dr. C.A. (Corry-Anke) Brandsma

Assistant Professor

dr. C.A. (Corry-Anke) Brandsma
E-mail:
c.a.brandsma umcg.nl

Research

Research interests

Corry-Anke Brandsma, born in Leeuwarden in 1980, completed her master in Medical Biology at the RUG, Groningen in 2003. She was appointed as a PhD student from 2003-2007 on a joined project of the departments of Pathology and Pulmonary diseases of the UMCG on the inflammatory response in COPD. From 2007-2014 she worked as a post-doc on several research projects funded by the Dutch Lung Foundation. In 2011 she received international research fellowships from the European Respiratory Society and the Dutch Lung Foundation to work in the lab of Prof. J.C. Hogg in Vancouver (Canada). In 2014 she was appointed as staff member by the department of Pathology of the UMCG.

During her first post-doc, she focused on the role of adaptive immunity and B lymphocytes in COPD and demonstrated the presence of a smoke-induced specific immune response, which differed between COPD patients and healthy controls. After that, she steered her research focus to the role of accelerated lung aging and abnormal tissue repair in COPD, which is currently her main research focus. Using primary lung cells and lung tissue from well-characterized COPD patients and non-COPD control subjects she tries to unravel the molecular mechanisms underlying accelerated lung aging and abnormal tissue repair in COPD. For this, she uses a “multi-omics” approach combining information on changes in the genome (DNA), transcriptome (RNA, miRNA) and the proteome (protein) to identify causal molecular networks in COPD.  

Publications
  1. Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

    Brandsma, C-A., Van den Berge, M., Hackett, T-L., Brusselle, G. & Timens, W., 5-Nov-2019, In : JOURNAL OF PATHOLOGY.

    Research output: Contribution to journalReview articleAcademicpeer-review

  2. Current Smoking is Associated with Decreased Expression of miR-335-5p in Parenchymal Lung Fibroblasts

    Ong, J., van den Berg, A., Faiz, A., Boudewijn, I. M., Timens, W., Vermeulen, C. J., Oliver, B. G., Kok, K., Terpstra, M. M., van den Berge, M., Brandsma, C-A. & Kluiver, J., 2019, In : International Journal of Molecular Sciences. 20, 20, 14 p., 5176.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. The Pharmacogenomics of Inhaled Corticosteroids and Lung Function Decline in COPD

    Obeidat, M., Faiz, A., Li, X., van den Berge, M., Hansel, N. N., Joubert, P., Hao, K., Brandsma, C-A., Rafaels, N., Mathias, R., Ruczinski, I., Beaty, T. H., Barnes, K. C., Paul Man, S. F., Paré, P. D. & Sin, D. D., 19-Sep-2019, In : European Respiratory Journal.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Proteogenomics and Multi-omics Data Integration for Personalized Medicine

    Horvatovich, P., Brandsma, C-A., Suits, F., Bischoff, R. & Guryev, V., 2019, Handbook of Biomarkers and Precision Medicine. Carini, C., Fidock, M. & van Gool, A. (eds.). New York: CRC Press

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

View all (101) »

View graph of relations

ID: 233733