prof. dr. A.J. (Tineke) Oldehinkel

Professor Lifecourse Epidemiology of Common Mental Disorders


Research interests

I am a professor of Lifecourse Epidemiology of Common Mental Disorders. Being trained as an (experimental) psychologist, (bio)statistician and epidemiologist, I have always worked on the crossroads of medical and social sciences. My affinity with multi- and interdisciplinary research is reflected in my leadership of the Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), which performs research at the junction of various disciplines, with the aim to unravel psychobiological processes involved in the onset and course of common mental problems, in particular affective disorders. In addition, I am principal investigator of the longitudinal study TRAILS (Tracking Adolescents’ Individual Lives Survey,, which was set up over fourteen years ago to chart and explain the mental health and development of adolescents and young adults, and involves researchers working in various scientific domains and institutes in the Netherlands and abroad.

My inspiration as a scientist is driven by a great deal of curiosity as well as the desire to better understand and predict the intricacies of the onset of course of mental health problems in order to improve prevention and care. My research mainly focuses on the interplay of individual psychobiological vulnerability and resilience factors, conceived as the result of genetic endowment and past experiences, and environmental challenges in the development and course of depressive symptoms. This work is based on observational data collected in large longitudinal epidemiological surveys, complemented with studies involving many repeated measurements in smaller groups to assess temporal patterns of specific mood-related factors and the effects of interventions thereon. An example of such a study concerns the question how adolescents lose the ability to experience pleasure and may gain it back again (

  1. Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability (vol 21, pg 1161, 2018)

    23andMe Res Team, Psychiat Genomics Consortium Int & Int Cannabis Consortium, Jul-2019, In : Nature neuroscience. 22, 7, p. 1196 1 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. A catalog of genetic loci associated with kidney function from analyses of a million individuals

    Lifelines Cohort Study, Wuttke, M., Li, Y., Li, M., Sieber, K. B., Feitosa, M. F., Gorski, M., Tin, A., Wang, L., Chu, A. Y., Hoppmann, A., Kirsten, H., Giri, A., Chai, J-F., Sveinbjornsson, G., Tayo, B. O., Nutile, T., Fuchsberger, C., Marten, J., Cocca, M., Ghasemi, S., Xu, Y., Horn, K., Noce, D., Van der Most, P. J., Sedaghat, S., Yu, Z., Akiyama, M., Afaq, S., Ahluwalia, T. S., Almgren, P., Amin, N., Arnlov, J., Bakker, S. J. L., Bansal, N., De Borst, M. H., De Vries, A. P. J., Demirkan, A., Gansevoort, R. T., Hartman, C. A., Huang, W., Nolte, I. M., Oldehinkel, A. J., Penninx, B. W. J. H., Prins, B. P., Smith, A. V., Van der Harst, P., Verweij, N., Wang, Y. X., Xu, L., Snieder, H. & Thio, C. H. L., Jun-2019, In : Nature Genetics. 51, 6, p. 957-+ 19 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

    Lifelines Cohort Study, 10-Apr-2019, In : Human Molecular Genetics. 19 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

    COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Soc Sci Grp & Lifelines Cohort, Apr-2019, In : Nature Genetics. 51, 4, p. 636-+ 16 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  5. The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

    EAGLE Consortium, EGG Consortium, EGG Membership & EAGLE Membership, Mar-2019, In : European Journal of Epidemiology. 34, 3, p. 279-300 22 p.

    Research output: Contribution to journalArticleAcademicpeer-review

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  1. Graduate School Medical Sciences - General (Organisational unit)

    Tineke Oldehinkel (Member)
    2018 → …

    Activity: MembershipMembership of committeeAcademic

  2. Waarom worden jonge mensen depressief?

    Tineke Oldehinkel (Speaker)

    Activity: Talk or presentationProfessional

  3. Development MOOC 'Young people and their mental health'

    Tineke Oldehinkel (Other), Maaike Meurs (Other), Tom Spits (Other)

    Activity: OtherPopular

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Press / Media
  1. Jong en depressief. Hoe vind je de weg terug als je op de bodem zit?

    Tineke Oldehinkel


    1 media contribution

    Press/Media: Expert CommentPopular

  2. Depressie bij jongeren

    Tineke Oldehinkel & Robert Schoevers


    2 media contributions

    Press/Media: Expert CommentPopular

  3. Free online course about mental health for young people

    Tineke Oldehinkel & Maaike Meurs


    1 media contribution

    Press/Media: Public Engagement ActivitiesPopular

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