prof. dr. A.M.H. (AnneMieke) Boots

Professor

Research

Research interests

Understanding immunology of ageing in relation to the development of age-associated autoimmune diseases in the elderly. The focus of the research is on definition of (cellular) biomarkers as predictors of disease, relapse and recovery in giant cell arteritis, polymyalgia rheumatica and RA. The Groningen Longevity / SENEX cohort supported by the UMCG Healthy ageing initiative was set up to study ageing- associated immune alterations. A scientific collaboration was set-up with the National Institute for Public Health and the Environment (Bilthoven, The Netherlands) to study booster vaccinations in pre elderly individuals. In collaboration with researchers at RadboudUMC Nijmegen a collaboration was set-up to study the effect of exercise on the immune system in the elderly.

Publications
  1. Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+T cells in aged humans

    van der Geest, K. S. M., Abdulahad, W. H., Teteloshvili, N., Tete, S. M., Peters, J. H., Horst, G., Lorencetti, P. G., Bos, N. A., Lambeck, A., Roozendaal, C., Kroesen, B-J., Koenen, H. J. P. M., Joosten, I., Brouwer, E. & Boots, A. M. H., Oct-2015, In : Aging Cell. 14, 5, p. 744-753 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Immuno-miRs: critical regulators of T-cell development, function and ageing

    Kroesen, B-J., Teteloshvili, N., Smigielska, K., Brouwer, E., Boots, A., van den Berg, A. & Kluiver, J., Jan-2015, In : Immunology. 144, 1, p. 1-10 10 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

  3. Aging disturbs the balance between effector and regulatory CD4+T cells

    van der Geest, K. S. M., Abdulahad, W. H., Tete, S. M., Lorencetti, P. G., Horst, G., Bos, N. A., Kroesen, B-J., Brouwer, E. & Boots, A. M. H., Dec-2014, In : Experimental Gerontology. 60, p. 190-196 7 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. The influence of ageing on the development and management of rheumatoid arthritis

    Boots, A. M. H., Maier, A. B., Stinissen, P., Masson, P., Lories, R. J. & De Keyser, F., Oct-2013, In : NATURE REVIEWS RHEUMATOLOGY. 9, 10, p. 604-613 10 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

  5. Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study

    van der Geest, K. S. M., Wang, Q., Eijsvogels, T. M. H., Koenen, H. J. P., Joosten, I., Brouwer, E., Hopman, M. T. E., Jacobs, J. F. M. & Boots, A. M. H., 22-Feb-2017, In : Immunity & ageing : I & A. 14, 13 p., 5.

    Research output: Contribution to journalArticleAcademicpeer-review

  6. Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders

    Te Velde, A. A., Bezema, T., van Kampen, A. H. C., Kraneveld, A. D., 't Hart, B. A., van Middendorp, H., Hack, E. C., van Montfrans, J. M., Belzer, C., Jans-Beken, L., Pieters, R. H., Knipping, K., Huber, M., Boots, A. M. H., Garssen, J., Radstake, T. R., Evers, A. W. M., Prakken, B. J. & Joosten, I., 12-Dec-2016, In : Frontiers in Immunology. 7, 9 p., 587.

    Research output: Contribution to journalArticleAcademicpeer-review

View all (157) »

Press / Media
  1. kenners over vaccinatie

    Annemieke Boots

    13/09/2018

    1 media contribution

    Press/Media: Expert CommentPopular

  2. Biocahier ons afweersysteem

    Annemieke Boots

    01/09/2018

    1 media contribution

    Press/Media: Expert CommentPopular

  3. Goed werk voor academici

    Annemieke Boots

    01/07/2015

    1 media contribution

    Press/Media: Public Engagement ActivitiesPopular

View all (12) »

Activities
  1. faciltator year 2 and 3 medicine

    Annemieke Boots (Examiner)
    1-Sep-201831-Jul-2019

    Activity: ExaminationExamination/teaching third partiesProfessional

  2. basis cursus immunologie UMC Groningen

    Annemieke Boots (Speaker)
    24-Jan-201925-Jan-2019

    Activity: Talk or presentationProfessional

  3. Peter Verhoeven

    Elisabeth Brouwer (Host), Abraham Rutgers (Host), Coen Stegeman (Host), Johannes Sanders (Host), Annemieke Boots (Host), Peter Heeringa (Host)
    31-Jan-2019

    Activity: Hosting a visitorProfessional

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Prizes
  1. Vaccines and InfecTious diseases in the Ageing popuLations (VITAL)

    Annemieke Boots (Recipient) & Liesbeth Brouwer (Recipient), 2018

    Prize: Other distinctionAcademic

  2. The Polymyalgia Rheumatica Bursitis Study

    Niels Geest, van der (Recipient), Liesbeth Brouwer (Recipient) & Annemieke Boots (Recipient), 9-Jan-2018

    PrizeAcademic

  3. Failure of Immune regulation in Giant Cell Arteritis

    Rosanne Reitsema (Recipient), Liesbeth Brouwer (Recipient), Peter Heeringa (Recipient) & Annemieke Boots (Recipient), 24-Jul-2017

    PrizeAcademic

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