dr. D.C.J. Spierings

Research

Research interests

Single cell sequencing, genome instability, structural variations, ageing, stem cells, cancer, immunology

Publications
  1. Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

    Bolhaqueiro, A. C. F., Ponsioen, B., Bakker, B., Klaasen, S. J., Kucukkose, E., van Jaarsveld, R. H., Vivié, J., Verlaan-Klink, I., Hami, N., Spierings, D. C. J., Sasaki, N., Dutta, D., Boj, S. F., Vries, R. G. J., Lansdorp, P. M., van de Wetering, M., van Oudenaarden, A., Clevers, H., Kranenburg, O., Foijer, F., Snippert, H. J. G. & Kops, G. J. P. L., May-2019, In : Nature Genetics. 51, 5, p. 824-834 16 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Multi-platform discovery of haplotype-resolved structural variation in human genomes

    Chaisson, M. J. P., Sanders, A. D., Zhao, X., Malhotra, A., Porubsky, D., Rausch, T., Gardner, E. J., Rodriguez, O. L., Guo, L., Collins, R. L., Fan, X., Wen, J., Handsaker, R. E., Fairley, S., Kronenberg, Z. N., Kong, X., Hormozdiari, F., Lee, D., Wenger, A. M., Hastie, A. R., Antaki, D., Anantharaman, T., Audano, P. A., Brand, H., Cantsilieris, S., Cao, H., Cerveira, E., Chen, C., Chen, X., Chin, C-S., Chong, Z., Chuang, N. T., Lambert, C. C., Church, D. M., Clarke, L., Farrell, A., Flores, J., Galeev, T., Gorkin, D. U., Gujral, M., Guryev, V., Heaton, W. H., Korlach, J., Kumar, S., Kwon, J. Y., Lam, E. T., Lee, J. E., Lee, J., Lee, W-P., Lee, S. P., Li, S., Marks, P., Viaud-Martinez, K., Meiers, S., Munson, K. M., Navarro, F. C. P., Nelson, B. J., Nodzak, C., Noor, A., Kyriazopoulou-Panagiotopoulou, S., Pang, A. W. C., Qiu, Y., Rosanio, G., Ryan, M., Stütz, A., Spierings, D. C. J., Ward, A., Welch, A. E., Xiao, M., Xu, W., Zhang, C., Zhu, Q., Zheng-Bradley, X., Lowy, E., Yakneen, S., McCarroll, S., Jun, G., Ding, L., Koh, C. L., Ren, B., Flicek, P., Chen, K., Gerstein, M. B., Kwok, P-Y., Lansdorp, P. M., Marth, G. T., Sebat, J., Shi, X., Bashir, A., Ye, K., Devine, S. E., Talkowski, M. E., Mills, R. E., Marschall, T., Korbel, J. O., Eichler, E. E. & Lee, C., 16-Apr-2019, In : Nature Communications. 10, 1, 16 p., 1784.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

    Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., Nelson, G., Bronk, S., Velasco, R. F., van Deursen, E-J., O'Brien, D. R., Kocher, J-P. A., Youssef, S. A., van Ree, J. H., de Bruin, A., van den Bos, H., Spierings, D. C. J., Foijer, F., van de Sluis, B., Roberts, L. R., Gores, G., Li, H. & van Deursen, J. M., 2019, In : Gastroenterology. 29 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

    Pillay, N., Tighe, A., Nelson, L., Littler, S., Coulson-Gilmer, C., Bah, N., Golder, A., Bakker, B., Spierings, D. C. J., James, D. I., Smith, K. M., Jordan, A. M., Morgan, R. D., Ogilvie, D. J., Foijer, F., Jackson, D. A. & Taylor, S. S., 18-Mar-2019, In : Cancer cell. 35, 3, p. 519-533.e8 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  5. Quantification of Aneuploidy in Mammalian Systems

    van den Bos, H., Bakker, B., Taudt, A., Guryev, V., Colomé-Tatché, M., Lansdorp, P. M., Foijer, F. & Spierings, D. C. J., 25-Nov-2018, In : Methods in Molecular Biology. 1896, p. 159-190 32 p.

    Research output: Contribution to journalArticleAcademicpeer-review

View all (36) »

Datasets
  1. Data: Direct chromosome-length haplotyping by single-cell sequencing

    Lansdorp, P. (Creator), Sanders, A. D. (Creator), van Wietmarschen, N. (Creator), Falconer, E. (Creator), Hills, M. (Creator), Spierings, D. (Creator), Bevova, M. (Creator), Guryev, V. (Creator), University of Groningen, 26-Nov-2016

    Dataset

View all (1) »

Activities
  1. Dutch Hematology congress

    Diana Spierings (Speaker)
    24-Jan-201826-Jan-2018

    Activity: Talk or presentationAcademic

View all (1) »

Prizes
  1. UMCG Innovation Prize for Research

    Diana Spierings (Recipient), 8-Jan-2019

    PrizeAcademic

View all (1) »

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