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Research interests

I am a molecular cell biologist with extensive training in evolutionary bioinformatics and a keen interest in multi-disciplinary team-driven science. My main research interests are the evolutionary origin and mechanisms of chromosome segregation systems in (microbial) eukaryotes. I am particularly focused on kinetochores, small cellular structures that connect the chromosomal DNA to thread-like microtubules emanating from the spindle apparatus during cell division. Using a combination of comparative genomics, high resolution imaging and biochemistry, I aim to elucidate the inner workings and evolutionary history of this crucial part of the cell division machinery in a wide variety of eukaryotic creatures. With the tools and models that I will develop I hope to contribute towards the establishment of cell biology as a comparative and evolutionary discipline, driving not only the functional understanding of eukaryotes in a broader phylogenetic context, but also to uncover the principles of cellular evolution itself.

Publications

A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona

Chromatin binding by HORMAD proteins regulates meiotic recombination initiation

Kinetoplastid kinetochore proteins KKT14-KKT15 are divergent Bub1/BubR1-Bub3 proteins

Life-cycle-coupled evolution of mitosis in close relatives of animals

A molecular cell biology toolkit for the study of meiosis in the silkworm Bombyx mori

FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics

Increased sampling and intra-complex homologies favor vertical over horizontal inheritance of the Dam1 complex

Mapping diversity in African trypanosomes using high resolution spatial proteomics

Meiosis in Plasmodium: How does it work?

Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages

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Press/media

A Billion-Year Evolutionary Tale – Biologists Trace Cell Division Back to Its Roots

Exploring diversity in cell division: Study investigates the process of evolution that supports diverse life cycles

Study investigates the process of evolution that supports diverse life cycles

Explorando la diversidad en la división celular

Exploring Diversity In Cell Division

How Cell Division Modes Reflect Life Cycle Diversity

Mysterieuze eencellige mist belangrijke genen om DNA te kopiëren, te verdelen

Mysterious organism lacks genes that are vital to copying and distributing its DNA

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