dr. C.A. (Corry-Anke) Brandsma

Assistant Professor

dr. C.A. (Corry-Anke) Brandsma
E-mail:
c.a.brandsma umcg.nl

Research

Research interests

Corry-Anke Brandsma, born in Leeuwarden in 1980, completed her master in Medical Biology at the RUG, Groningen in 2003. She was appointed as a PhD student from 2003-2007 on a joined project of the departments of Pathology and Pulmonary diseases of the UMCG on the inflammatory response in COPD. From 2007-2014 she worked as a post-doc on several research projects funded by the Dutch Lung Foundation. In 2011 she received international research fellowships from the European Respiratory Society and the Dutch Lung Foundation to work in the lab of Prof. J.C. Hogg in Vancouver (Canada). In 2014 she was appointed as staff member by the department of Pathology of the UMCG.

During her first post-doc, she focused on the role of adaptive immunity and B lymphocytes in COPD and demonstrated the presence of a smoke-induced specific immune response, which differed between COPD patients and healthy controls. After that, she steered her research focus to the role of accelerated lung aging and abnormal tissue repair in COPD, which is currently her main research focus. Using primary lung cells and lung tissue from well-characterized COPD patients and non-COPD control subjects she tries to unravel the molecular mechanisms underlying accelerated lung aging and abnormal tissue repair in COPD. For this, she uses a “multi-omics” approach combining information on changes in the genome (DNA), transcriptome (RNA, miRNA) and the proteome (protein) to identify causal molecular networks in COPD.  

Publications
  1. Genetic regulation of gene expression of MIF family members in lung tissue

    Florez-Sampedro, L., Brandsma, C-A., de Vries, M., Timens, W., Bults, R., Vermeulen, C. J., van den Berge, M., Obeidat, M., Joubert, P., Nickle, D. C., Poelarends, G. J., Faiz, A. & Melgert, B. N., 2020, In : Scientific Reports. 10, 1, p. 16980

    Research output: Contribution to journalArticleAcademicpeer-review

  2. IL-1 beta Induces a Pro-Inflammatory Fibroblast Micro-Environment That Impairs Alveolar Epithelial Organoid Formation

    Ciminieri, C., Woest, M., Reynaert, N. L., Heijink, I. H., Wardenaar, R., Spierings, D. C. J., Brandsma, C. A., Koenigshoff, M. & Gosens, R., 2020, In : American Journal of Respiratory and Critical Care Medicine. 201, 2 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  3. Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways

    Aliee, H., Massip, F., Qi, C., Stella de Biase, M., van Nijnatten, J. L., Kersten, E. T. G., Kermani, N. Z., Khuder, B., Vonk, J. M., Vermeulen, R. C. H., Neighbors, M., Tew, G. W., Grimbaldeston, M., Ten Hacken, N. H. T., Hu, S., Guo, Y., Zhang, X., Sun, K., Hiemstra, P. S., Ponder, B. A., Makela, M. J., Malmstrom, K., Rintoul, R. C., Reyfman, P. A., Theis, F. J., Brandsma, C-A., Adcock, I., Timens, W., Xu, C. J., van den Berge, M., Schwarz, R. F., Koppelman, G. H., Nawijn, M. C. & Faiz, A., 2-Sep-2020, In : medRxiv : the preprint server for health sciences. 40 p.

    Research output: Contribution to journalArticleAcademic

  4. Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study

    Milne, S., Li, X., Hernandez Cordero, A. I., Yang, C. X., Cho, M. H., Beaty, T. H., Ruczinski, I., Hansel, N. N., Bossé, Y., Brandsma, C-A., Sin, D. D. & Obeidat, M., 24-Aug-2020, In : Thorax. 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

View all (120) »

Activities
  1. MicroRNAs as regulators of lung homeostasis, abnormal repair and ageing.

    Joost Kluiver (Co-supervisor), Anke Berg, van den (Supervisor), Wim Timens (Supervisor), Corry-Anke Brandsma (Supervisor)
    2019

    Activity: ExaminationSupervision of PhD studentsAcademic

  2. Bijeenkomst Longpunt Emmen: 'Stamcellen en COPD; hope of hype?'

    Corry-Anke Brandsma (Invited speaker)
    7-Nov-2019

    Activity: Talk or presentationPopular

  3. Multi-omic approaches to understand accelerated aging in COPD

    Corry-Anke Brandsma (Speaker)
    4-Dec-2019

    Activity: Talk or presentationAcademic

View all (4) »

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