dr. C.A. (Corry-Anke) Brandsma

Assistant Professor

dr. C.A. (Corry-Anke) Brandsma
E-mail:
c.a.brandsma umcg.nl

Research

Research interests

Corry-Anke Brandsma, born in Leeuwarden in 1980, completed her master in Medical Biology at the RUG, Groningen in 2003. She was appointed as a PhD student from 2003-2007 on a joined project of the departments of Pathology and Pulmonary diseases of the UMCG on the inflammatory response in COPD. From 2007-2014 she worked as a post-doc on several research projects funded by the Dutch Lung Foundation. In 2011 she received international research fellowships from the European Respiratory Society and the Dutch Lung Foundation to work in the lab of Prof. J.C. Hogg in Vancouver (Canada). In 2014 she was appointed as staff member by the department of Pathology of the UMCG.

During her first post-doc, she focused on the role of adaptive immunity and B lymphocytes in COPD and demonstrated the presence of a smoke-induced specific immune response, which differed between COPD patients and healthy controls. After that, she steered her research focus to the role of accelerated lung aging and abnormal tissue repair in COPD, which is currently her main research focus. Using primary lung cells and lung tissue from well-characterized COPD patients and non-COPD control subjects she tries to unravel the molecular mechanisms underlying accelerated lung aging and abnormal tissue repair in COPD. For this, she uses a “multi-omics” approach combining information on changes in the genome (DNA), transcriptome (RNA, miRNA) and the proteome (protein) to identify causal molecular networks in COPD.  

Publications
  1. LSC-2019-Dysfunctional macrophage polarization in murine COPD exacerbation

    van der Veen, A., Roffel, M. P., Brandsma, C-A., De Jager, M., Post, E., Van den Berge, M., Boudewijn, I., De Groot, L., Lutter, R., Bracke, K., Maes, T., Melgert, B. & Heijink, I., 28-Sep-2019, In : European Respiratory Journal. 54, 2 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  2. Longitudinal effects of smoking cessation on DNA methylation in bronchial biopsies of COPD and asymptomatic smokers

    Faiz, A., Rathnayake, S. N. H., Vermeulen, C., Timens, W., Kooistra, W., Oliver, B., Willemse, B., Ten Hacken, N. H. T., Heijink, I. H., Brandsma, C-A. & Van Den Berge, M., 28-Sep-2019, In : European Respiratory Journal. 54, 3 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  3. Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1

    Brandsma, C-A., Guryev, V., Timens, W., Ciconelle, A., Postma, D. S., Bischoff, R., Johansson, M., Ovchinnikova, E. S., Malm, J., Marko-Varga, G., Fehniger, T. E., van den Berge, M. & Horvatovich, P., 14-Jan-2020, In : Thorax. 4 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution

    Duclos, G. E., Teixeira, V. H., Autissier, P., Gesthalter, Y. B., Reinders-Luinge, M. A., Terrano, R., Dumas, Y. M., Liu, G., Mazzilli, S. A., Brandsma, C-A., van den Berge, M., Janes, S. M., Timens, W., Lenburg, M. E., Spira, A., Campbell, J. D. & Beane, J., Dec-2019, In : Science Advances. 5, 12, 11 p., 3413.

    Research output: Contribution to journalArticleAcademicpeer-review

View all (108) »

Activities
  1. Bijeenkomst Longpunt Emmen: 'Stamcellen en COPD; hope of hype?'

    Corry-Anke Brandsma (Invited speaker)
    7-Nov-2019

    Activity: Talk or presentationPopular

  2. Multi-omic approaches to understand accelerated aging in COPD

    Corry-Anke Brandsma (Speaker)
    4-Dec-2019

    Activity: Talk or presentationAcademic

  3. Disturbed lung tissue repair and accelerated lung aging in COPD

    Corry-Anke Brandsma (Speaker)
    19-Nov-2019

    Activity: Talk or presentationAcademic

View all (3) »

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