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How to find us prof. dr. A.M.H. (AnneMieke) Boots

Research interests

Background: Prof Annemieke M. H. Boots PhD is a cellular immunologist who graduated in the Life Sciences in 1985 and defended her thesis on peptide vaccine development in 1991 at Utrecht University in the Netherlands. She then joined Organon, a pharmaceutical company in the Netherlands to specialize in drug discovery for Rheumatoid arthritis/Cancer. In 2009 she was appointed adjunct professor at the Groningen University to liaise industry and academia in clinical translational research. In 2011 she left Industry and became a full professor and principal Investigator at the UMCG in Groningen. She teamed up with Dr Liesbeth Brouwer to initiate research on the contribution of immune aging to the development of large vessel vasculitis, a very serious disease occurring exclusvely in older adults.

Research Interests: The focus of the researchgroup is on definition of biomarkers as predictors of disease, relapse and recovery in giant cell arteritis and the overlapping condition polymyalgia rheumatica. The Groningen GCA/PMR/SENEX cohort was set-up in 2010 and participants are followed for clinical and immunological parameters over time.  Scientific collaborations  with the National Institute for Public Health and the Environment (RIVM, Bilthoven, The Netherlands) were set-up to study booster vaccinations in pre elderly individuals and to identify predictive immune biomarker profiles of frailty and morbidity with ageing.  In 2015 our group partnered in the EU RELENT consortium to study the aging immune system in vasculitic diseases. Since 2019 we partner in the IMI-2 Consortium Vaccines and InfecTious diseases in the Ageing popuLation (VITAL) coordinated by the RIVM (Prof. Debbie van Baarle).

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Publications

Immuno-miRs: critical regulators of T-cell development, function and ageing

High angiopoietin-2 levels associate with arterial inflammation and long-term glucocorticoid requirement in polymyalgia rheumatica

Frailty is associated with elevated CRP trajectories and higher numbers of neutrophils and monocytes

Markers of angiogenesis and macrophage products for predicting disease course and monitoring vascular inflammation in giant cell arteritis

Aging disturbs the balance between effector and regulatory CD4+T cells

The influence of ageing on the development and management of rheumatoid arthritis

Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study

Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders

A Distinct Macrophage Subset Mediating Tissue Destruction and Neovascularization in Giant Cell Arteritis: Implication of the YKL‐40 ‐ IL‐13 Receptor α2 Axis: Implication of the YKL-40 - IL-13 Receptor α2 Axis

Association of the CXCL9-CXCR3 and CXCL13-CXCR5 axes with B-cell trafficking in giant cell arteritis and polymyalgia rheumatica

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Press/media

Oproep van artsen in het UMCG: Beweeg en eet gezond, dat helpt ons immuunsysteem en beschermt tegen corona

kenners over vaccinatie

Biocahier ons afweersysteem

Goed werk voor academici

Immunowell; member science reflection group

publicatie Telegraaf 7 februari 2015

debat chronische ziekten in de Balie in Amsterdam

Goede balans tussen aanval en verdediging

Goede balans tussen aanval en verdediging

Veroudering van het Immuunsysteem

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