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Practical matters How to find us dr. C.A. (Corry-Anke) Brandsma

Research interests

Corry-Anke Brandsma, born in Leeuwarden in 1980, completed her master in Medical Biology at the RUG, Groningen in 2003. She was appointed as a PhD student from 2003-2007 on a joined project of the departments of Pathology and Pulmonary diseases of the UMCG on the inflammatory response in COPD. From 2007-2014 she worked as a post-doc on several research projects funded by the Dutch Lung Foundation. In 2011 she received international research fellowships from the European Respiratory Society and the Dutch Lung Foundation to work in the lab of Prof. J.C. Hogg in Vancouver (Canada). In 2014 she was appointed as staff member by the department of Pathology of the UMCG.

During her first post-doc, she focused on the role of adaptive immunity and B lymphocytes in COPD and demonstrated the presence of a smoke-induced specific immune response, which differed between COPD patients and healthy controls. After that, she steered her research focus to the role of accelerated lung aging and abnormal tissue repair in COPD, which is currently her main research focus. Using primary lung cells and lung tissue from well-characterized COPD patients and non-COPD control subjects she tries to unravel the molecular mechanisms underlying accelerated lung aging and abnormal tissue repair in COPD. For this, she uses a “multi-omics” approach combining information on changes in the genome (DNA), transcriptome (RNA, miRNA) and the proteome (protein) to identify causal molecular networks in COPD.  

Publications

Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response

Determinants of expression of SARS-CoV-2 entry-related genes in upper and lower airways

Differential roles for lysyl oxidase (like), family members in chronic obstructive pulmonary disease; from gene and protein expression to function: from gene and protein expression to function

Differential Roles for Lysyl Oxidase (Like) Family Members in Chronic Obstructive Pulmonary Disease; from Gene and Protein Expression to Function

Effect of Chronological Age and Cigarette Smoke Exposure on Airway Epithelial Barrier Function

High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD

Identification of asthma associated microRNAs in bronchial biopsies

Lung Dysbiosis Is a Feature of Frequent Exacerbating COPD Patients and a Lung Gene Expression Profile of Activated Host Immune Function

MicroRNAs Associated with Chronic Mucus Hypersecretion in COPD Are Involved in Fibroblast-Epithelium Crosstalk

miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly

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Press/media

Is COPD een verzamelnaam voor verschillende ziekten?

Interview Longwijzer