dr. A. Diepstra

pathologist and post-doc researcher

dr. A. Diepstra
E-mail:
a.diepstra umcg.nl

Research

Research interests

I am a hematopathologist at the University Medical Center Groningen and a principal investigator in the SALL (stem cells, aging, leukemia and lymphoma) program of the CRCG (Cancer Research Center Groningen). My main research interest involves malignant lymphoma, in particular Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In my PhD thesis "Classical Hodgkin lymphoma: population based studies on HLA and EBV (2007)" and follow-up studies, I discovered that the HLA system is intricately involved in Hodgkin lymphoma susceptibility, pathogenesis and prognosis and published these findings in the Lancet, Journal of Clinical Oncology and Blood. I secured three Dutch Cancer Society grants to do functional follow-up studies on these findings. Fruitful international collaborations involve the Interlymph consortium on genome wide association studies, the Lymphoma group of the EORTC and various groups in the UK, Canada and the US. My areas of expertise are: immunology, tumor cell biology, association studies and molecular diagnostics in pathology.   

Publications
  1. Rosetting T cells in Hodgkin lymphoma are activated by immunological synapse components HLA class II and CD58

    Veldman, J., Visser, L., Huberts-Kregel, M., Muller, N., Hepkema, B., Van den Berg, A. & Diepstra, A., 26-Jun-2020, In : Blood. 15 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Cell-free DNA as biomarker in Hodgkin lymphoma patients

    Tan, G. W., Terpstra, M. M., Kok, K., Diepstra, A., van den Berg, A. & Plattel, W., Mar-2020, In : Klinische Pädiatrie. 232, 2, p. 89-89 1 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  3. Microenvironment, cross-talk, and immune escape mechanisms

    Visser, L., Veldman, J., Poppema, S., van den Berg, A. & Diepstra, A., 1-Jan-2020, Hematologic Malignancies. SPRINGER, p. 69-86 18 p. (Hematologic Malignancies).

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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Press / Media
  1. Een lab dat levens redt - a lab that saves lives

    Arjan Diepstra

    29/04/2016

    1 item of Media coverage

    Press/Media: Public Engagement ActivitiesPopular

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Activities
  1. Interlymph annual meeting

    Arjan Diepstra (Invited speaker)
    16-Sep-2020

    Activity: Participating in or organising an eventOrganising an eventAcademic

  2. European Organization on Research and Treatment of Cancer (External organisation)

    Arjan Diepstra (Member)
    2010

    Activity: MembershipMembership of networkAcademic

  3. Dutch Society of Hematopathology (External organisation)

    Arjan Diepstra (Member)
    2016

    Activity: MembershipMembership of networkProfessional

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Prizes
  1. Translational research Transplant-BRAVE trial

    Arjan Diepstra (Recipient), 2020

    Prize: National/international honourAcademic

  2. Side studies EORTC-1537-LYMG COBRA trial

    Arjan Diepstra (Recipient), Jul-2020

    PrizeAcademic

  3. Karl Musshoff Prize

    Arjan Diepstra (Recipient), 24-Oct-2016

    PrizeAcademic

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