prof. dr. A.M.H. (AnneMieke) Boots

Hoogleraar

Research

Research interests

Understanding immunology of ageing in relation to the development of age-associated autoimmune diseases in the elderly. The focus of the research is on definition of (cellular) biomarkers as predictors of disease, relapse and recovery in giant cell arteritis, polymyalgia rheumatica and RA. The Groningen Longevity / SENEX cohort supported by the UMCG Healthy ageing initiative was set up to study ageing- associated immune alterations. A scientific collaboration was set-up with the National Institute for Public Health and the Environment (Bilthoven, The Netherlands) to study booster vaccinations in pre elderly individuals. In collaboration with researchers at RadboudUMC Nijmegen a collaboration was set-up to study the effect of exercise on the immune system in the elderly.

Publications
  1. Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+T cells in aged humans

    van der Geest, K. S. M., Abdulahad, W. H., Teteloshvili, N., Tete, S. M., Peters, J. H., Horst, G., Lorencetti, P. G., Bos, N. A., Lambeck, A., Roozendaal, C., Kroesen, B-J., Koenen, H. J. P. M., Joosten, I., Brouwer, E. & Boots, A. M. H. Oct-2015 In : Aging Cell. 14, 5, p. 744-753 10 p.

    Research output: Contribution to journalArticle

  2. Immuno-miRs: critical regulators of T-cell development, function and ageing

    Kroesen, B-J., Teteloshvili, N., Smigielska, K., Brouwer, E., Boots, A., van den Berg, A. & Kluiver, J. Jan-2015 In : Immunology. 144, 1, p. 1-10 10 p.

    Research output: Contribution to journalReview article

  3. Aging disturbs the balance between effector and regulatory CD4+T cells

    van der Geest, K. S. M., Abdulahad, W. H., Tete, S. M., Lorencetti, P. G., Horst, G., Bos, N. A., Kroesen, B-J., Brouwer, E. & Boots, A. M. H. Dec-2014 In : Experimental Gerontology. 60, p. 190-196 7 p.

    Research output: Contribution to journalArticle

  4. The influence of ageing on the development and management of rheumatoid arthritis

    Boots, A. M. H., Maier, A. B., Stinissen, P., Masson, P., Lories, R. J. & De Keyser, F. Oct-2013 In : NATURE REVIEWS RHEUMATOLOGY. 9, 10, p. 604-613 10 p.

    Research output: Contribution to journalReview article

  5. Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study

    van der Geest, K. S. M., Wang, Q., Eijsvogels, T. M. H., Koenen, H. J. P., Joosten, I., Brouwer, E., Hopman, M. T. E., Jacobs, J. F. M. & Boots, A. M. H. 22-Feb-2017 In : Immunity & ageing : I & A. 14, 13 p., 5

    Research output: Contribution to journalArticle

  6. Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders

    Te Velde, A. A., Bezema, T., van Kampen, A. H. C., Kraneveld, A. D., 't Hart, B. A., van Middendorp, H., Hack, E. C., van Montfrans, J. M., Belzer, C., Jans-Beken, L., Pieters, R. H., Knipping, K., Huber, M., Boots, A. M. H., Garssen, J., Radstake, T. R., Evers, A. W. M., Prakken, B. J. & Joosten, I. 12-Dec-2016 In : Frontiers in Immunology. 7, 9 p., 587

    Research output: Contribution to journalArticle

View all (157) »

Press / Media
  1. Goed werk voor academici

    Annemieke Boots

    01/07/2015

    1 media contribution

    Press/Media: Public Engagement Activities

  2. Immunowell; member science reflection group

    Annemieke Boots

    01/05/2015

    1 media contribution

    Press/Media: Public Engagement Activities

  3. publicatie Telegraaf 7 februari 2015

    Annemieke Boots

    07/02/2015

    1 media contribution

    Press/Media: Research

View all (10) »

Activities
  1. Visiting Eerste Kamer Den Haag

    Boots, A. (Other)
    27-Jan-2015

    Activity: ProfessionalOther

  2. Immuun regulatie in ouderen; een kwetsbaar evenwicht

    Boots, A. (Speaker)
    1-Dec-2009

    Activity: Talk or presentationInvited talk

  3. T cell function in aging and in age- associated autoimmunity

    Boots, A. (Speaker)
    23-Jun-2011

    Activity: Talk or presentationInvited talk

View all (27) »

Prizes
  1. Unrestricted Grant MSD

    Annemieke Boots (Recipient) & GGM Kallenberg (Recipient), 2009

    Prize: Other distinction

View all (10) »

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