prof. dr. A.J. (Tineke) Oldehinkel

Professor Lifecourse Epidemiology of Common Mental Disorders

prof. dr. A.J. (Tineke) Oldehinkel
Telephone:
E-mail:
a.j.oldehinkel umcg.nl

Research

Research interests

I am a professor of Lifecourse Epidemiology of Common Mental Disorders. Being trained as an (experimental) psychologist, (bio)statistician and epidemiologist, I have always worked on the crossroads of medical and social sciences. My affinity with multi- and interdisciplinary research is reflected in my leadership of the Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), which performs research at the junction of various disciplines, with the aim to unravel psychobiological processes involved in the onset and course of common mental problems, in particular affective disorders. In addition, I am principal investigator of the longitudinal study TRAILS (Tracking Adolescents’ Individual Lives Survey, www.trails.nl), which was set up over fourteen years ago to chart and explain the mental health and development of adolescents and young adults, and involves researchers working in various scientific domains and institutes in the Netherlands and abroad.

My inspiration as a scientist is driven by a great deal of curiosity as well as the desire to better understand and predict the intricacies of the onset of course of mental health problems in order to improve prevention and care. My research mainly focuses on the interplay of individual psychobiological vulnerability and resilience factors, conceived as the result of genetic endowment and past experiences, and environmental challenges in the development and course of depressive symptoms. This work is based on observational data collected in large longitudinal epidemiological surveys, complemented with studies involving many repeated measurements in smaller groups to assess temporal patterns of specific mood-related factors and the effects of interventions thereon. An example of such a study concerns the question how adolescents lose the ability to experience pleasure and may gain it back again (www.nofunnoglory.nl).

Publications
  1. Associations of autozygosity with a broad range of human phenotypes

    Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., Bartz, T. M., Baumbach, C., Biino, G., Bixley, M. J., Brumat, M., Chai, J-F., Corre, T., Cousminer, D. L., Dekker, A. M., Eccles, D. A., van Eijk, K. R., Fuchsberger, C., Gao, H., Germain, M., Gordon, S. D., de Haan, H. G., Harris, S. E., Hofer, E., Huerta-Chagoya, A., Igartua, C., Jansen, I. E., Jia, Y., Kacprowski, T., Karlsson, T., Kleber, M. E., Li, S. A., Li-Gao, R., Mahajan, A., Matsuda, K., Meidtner, K., Meng, W., Montasser, M. E., van der Most, P. J., Munz, M., Nutile, T., Palviainen, T., Prasad, G., Prasad, R. B., Priyanka, T. D. S., Rizzi, F., Salvi, E., Sapkota, B. R., Shriner, D., Skotte, L., Smart, M. C., Smith, A. V., van der Spek, A., Spracklen, C. N., Strawbridge, R. J., Tajuddin, S. M., Trompet, S., Turman, C., Verweij, N., Viberti, C., Wang, L., Warren, H. R., Wootton, R. E., Yanek, L. R., Yao, J., Yousri, N. A., Zhao, W., Adeyemo, A. A., Afaq, S., Aguilar-Salinas, C. A., Akiyama, M., Albert, M. L., Allison, M. A., Alver, M., Aung, T., Azizi, F., Bentley, A. R., Boeing, H., Boerwinkle, E., Borja, J. B., de Borst, G. J., Bottinger, E. P., Broer, L., Campbell, H., Chanock, S., Chee, M-L., Chen, G., Chen, Y-D. I., Chen, Z., Chiu, Y-F., Cocca, M., Collins, F. S., Concas, M. P., Corley, J., Cugliari, G., van Dam, R. M., Damulina, A., Daneshpour, M. S., Day, F. R., Delgado, G. E., Dhana, K., Doney, A. S. F., Dörr, M., Doumatey, A. P., Dzimiri, N., Ebenesersdóttir, S. S., Elliott, J., Elliott, P., Ewert, R., Felix, J. F., Fischer, K., Freedman, B. I., Girotto, G., Goel, A., Gögele, M., Goodarzi, M. O., Graff, M., Granot-Hershkovitz, E., Grodstein, F., Guarrera, S., Gudbjartsson, D. F., Guity, K., Gunnarsson, B., Guo, Y., Hagenaars, S. P., Haiman, C. A., Halevy, A., Harris, T. B., Hedayati, M., van Heel, D. A., Hirata, M., Höfer, I., Hsiung, C. A., Huang, J., Hung, Y-J., Ikram, M. A., Jagadeesan, A., Jousilahti, P., Kamatani, Y., Kanai, M., Kerrison, N. D., Kessler, T., Khaw, K-T., Khor, C. C., de Kleijn, D. P. V., Koh, W-P., Kolcic, I., Kraft, P., Krämer, B. K., Kutalik, Z., Kuusisto, J., Langenberg, C., Launer, L. J., Lawlor, D. A., Lee, I-T., Lee, W-J., Lerch, M. M., Li, L., Liu, J., Loh, M., London, S. J., Loomis, S., Lu, Y., Luan, J., Mägi, R., Manichaikul, A. W., Manunta, P., Másson, G., Matoba, N., Mei, X. W., Meisinger, C., Meitinger, T., Mezzavilla, M., Milani, L., Millwood, I. Y., Momozawa, Y., Moore, A., Morange, P-E., Moreno-Macías, H., Mori, T. A., Morrison, A. C., Muka, T., Murakami, Y., Murray, A. D., de Mutsert, R., Mychaleckyj, J. C., Nalls, M. A., Nauck, M., Neville, M. J., Nolte, I. M., Ong, K. K., Orozco, L., Padmanabhan, S., Pálsson, G., Pankow, J. S., Pattaro, C., Pattie, A., Polasek, O., Poulter, N., Pramstaller, P. P., Quintana-Murci, L., Räikkönen, K., Ralhan, S., Rao, D. C., van Rheenen, W., Rich, S. S., Ridker, P. M., Rietveld, C. A., Robino, A., van Rooij, F. J. A., Ruggiero, D., Saba, Y., Sabanayagam, C., Sabater-Lleal, M., Sala, C. F., Salomaa, V., Sandow, K., Schmidt, H., Scott, L. J., Scott, W. R., Sedaghati-Khayat, B., Sennblad, B., van Setten, J., Sever, P. J., Sheu, W. H-H., Shi, Y., Shrestha, S., Shukla, S. R., Sigurdsson, J. K., Sikka, T. T., Singh, J. R., Smith, B. H., Stančáková, A., Stanton, A., Starr, J. M., Stefansdottir, L., Straker, L., Sulem, P., Sveinbjornsson, G., Swertz, M. A., Taylor, A. M., Taylor, K. D., Terzikhan, N., Tham, Y-C., Thorleifsson, G., Thorsteinsdottir, U., Tillander, A., Tracy, R. P., Tusié-Luna, T., Tzoulaki, I., Vaccargiu, S., Vangipurapu, J., Veldink, J. H., Vitart, V., Völker, U., Vuoksimaa, E., Wakil, S. M., Waldenberger, M., Wander, G. S., Wang, Y. X., Wareham, N. J., Wild, S., Yajnik, C. S., Yuan, J-M., Zeng, L., Zhang, L., Zhou, J., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Becker, D. M., Lehne, B., Bennett, D. A., van den Berg, L. H., Berndt, S. I., Bharadwaj, D., Bielak, L. F., Bochud, M., Boehnke, M., Bouchard, C., Bradfield, J. P., Brody, J. A., Campbell, A., Carmi, S., Caulfield, M. J., Cesarini, D., Chambers, J. C., Chandak, G. R., Cheng, C-Y., Ciullo, M., Cornelis, M., Cusi, D., Smith, G. D., Deary, I. J., Dorajoo, R., van Duijn, C. M., Ellinghaus, D., Erdmann, J., Eriksson, J. G., Evangelou, E., Evans, M. K., Faul, J. D., Feenstra, B., Feitosa, M., Foisy, S., Franke, A., Friedlander, Y., Gasparini, P., Gieger, C., Gonzalez, C., Goyette, P., Grant, S. F. A., Griffiths, L. R., Groop, L., Gudnason, V., Gyllensten, U., Hakonarson, H., Hamsten, A., van der Harst, P., Heng, C-K., Hicks, A. A., Hochner, H., Huikuri, H., Hunt, S. C., Jaddoe, V. W. V., De Jager, P. L., Johannesson, M., Johansson, Å., Jonas, J. B., Jukema, J. W., Junttila, J., Kaprio, J., Kardia, S. L. R., Karpe, F., Kumari, M., Laakso, M., van der Laan, S. W., Lahti, J., Laudes, M., Lea, R. A., Lieb, W., Lumley, T., Martin, N. G., März, W., Matullo, G., McCarthy, M. I., Medland, S. E., Merriman, T. R., Metspalu, A., Meyer, B. F., Mohlke, K. L., Montgomery, G. W., Mook-Kanamori, D., Munroe, P. B., North, K. E., Nyholt, D. R., O'connell, J. R., Ober, C., Oldehinkel, A. J., Palmas, W., Palmer, C., Pasterkamp, G. G., Patin, E., Pennell, C. E., Perusse, L., Peyser, P. A., Pirastu, M., Polderman, T. J. C., Porteous, D. J., Posthuma, D., Psaty, B. M., Rioux, J. D., Rivadeneira, F., Rotimi, C., Rotter, J. I., Rudan, I., Den Ruijter, H. M., Sanghera, D. K., Sattar, N., Schmidt, R., Schulze, M. B., Schunkert, H., Scott, R. A., Shuldiner, A. R., Sim, X., Small, N., Smith, J. A., Sotoodehnia, N., Tai, E-S., Teumer, A., Timpson, N. J., Toniolo, D., Tregouet, D-A., Tuomi, T., Vollenweider, P., Wang, C. A., Weir, D. R., Whitfield, J. B., Wijmenga, C., Wong, T-Y., Wright, J., Yang, J., Yu, L., Zemel, B. S., Zonderman, A. B., Perola, M., Magnusson, P. K. E., Uitterlinden, A. G., Kooner, J. S., Chasman, D. I., Loos, R. J. F., Franceschini, N., Franke, L., Haley, C. S., Hayward, C., Walters, R. G., Perry, J. R. B., Esko, T., Helgason, A., Stefansson, K., Joshi, P. K., Kubo, M. & Wilson, J. F., 31-Oct-2019, In : Nature Communications. 10, 1, 17 p., 4957.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Association of Use of Oral Contraceptives With Depressive Symptoms Among Adolescents and Young Women.

    Wit, de, A., Booij, S. H., Giltay, E., Joffe, H., Schoevers, R. A. & Oldehinkel, T., 2-Oct-2019, In : Jama psychiatry.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. A healthy peer status: Peer preference, not popularity, predicts lower systemic inflammation in adolescence

    de Bruine, M., Giletta, M., Denissen, J. J. A., Sijtsema, J. J. & Oldehinkel, A. J., 9-Aug-2019, In : Psychoneuroendocrinology. 109, 104402.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

    Evangelou, E., Gao, H., Chu, C., Ntritsos, G., Blakeley, P., Butts, A. R., Pazoki, R., Suzuki, H., Koskeridis, F., Yiorkas, A. M., Karaman, I., Elliott, J., Luo, Q., Aeschbacher, S., Bartz, T. M., Baumeister, S. E., Braund, P. S., Brown, M. R., Brody, J. A., Clarke, T-K., Dimou, N., Faul, J. D., Homuth, G., Jackson, A. U., Kentistou, K. A., Joshi, P. K., Lemaitre, R. N., Lind, P. A., Lyytikäinen, L-P., Mangino, M., Milaneschi, Y., Nelson, C. P., Nolte, I. M., Perälä, M-M., Polasek, O., Porteous, D., Ratliff, S. M., Smith, J. A., Stančáková, A., Teumer, A., Tuominen, S., Thériault, S., Vangipurapu, J., Whitfield, J. B., Wood, A., Yao, J., Yu, B., Zhao, W., Arking, D. E., Auvinen, J., Liu, C., Männikkö, M., Risch, L., Rotter, J. I., Snieder, H., Veijola, J., Blakemore, A. I., Boehnke, M., Campbell, H., Conen, D., Eriksson, J. G., Grabe, H. J., Guo, X., van der Harst, P., Hartman, C. A., Hayward, C., Heath, A. C., Jarvelin, M-R., Kähönen, M., Kardia, S. L. R., Kühne, M., Kuusisto, J., Laakso, M., Lahti, J., Lehtimäki, T., McIntosh, A. M., Mohlke, K. L., Morrison, A. C., Martin, N. G., Oldehinkel, A. J., Penninx, B. W. J. H., Psaty, B. M., Raitakari, O. T., Rudan, I., Samani, N. J., Scott, L. J., Spector, T. D., Verweij, N., Weir, D. R., Wilson, J. F., Levy, D., Tzoulaki, I., Bell, J. D., Matthews, P. M., Rothenfluh, A., Desrivières, S., Schumann, G. & Elliott, P., Sep-2019, In : Nature Human Behaviour. 3, 9, p. 950-961 12 p.

    Research output: Contribution to journalArticleAcademicpeer-review

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Activities
  1. Graduate School Medical Sciences - General (Organisational unit)

    Tineke Oldehinkel (Member)
    2018 → …

    Activity: MembershipMembership of committeeAcademic

  2. Waarom worden jonge mensen depressief?

    Tineke Oldehinkel (Speaker)
    27-Mar-2018

    Activity: Talk or presentationProfessional

  3. Development MOOC 'Young people and their mental health'

    Tineke Oldehinkel (Other), Maaike Meurs (Other), Tom Spits (Other)
    Feb-2017Jan-2018

    Activity: OtherPopular

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Press / Media
  1. Editor top tips

    Tineke Oldehinkel

    16/10/2019

    1 media contribution

    Press/Media: Expert CommentAcademic

  2. Jong en depressief. Hoe vind je de weg terug als je op de bodem zit?

    Tineke Oldehinkel

    13/07/2019

    1 media contribution

    Press/Media: Expert CommentPopular

  3. Depressie bij jongeren

    Tineke Oldehinkel & Robert Schoevers

    24/03/201826/03/2018

    2 media contributions

    Press/Media: Expert CommentPopular

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