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About us Practical matters How to find us dr. A.M.W.H. (Andy-Mark) Thunnissen

dr. A.M.W.H. (Andy-Mark) Thunnissen

Assistant Professor

Faculty of Science and Engineering

Telephone:

+31 50 36 34380

E-mail:

a.m.w.h.thunnissen rug.nl

Homepage ORCID Research Portal

Publications

Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling

Jóźwik, I. K., Bombino, E., Abdulmughni, A., Hartz, P., Rozeboom, H. J., Wijma, H. J., Kappl, R., Janssen, D. B., Bernhardt, R. & Thunnissen, A-M. W. H., 15-Jul-2023, (E-pub ahead of print) In: The FEBS Journal. 20 p., 16906.

Research output: Contribution to journal › Article › Academic › peer-review

Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C‐C Bond‐Forming Enzyme

Xu, G., Kunzendorf, A., Crotti, M., Rozeboom, H. J., Thunnissen, A. W. H. & Poelarends, G. J., 14-Feb-2022, In: Angewandte Chemie International Edition. 61, 8, 6 p., e202113970.

Research output: Contribution to journal › Article › Academic › peer-review

The Role of Tryptophan in π Interactions in Proteins: An Experimental Approach

Shao, J., Kuiper, B. P., Thunnissen, A-M. W. H., Cool, R. H., Zhou, L., Huang, C., Dijkstra, B. W. & Broos, J., Sept-2022, In: Journal of the American Chemical Society. 144, 30, p. 13815-13822 8 p., 04986.

Research output: Contribution to journal › Article › Academic › peer-review

Biocatalytic Enantioselective Hydroaminations Enabling Synthesis of N-Arylalkyl-Substituted L-Aspartic Acids

Abidin, M. M., Thangavelu, S., Bothof, L., Tepper, P., Thunnissen, A. & Poelarends, G. J., Aug-2021, In: Organic & Biomolecular Chemistry. 19, 29, p. 6407–6411 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Computational Redesign of an ω-Transaminase from Pseudomonas jessenii for Asymmetric Synthesis of Enantiopure Bulky Amines

Meng, Q., Ramírez-Palacios, C., Capra, N., Hooghwinkel, M. E., Thallmair, S., Rozeboom, H. J., Thunnissen, A. M. W. H., Wijma, H. J., Marrink, S. J. & Janssen, D. B., Aug-2021, In: ACS Catalysis. 11, 17, p. 10733-10747 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Unlocking Asymmetric Michael Additions in an Archetypical Class I Aldolase by Directed Evolution

Kunzendorf, A., Xu, G., Van Der Velde, J. J. H., Rozeboom, H. J., Thunnissen, A. W. H. & Poelarends, G. J., 5-Nov-2021, In: ACS Catalysis. 11, 21, p. 13236-13243 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Using Mutability Landscapes To Guide Enzyme Thermostabilization

Guo, C., Ni, Y., Biewenga, L., Pijning, T., Thunnissen, A-M. W. H. & Poelarends, G. J., 5-Jan-2021, In: ChemBioChem. 22, 1, p. 170-175 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Cofactor Binding Dynamics Influence the Catalytic Activity and Selectivity of an Artificial Metalloenzyme

Villarino, L., Chordia, S., Alonso-Cotchico, L., Reddem, E., Zhou, Z., Thunnissen, A. M. W. H., Maréchal, J-D. & Roelfes, G., 18-Sept-2020, In: ACS Catalysis. 10, 20, p. 11783-11790 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners Catalyzed by an Engineered C-N Lyase

Zhang, J., Grandi, E., Fu, H., Thangavelu, S., Bothof, L., Tepper, P. G., Thunnissen, A-M. W. H. & Poelarends, G. J., 2-Jan-2020, In: Angewandte Chemie International Edition. 59, 1, p. 429-435 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Robust ω-Transaminases by Computational Stabilization of the Subunit Interface

Meng, Q., Capra, N., Palacio, C. M., Lanfranchi, E., Otzen, M., Van Schie, L. Z., Rozeboom, H. J., Thunnissen, A. M. W. H., Wijma, H. J. & Janssen, D. B., 6-Mar-2020, In: ACS Catalysis. 10, 5, p. 2915-2928 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

All (69) publications

Press/media

Kunstmatige intelligentie kraakt een van de grote raadsels in de biologie

Andy Thunnissen

16/09/2022

Press/Media: Expert Comment › Popular

3D ontdekkingstocht in de wereld van eiwitten

Andy Thunnissen

14/01/2017

Press/Media: Other › Popular

All (2) press/media

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