dr. A. (Albert) Guskov
Assistant Professor / Group leader (NWO Vidi Fellow)
Research
Research units:
Publications
Binding and transport of D-aspartate by the glutamate transporter homologue GltTk
Arkhipova, V. I., Trinco, G., Thijs, E., Jensen, S., Slotboom, D. & Guskov, A., 1-May-2019, In : eLife. 8, 12 p., e45286.Research output: Contribution to journal › Article › Academic › peer-review
Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on β-mannan possess distinct manno-oligosaccharide binding profiles
Ejby, M., Guskov, A., Pichler, M. J., Zanten, G. C., Schoof, E., Saburi, W., Slotboom, D. J. & Abou Hachem, M., Jul-2019, In : Molecular Microbiology. 112, 1, p. 114-130 17 p., 14257.Research output: Contribution to journal › Article › Academic › peer-review
Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM
Rempel, S., Colucci, E., Gier, J-W. D., Guskov, A. & Slotboom, D., 2-Aug-2018, In : Nature Communications. 9, 1, 8 p., 3038.Research output: Contribution to journal › Article › Academic › peer-review
Cryo-EM structure of the human neutral amino acid transporter ASCT2
Garaeva, A., Oostergetel, G., Gati, C., Guskov, A., Batista Paulino, C. & Slotboom, D., 5-Jun-2018, In : Nature Structural & Molecular Biology. 25, p. 515-521Research output: Contribution to journal › Article › Academic › peer-review
Functional and structural characterization of an ECF-type ABC transporter for vitamin B12
Luís da Silva Santos Guimarães, J. A., Rempel, S., Mous, S. T. M., Tambascia Pereira, C., ter Beek, J., Gier, J-W. D., Guskov, A. & Slotboom, D., 2018, In : eLife. 7, 16 p., e35828.Research output: Contribution to journal › Article › Academic › peer-review
The structural basis of proton driven zinc transport by ZntB
Gati, C., Stetsenko, A., Slotboom, D., Scheres, S. & Guskov, A., 3-Nov-2017, In : Nature Communications. 8, 8 p., 1313.Research output: Contribution to journal › Article › Academic › peer-review
Analysis of the quality of crystallographic data and the limitations of structural models
Arkhipova, V. I., Guskov, A. & Slotboom, D., Dec-2017, In : The Journal of General Physiology. 149, 12, 13 p.Research output: Contribution to journal › Article › Academic › peer-review
A general mechanism of ribosome dimerization revealed by single-particle cryo-electron microscopy
Franken, L., Oostergetel, G., Pijning, T., Puri, P., Arkhipova, V. I., Boekema, E., Poolman, B. & Guskov, A., 28-Sep-2017, In : Nature Communications. 8, 11 p., 722.Research output: Contribution to journal › Article › Academic › peer-review
An Overview of the Top Ten Detergents Used for Membrane Protein Crystallization
Stetsenko, A. & Guskov, A., 1-Jul-2017, In : Crystals. 7, 7, p. 1-16 16 p., 197.Research output: Contribution to journal › Article › Academic › peer-review
Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk
Guskov, A., Jensen, S., Faustino, I., Marrink, S. J. & Slotboom, D. J., 2016, In : Nature Communications. 7, p. 1-6 6 p., 13420.Research output: Contribution to journal › Article › Academic › peer-review
Size exclusion chromatography with multi-angle laser light scattering (SEC-MALLS) to determine protein oligomeric states
Guskov, A. & Slotboom, D., Jan-2016, From molecules to living organisms: an interplay between biology and physics: Lecture Notes of the Les Houches School of Physics: Volume 102, July 2014. Pebay-Peyroula, E., Nury, H., Parcy, F., Ruigrok, R. W. H., Ziegler, C. & Cugliandolo, L. F. (eds.). Oxford University Press, p. 169-183 6. (Lecture Notes of the Les Houches School of Physics; vol. 102).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic
Structural insight in the toppling mechanism of an energy-coupling factor transporter
Swier, L. J. Y. M., Guskov, A. & Slotboom, D. J., 30-Mar-2016, In : Nature Communications. 7, p. 1-11 12 p., 11072.Research output: Contribution to journal › Article › Academic › peer-review
Pnu Transporters: Ain't They SWEET?
Jähme, M., Guskov, A. & Slotboom, D. J., Feb-2016, In : Trends in Biochemical Sciences. 41, 2, p. 117-118 2 p.Research output: Contribution to journal › Article › Academic › peer-review
The twisted relation between Pnu and SWEET transporters
Jähme, M., Guskov, A. & Slotboom, D., 7-Mar-2015, In : Trends in Biochemical Sciences. 40, 4, p. 183-188 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Structure-Based Design of Potent Small-Molecule Binders to the S-Component of the ECF Transporter for Thiamine
Swier, L. J. Y. M., Monjas, L., Guskov, A., de Voogd, A. R., Erkens, G. B., Slotboom, D. J. & Hirsch, A. K. H., 23-Mar-2015, In : ChemBioChem. 16, 5, p. 819-826 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Structural diversity of ABC transporters
ter Beek, J., Guskov, A. & Slotboom, D. J., Apr-2014, In : Journal of general physiology. 143, 4, p. 419-435 17 p.Research output: Contribution to journal › Article › Academic › peer-review
Structure and pharmacological studies of the anaesthetic 1-(3-n-butoxypropyl)-4-benzoyloxypiperidin hydrochloride and its complex with beta-cyclodextrin in solution. NMR and IR-spectroscopy data
Kemelbekov, U., Saipov, A., Abdildanova, A., Ospanov, I., Luo, Y., Guskov, A., Saenger, W., Imachova, S., Nasyrova, S. & Pichkhadze, G., Dec-2013, In : Journal of inclusion phenomena and macrocyclic chemistry. 77, 1-4, p. 249-257 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Crystal structure of a substrate-free aspartate transporter
Jensen, S., Guskov, A., Rempel, S., Hänelt, I. & Slotboom, D. J., Oct-2013, In : Nature Structural & Molecular Biology. 20, 10, p. 1224-1226 3 p.Research output: Contribution to journal › Article › Academic › peer-review
Functional Diversity of Tandem Substrate-Binding Domains in ABC Transporters from Pathogenic Bacteria
Fulyani, F., Schuurman-Wolters, G. K., Vujicic - Zagar, A., Guskov, A., Slotboom, D-J. & Poolman, B., 8-Oct-2013, In : Structure. 21, 10, p. 1879-1888 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Exploring the structure and function of Thermotoga maritima CorA reveals the mechanism of gating and ion selectivity in Co2+/Mg2+ transport
Nordin, N., Guskov, A., Phua, T., Sahaf, N., Xia, Y., Lu, S., Eshaghi, H. & Eshaghi, S., 1-May-2013, In : Biochemical Journal. 451, 3, p. 365-374 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Comprehensive analysis and identification of the human STIM1 domains for structural and functional studies
How, J., Zhang, A., Phillips, M., Reynaud, A., Lu, S. Y., Pan, L. X., Ho, H. T., Yau, Y. H., Guskov, A., Pervushin, K., Shochat, S. G. & Eshaghi, S., 8-Jan-2013, In : PLoS ONE. 8, 1, 12 p., e53979.Research output: Contribution to journal › Article › Academic › peer-review
Structural basis of ligand recognition in 5-HT3 receptors
Kesters, D., Thompson, A. J., Brams, M., van Elk, R., Spurny, R., Geitmann, M., Villalgordo, J. M., Guskov, A., Danielson, U. H., Lummis, S. C. R., Smit, A. B. & Ulens, C., Jan-2013, In : Embo Reports. 14, 1, p. 49-56 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Structural insights into the mechanisms of Mg2+ uptake, transport, and gating by CorA
Guskov, A., Nordin, N., Reynaud, A., Engman, H., Lundbäck, A-K., Jong, A. J. O., Cornvik, T., Phua, T. & Eshaghi, S., 6-Nov-2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 45, p. 18459-18464 6 p.Research output: Contribution to journal › Article › Academic › peer-review
The mechanisms of Mg2+ and Co2+ transport by the CorA family of divalent cation transporters
Guskov, A. & Eshaghi, S., 2012, In : Current topics in membranes. 69, p. 393-414 22 p.Research output: Contribution to journal › Article › Academic › peer-review
Structural basis of cyanobacterial photosystem II Inhibition by the herbicide terbutryn
Broser, M., Glöckner, C., Gabdulkhakov, A., Guskov, A., Buchta, J., Kern, J., Müh, F., Dau, H., Saenger, W. & Zouni, A., 6-May-2011, In : The Journal of Biological Chemistry. 286, 18, p. 15964-15972 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Lipids in photosystem II: Multifunctional cofactors
Kern, J. & Guskov, A., 13-Apr-2011, In : Journal of Photochemistry and Photobiology B: Biology. 104, 1-2, p. 19-34 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein
Brams, M., Gay, E. A., Sáez, J. C., Guskov, A., van Elk, R., van der Schors, R. C., Peigneur, S., Tytgat, J., Strelkov, S. V., Smit, A. B., Yakel, J. L. & Ulens, C., 11-Feb-2011, In : The Journal of Biological Chemistry. 286, 6, p. 4420-4428 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Pharmacology and structures of the free base of the anaesthetic kazcaine and its complex with beta-cyclodextrin
Kemelbekov, U. S., Hagenbach, A., Lentz, D., Imachova, S. O., Pichkhadze, G. M., Rustembekov, Z. I., Beketov, K. M., Praliev, K. D., Gabdulkhakov, A., Guskov, A. & Saenger, W., Dec-2010, In : Journal of inclusion phenomena and macrocyclic chemistry. 68, 3-4, p. 323-330 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Crystal structure of monomeric photosystem II from Thermosynechococcus elongatus at 3.6-a resolution
Broser, M., Gabdulkhakov, A., Kern, J., Guskov, A., Müh, F., Saenger, W. & Zouni, A., 20-Aug-2010, In : The Journal of Biological Chemistry. 285, 34, p. 26255-26262 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Recent progress in the crystallographic studies of photosystem II
Guskov, A., Gabdulkhakov, A., Broser, M., Glöckner, C., Hellmich, J., Kern, J., Frank, J., Müh, F., Saenger, W. & Zouni, A., 26-Apr-2010, In : Chemphyschem : a European journal of chemical physics and physical chemistry. 11, 6, p. 1160-1171 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Lipids in the Structure of Photosystem I, Photosystem II and the Cytochrome b6f Complex
Kern, J., Zouni, A., Guskov, A. & Krauss, N., 2009, Lipids in Photosynthesis: Essential and Regulatory Functions. Wada, H. & Murata, N. (eds.). Dordrecht, The Netherlands: Springer, p. 203-241 39 p. (Advances in Photosynthesis and Respiration; vol. 30).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic
Probing the accessibility of the Mn(4)Ca cluster in photosystem II: Channels calculation, noble gas derivatization, and cocrystallization with DMSO
Gabdulkhakov, A., Guskov, A., Broser, M., Kern, J., Müh, F., Saenger, W. & Zouni, A., 9-Sep-2009, In : Structure. 17, 9, p. 1223-34 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Cyanobacterial photosystem II at 2.9-A resolution and the role of quinones, lipids, channels and chloride
Guskov, A., Kern, J., Gabdulkhakov, A., Broser, M., Zouni, A. & Saenger, W., Mar-2009, In : Nature Structural & Molecular Biology. 16, 3, p. 334-342 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Prizes
NWO Start Up grant
Guskov, Albert (Recipient), 6-Feb-2018
Prize: Fellowship awarded competitively › Academic
Press / Media
TB-bacterie haalt vitamine binnen via een sluis - Nieuw inzicht in functioneren van bacteriën en cellen
26/03/2020
1 item of Media coverage
Press/Media: Public Engagement Activities › Popular
TB-bacterie haalt vitamine binnen via een sluis - Nieuw inzicht in functioneren van bacteriën en cellen
25/03/2020
1 item of Media coverage
Press/Media: Public Engagement Activities › Popular
Tuberculosis bacterium uses sluice to import vitamins- New insights into the physiology of bacteria and cells
25/03/2020
1 item of Media coverage
Press/Media: Public Engagement Activities › Popular
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