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About us Practical matters How to find us dr. A. (Arjan) Diepstra

Research interests

I am a hematopathologist at the University Medical Center Groningen and a principal investigator in the SALL (stem cells, aging, leukemia and lymphoma) program of the CRCG (Cancer Research Center Groningen). My main research interest involves malignant lymphoma, in particular Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In my PhD thesis "Classical Hodgkin lymphoma: population based studies on HLA and EBV (2007)" and follow-up studies, I discovered that the HLA system is intricately involved in Hodgkin lymphoma susceptibility, pathogenesis and prognosis and published these findings in the Lancet, Journal of Clinical Oncology and Blood. I secured three Dutch Cancer Society grants to do functional follow-up studies on these findings. Fruitful international collaborations involve the Interlymph consortium on genome wide association studies, the Lymphoma group of the EORTC and various groups in the UK, Canada and the US. My areas of expertise are: immunology, tumor cell biology, association studies and molecular diagnostics in pathology.   

Publications

Clonal hematopoiesis and UBA1 mutations in individuals with biopsy-proven giant cell arteritis and population-based controls

Demographics and additional haematologic cancers of patients with histiocytic/dendritic cell neoplasms

A population-based study of transformed marginal zone lymphoma: identifying outcome-related characteristics

A significant proportion of classic Hodgkin lymphoma recurrences represents clonally unrelated second primary lymphoma

Clinical outcome and humoral immune responses of β-thalassemia major patients with severe iron overload to SARS-CoV-2 infection and vaccination: a prospective cohort study

Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia.

Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Elevated serum TARC levels precede classic Hodgkin lymphoma diagnosis by several years

Expression of interleukin-6 in synovial tissue of patients with polymyalgia rheumatica

Genomic profiling of post-transplant lymphoproliferative disorders using cell-free DNA

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Press/media

Serum TARC Levels Increased Years Prior to Hodgkin Lymphoma Diagnosis

Serumspiegels TARC-eiwit al jaren voor diagnose Hodgkin lymfoom verhoogd

Hodgkin lymphoma can be diagnosed much earlier

Video Interview for the Video Journal of Haematological Oncology on TARC in Hodgkin lymphoma

Een lab dat levens redt - a lab that saves lives

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