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How to find us dr. A. (Arjan) Diepstra

Research interests

I am a hematopathologist at the University Medical Center Groningen and a principal investigator in the SALL (stem cells, aging, leukemia and lymphoma) program of the CRCG (Cancer Research Center Groningen). My main research interest involves malignant lymphoma, in particular Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In my PhD thesis "Classical Hodgkin lymphoma: population based studies on HLA and EBV (2007)" and follow-up studies, I discovered that the HLA system is intricately involved in Hodgkin lymphoma susceptibility, pathogenesis and prognosis and published these findings in the Lancet, Journal of Clinical Oncology and Blood. I secured three Dutch Cancer Society grants to do functional follow-up studies on these findings. Fruitful international collaborations involve the Interlymph consortium on genome wide association studies, the Lymphoma group of the EORTC and various groups in the UK, Canada and the US. My areas of expertise are: immunology, tumor cell biology, association studies and molecular diagnostics in pathology.   

Publications

Combining brentuximab vedotin with dexamethasone, high-dose cytarabine and cisplatin as salvage treatment in relapsed or refractory Hodgkin lymphoma: the phase II HOVON/LLPC Transplant BRaVE study

Extranodal Natural Killer/T-cell Lymphoma, Nasal Type: Diagnosis and Treatment

Genetically Raised Circulating Bilirubin Levels and Risk of Ten Cancers: A Mendelian Randomization Study

Interaction between ERAP Alleles and HLA Class I Types Support a Role of Antigen Presentation in Hodgkin Lymphoma Development

Non-small cell lung cancer infiltrated with chronic myelomonocytic leukemia: a molecular diagnostic challenge to recognize mixed cancers in a single biopsy

Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [F-18]FDG PET/CT

Soluble PD-L1 is a promising disease biomarker but does not reflect tissue expression in classic Hodgkin lymphoma

Biopsy-Controlled Non-Invasive Quantification of Collagen Type VI in Kidney Transplant Recipients: A Post-Hoc Analysis of the MECANO Trial

Cell-free DNA as biomarker in Hodgkin lymphoma patients

Diagnostic performance of FDG-PET/CT of post-transplant lymphoproliferative disorder and factors affecting diagnostic yield

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Press/media

Een lab dat levens redt - a lab that saves lives