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How to find us dr. E.C. (Eelco) Tromer

Research interests

I am a molecular cell biologist with extensive training in evolutionary bioinformatics and a keen interest in multi-disciplinary team-driven science. My main research interests are the evolutionary origin and mechanisms of chromosome segregation systems in (microbial) eukaryotes. I am particularly focused on kinetochores, small cellular structures that connect the chromosomal DNA to thread-like microtubules emanating from the spindle apparatus during cell division. Using a combination of comparative genomics, high resolution imaging and biochemistry, I aim to elucidate the inner workings and evolutionary history of this crucial part of the cell division machinery in a wide variety of eukaryotic creatures. With the tools and models that I will develop I hope to contribute towards the establishment of cell biology as a comparative and evolutionary discipline, driving not only the functional understanding of eukaryotes in a broader phylogenetic context, but also to uncover the principles of cellular evolution itself.

Publications

Molecular convergence by differential domain acquisition is a hallmark of chromosomal passenger complex evolution

A free-living protist that lacks canonical eukaryotic DNA replication and segregation systems

Chromosomal instability by mutations in the novel minor spliceosome component CENATAC

Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist

Molecular characterization of the conoid complex in Toxoplasma reveals its conservation in all apicomplexans, including Plasmodium species

Real-time dynamics of Plasmodium NDC80 reveals unusual modes of chromosome segregation during parasite proliferation

Repurposing of Synaptonemal Complex Proteins for Kinetochores in Kinetoplastida

A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions

A subcellular atlas of Toxoplasma reveals the functional context of the proteome

Conservation of the Toxoplasma conoid complex proteome reveals a cryptic conoid in Plasmodium that differentiates between blood- and vector-stage zoites

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Press/media

Mysterieuze eencellige mist belangrijke genen om DNA te kopiëren, te verdelen

Mysterious organism lacks genes that are vital to copying and distributing its DNA