prof. dr. A.M.H. (AnneMieke) Boots

Professor

prof. dr. A.M.H. (AnneMieke) Boots
E-mail:
m.boots umcg.nl

Research

Research interests

Background: Prof Annemieke M. H. Boots PhD is a cellular immunologist who graduated in the Life Sciences in 1985 and defended her thesis on peptide vaccine development in 1991 at Utrecht University in the Netherlands. She then joined Organon, a pharmaceutical company in the Netherlands to specialize in drug discovery for Rheumatoid arthritis/Cancer. In 2009 she was appointed adjunct professor at the Groningen University to liaise industry and academia in clinical translational research. In 2011 she left Industry and became a full professor and principal Investigator at the UMCG in Groningen. She teamed up with Dr Liesbeth Brouwer to initiate research on the contribution of immune aging to the development of large vessel vasculitis, a very serious disease occurring exclusvely in older adults.

Research Interests: The focus of the researchgroup is on definition of biomarkers as predictors of disease, relapse and recovery in giant cell arteritis and the overlapping condition polymyalgia rheumatica. The Groningen GCA/PMR/SENEX cohort was set-up in 2010 and participants are followed for clinical and immunological parameters over time.  Scientific collaborations  with the National Institute for Public Health and the Environment (RIVM, Bilthoven, The Netherlands) were set-up to study booster vaccinations in pre elderly individuals and to identify predictive immune biomarker profiles of frailty and morbidity with ageing.  In 2015 our group partnered in the EU RELENT consortium to study the aging immune system in vasculitic diseases. Since 2019 we partner in the IMI-2 Consortium Vaccines and InfecTious diseases in the Ageing popuLation (VITAL) coordinated by the RIVM (Prof. Debbie van Baarle).

Publications
  1. Immuno-miRs: critical regulators of T-cell development, function and ageing

    Kroesen, B-J., Teteloshvili, N., Smigielska, K., Brouwer, E., Boots, A., van den Berg, A. & Kluiver, J., Jan-2015, In : Immunology. 144, 1, p. 1-10 10 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

  2. High angiopoietin-2 levels associate with arterial inflammation and long-term glucocorticoid requirement in polymyalgia rheumatica

    van Sleen, Y., Boots, A. M. H., Abdulahad, W. H., Bijzet, J., Sandovici, M., van der Geest, K. S. M. & Brouwer, E., Jan-2020, In : Rheumatology. 59, 1, p. 176-184 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Frailty is associated with elevated CRP trajectories and higher numbers of neutrophils and monocytes

    Samson, L. D., Boots, A. M. H., Verschuren, W. M. M., Picavet, H. S. J., Engelfriet, P. & Buisman, A-M., 1-Oct-2019, In : Experimental Gerontology. 125, 9 p., 110674.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Markers of angiogenesis and macrophage products for predicting disease course and monitoring vascular inflammation in giant cell arteritis

    van Sleen, Y., Sandovici, M., Abdulahad, W. H., Bijzet, J., van der Geest, K. S. M., Boots, A. M. H. & Brouwer, E., Aug-2019, In : Rheumatology. 58, 8, p. 1383-1392 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  5. Aging disturbs the balance between effector and regulatory CD4+T cells

    van der Geest, K. S. M., Abdulahad, W. H., Tete, S. M., Lorencetti, P. G., Horst, G., Bos, N. A., Kroesen, B-J., Brouwer, E. & Boots, A. M. H., Dec-2014, In : Experimental Gerontology. 60, p. 190-196 7 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  6. The influence of ageing on the development and management of rheumatoid arthritis

    Boots, A. M. H., Maier, A. B., Stinissen, P., Masson, P., Lories, R. J. & De Keyser, F., Oct-2013, In : NATURE REVIEWS RHEUMATOLOGY. 9, 10, p. 604-613 10 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

  7. Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study

    van der Geest, K. S. M., Wang, Q., Eijsvogels, T. M. H., Koenen, H. J. P., Joosten, I., Brouwer, E., Hopman, M. T. E., Jacobs, J. F. M. & Boots, A. M. H., 22-Feb-2017, In : Immunity & ageing : I & A. 14, 13 p., 5.

    Research output: Contribution to journalArticleAcademicpeer-review

  8. Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders

    Te Velde, A. A., Bezema, T., van Kampen, A. H. C., Kraneveld, A. D., 't Hart, B. A., van Middendorp, H., Hack, E. C., van Montfrans, J. M., Belzer, C., Jans-Beken, L., Pieters, R. H., Knipping, K., Huber, M., Boots, A. M. H., Garssen, J., Radstake, T. R., Evers, A. W. M., Prakken, B. J. & Joosten, I., 12-Dec-2016, In : Frontiers in Immunology. 7, 9 p., 587.

    Research output: Contribution to journalArticleAcademicpeer-review

View all (176) »

Press / Media
  1. Oproep van artsen in het UMCG: Beweeg en eet gezond, dat helpt ons immuunsysteem en beschermt tegen corona

    Mieke Boots

    04/04/2020

    1 Media contribution

    Press/Media: Public Engagement ActivitiesPopular

  2. kenners over vaccinatie

    Annemieke Boots

    13/09/2018

    1 Media contribution

    Press/Media: Expert CommentPopular

  3. Biocahier ons afweersysteem

    Annemieke Boots

    01/09/2018

    1 Media contribution

    Press/Media: Expert CommentPopular

View all (13) »

Activities
  1. Vaccinatie in relatie tot autoimmuniteit

    Mieke Boots (Speaker)

    5-Feb-2021

    Activity: Talk or presentationAcademic

  2. European Federation of Immunological Societies (External organisation)

    Mieke Boots (Member)

    20192021

    Activity: MembershipMembership of committeeAcademic

  3. Immunowell Foundation , Utrecht , Netherlands. (External organisation)

    Annemieke Boots (Member)

    20142021

    Activity: MembershipMembership of networkPopular

View all (48) »

ID: 340093