with the p.E297G mutation

Felzen, A., Hof, W. F. J., de Vries, H., Hovingh, M. V., Havinga, R., Mulder, N. L., Koehorst, M., Kloosterhuis, N., Smit, M., Huijkman, N., van de Sluis, B., de Boer, J. F., Kuipers, F. & Verkade, H. J., jan.-2026, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1871, 1, 19 blz., 159697.

Onderzoeksoutput › › peer review

The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism

Evangelakos, I., Verkade, E., Rohde, J. K., Zaufel, A., Vargek, M., Heine, M., Worthmann, A., Graute, S., Manka Fuh, M., Gunasekaran, K., Kumari, M., Schwinge, D., von Bergen, M., Rolle-Kampczyk, U., Engelmann, B., Breinbauer, R., Fuerst, R., Saleem, U., de Boer, J. F.& Schlein, C., Hansen, A., Scheja, L., Kuipers, F., Moustafa, T. & Heeren, J., 2-apr.-2026, (E-pub ahead of print) In: Molecular metabolism. blz. 102363

Onderzoeksoutput › › peer review

Condensate-Driven Triglyceride Depletion Links α-Synuclein to Mitochondrial Dysfunction

Zhang, T., Goya, M. E., Herron-Bedoya, A., van der Weerd, J. C., Tsagkari, D., Couzijn, S., Güngördü, L., Seinstra, R. I., Heiner Fokkema, M. R., Chang, M., Tavernarakis, N., Kuipers, F. & Nollen, E. A. A., 18-nov.-2025, BioRxiv, 35 blz. (bioRxiv).

Onderzoeksoutput: Voordruk ›

Divergent regulation of cellular cholesterol metabolism by seaweed-derived fucosterol and saringosterol

Zhan, N., Martens, N., Li, Y., Voortman, G., Leijten, F., Friedrichs, S., Caspers, M. P. M., Verschuren, L., Vanmierlo, T., Smit, M., Kuipers, F., Jonker, J. W., Bloks, V. W., Palumbo, M., Zimetti, F., Adorni, M. P., Liu, H., Lütjohann, D. & Mulder, M. T., 2-dec.-2025, In: Frontiers in Marine Science. 12, 18 blz., 1728727.

Onderzoeksoutput › › peer review

Elevated plasma bile acids coincide with cardiac stress and inflammation in young Cyp2c70−/− mice

de Vries, H. D., Eijgenraam, T. R., Bloks, V. W., Mulder, N. L., van Zutphen, T., Silljé, H. H. W., Kuipers, F. & de Boer, J. F., 2025, In: Pediatric Research. 97, blz. 2145–2152 8 blz.

Onderzoeksoutput › › peer review

Glycodeoxycholic acid inhibits primary bile acid synthesis with minor effects on glucose- and lipid homeostasis in humans

Meessen, E. C. E., Majait, S., Ay, Ü., Olde Damink, S. W., Romijn, J. A., Holst, J. J., Hartmann, B., Kuipers, F., Nieuwdorp, M., Schaap, F. G., Groen, A. K., Kemper, E. M. & Soeters, M. R., mei-2025, In: Journal of Clinical Endocrinology and Metabolism. 110, 5, blz. 1468–1477 10 blz.

Onderzoeksoutput › › peer review