dr. A. Diepstra

pathologist and post-doc researcher

dr. A. Diepstra
E-mail:
a.diepstra umcg.nl

Research

Research interests

I am a hematopathologist at the University Medical Center Groningen and a principal investigator in the SALL (stem cells, aging, leukemia and lymphoma) program of the CRCG (Cancer Research Center Groningen). My main research interest involves malignant lymphoma, in particular Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In my PhD thesis "Classical Hodgkin lymphoma: population based studies on HLA and EBV (2007)" I discovered that the HLA system is intricately involved in Hodgkin lymphoma susceptibility, pathogenesis and prognosis and published these findings in the Lancet and Journal of Clinical Oncology. I secured three Dutch Cancer Society grants to do functional follow-up studies on these findings. Fruitful international collaborations involve the Interlymph consortium on genome wide association studies, the Lymphoma group of the EORTC and various groups in the UK, Canada and the US. My areas of expertise are: immunology, tumor cell biology, association studies and molecular diagnostics in pathology.   

Publications
  1. Treatment of patients with MYC rearrangement positive large B-cell lymphoma with R-CHOP plus lenalidomide: results of a multicenter HOVON phase II trial

    Chamuleau, M. E. D., Burggraaff, C. N., Nijland, M., Bakunina, K., Mous, R., Lugtenburg, P. J., Dierickx, D., van Imhoff, G. W., Vermaat, J. S. P., Marijt, E. A. F., Visser, O., Mandigers, C., Bilgin, Y. M., Beeker, A., Durian, M. F., van Rees, B., Bohmer, L. H., Tick, L. W., Boersma, R. S., Snijders, T. J. F., Schouten, H. C., Koene, H. R., de Jongh, E., Hijmering, N., Diepstra, A., van den Berg, A., Arens, A. I. J., Huijbregts, J., Hoekstra, O., Zijlstra, J. M., de Jong, D. & Kersten, M. J., 19-Dec-2019, In : Haematologica.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Primary and acquired resistance mechanisms to immune checkpoint inhibition in Hodgkin lymphoma

    Veldman, J., Visser, L., Berg, A. V. D. & Diepstra, A., 11-Nov-2019, In : CANCER TREATMENT REVIEWS. 82, 9 p., 101931.

    Research output: Contribution to journalReview articleAcademicpeer-review

  3. Complement activation and long-term graft function in ABO-incompatible kidney transplantation

    van Sandwijk, M. S., Klooster, A., Ten Berge, I. J., Diepstra, A., Florquin, S., Hoelbeek, J. J., Bemelman, F. J. & Sanders, J-S., 27-Oct-2019, In : World journal of nephrology. 8, 6, p. 95-108 14 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. CD27(+)CD38(hi) B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients

    von Borstel, A., Land, J., Abdulahad, W. H., Rutgers, A., Stegeman, C. A., Diepstra, A., Heeringa, P. & Sanders, J. S., 24-Sep-2019, In : Frontiers in Immunology. 10, 10 p., 2221.

    Research output: Contribution to journalArticleAcademicpeer-review

View all (122) »

Press / Media
  1. Een lab dat levens redt - a lab that saves lives

    Arjan Diepstra

    29/04/2016

    1 item of Media coverage

    Press/Media: Public Engagement ActivitiesPopular

View all (1) »

Activities
  1. Het Hodgkin lymfoom

    Arjan Diepstra (Speaker)
    6-Nov-2018

    Activity: Talk or presentationProfessional

  2. 13th Dutch Hematology Congress

    Arjan Diepstra (Chair)
    23-Jan-2019

    Activity: Participating in or organising an eventParticipation in conferenceAcademic

  3. 13th Dutch Hematology Congress

    Arjan Diepstra (Invited speaker)
    25-Jan-2019

    Activity: Participating in or organising an eventParticipation in conferenceAcademic

View all (9) »

Prizes
  1. Karl Musshoff Prize

    Arjan Diepstra (Recipient), 24-Oct-2016

    PrizeAcademic

View all (1) »

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