prof. dr. A.J. (Tineke) Oldehinkel

Professor Lifecourse Epidemiology of Common Mental Disorders

prof. dr. A.J. (Tineke) Oldehinkel


Research interests

I am a professor of Lifecourse Epidemiology of Common Mental Disorders. Being trained as an (experimental) psychologist, (bio)statistician and epidemiologist, I have always worked on the crossroads of medical and social sciences. My affinity with multi- and interdisciplinary research is reflected in my leadership of the Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), which performs research at the junction of various disciplines, with the aim to unravel psychobiological processes involved in the onset and course of common mental problems, in particular affective disorders. In addition, I am principal investigator of the longitudinal study TRAILS (Tracking Adolescents’ Individual Lives Survey,, which was set up over fourteen years ago to chart and explain the mental health and development of adolescents and young adults, and involves researchers working in various scientific domains and institutes in the Netherlands and abroad.

My inspiration as a scientist is driven by a great deal of curiosity as well as the desire to better understand and predict the intricacies of the onset of course of mental health problems in order to improve prevention and care. My research mainly focuses on the interplay of individual psychobiological vulnerability and resilience factors, conceived as the result of genetic endowment and past experiences, and environmental challenges in the development and course of depressive symptoms. This work is based on observational data collected in large longitudinal epidemiological surveys, complemented with studies involving many repeated measurements in smaller groups to assess temporal patterns of specific mood-related factors and the effects of interventions thereon. An example of such a study concerns the question how adolescents lose the ability to experience pleasure and may gain it back again (

  1. Emotion-Based Learning by Iowa and Bangor Gambling Tasks: Similar but not the same?

    Heininga, V. E., Nederhof, E., Roekel, van, E., Laceulle, O. & Oldehinkel, T., Sep-2019, (Accepted/In press) 13 p.

    Research output: Book/ReportReportProfessional

  2. The bidirectional association between sleep problems and anxiety symptoms in adolescents: a TRAILS report

    Narmandakh, A., Roest, A. M., Jonge, de, P. & Oldehinkel, T., 2020, In : Sleep Medicine. 67, p. 39-46 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Unique developmental trajectories of risk behaviors in adolescence and associated outcomes in young adulthood

    Peeters, M., Oldehinkel, A., Veenstra, R. & Vollebergh, W., 13-Nov-2019, In : PLoS ONE. 14, 11, 19 p., e0225088.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Meta-analysis of genome-wide association studies of anxiety disorders

    Otowa, T., Hek, K., Lee, M., Byrne, E. M., Mirza, S. S., Nivard, M. G., Bigdeli, T., Aggen, S. H., Adkins, D., Wolen, A., Fanous, A., Keller, M. C., Castelao, E., Kutalik, Z., der Auwera, S. V., Homuth, G., Nauck, M., Teumer, A., Milaneschi, Y., Hottenga, J-J., Direk, N., Hofman, A., Uitterlinden, A., Mulder, C. L., Henders, A. K., Medland, S. E., Gordon, S., Heath, A. C., Madden, P. A. F., Pergadia, M. L., van der Most, P. J., Nolte, I. M., van Oort, F. V. A., Hartman, C. A., Oldehinkel, A. J., Preisig, M., Grabe, H. J., Middeldorp, C. M., Penninx, B. W. J. H., Boomsma, D., Martin, N. G., Montgomery, G., Maher, B. S., van den Oord, E. J., Wray, N. R., Tiemeier, H. & Hettema, J. M., Oct-2016, In : Molecular Psychiatry. 21, 10, p. 1391–1399 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review


    Martin, N., Otowa, T., Lee, M., Hartman, C., Oldehinkel, A., Preisig, M., Grabe, H. J., Middeldorp, C., Penninx, B., Boomsma, D., Montgomery, G., Wray, N., Tiemeier, H. & Hettema, J., Oct-2017, In : European Neuropsychopharmacology. 27, p. S501 1 p.

    Research output: Contribution to journalMeeting AbstractAcademic

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  1. Graduate School Medical Sciences - General (Organisational unit)

    Tineke Oldehinkel (Member)
    2018 → …

    Activity: MembershipMembership of committeeAcademic

  2. Waarom worden jonge mensen depressief?

    Tineke Oldehinkel (Speaker)

    Activity: Talk or presentationProfessional

  3. Development MOOC 'Young people and their mental health'

    Tineke Oldehinkel (Other), Maaike Meurs (Other), Tom Spits (Other)

    Activity: OtherPopular

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Press / Media
  1. Editor top tips

    Tineke Oldehinkel


    1 Media contribution

    Press/Media: Expert CommentAcademic

  2. Jong en depressief. Hoe vind je de weg terug als je op de bodem zit?

    Tineke Oldehinkel


    1 Media contribution

    Press/Media: Expert CommentPopular

  3. Depressie bij jongeren

    Albertine Oldehinkel & Robert A. Schoevers


    2 Media contributions

    Press/Media: Expert CommentPopular

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