dr. A. (Arjan) Diepstra

academic hematopathologist and associate professor

Faculty of Medical Sciences

Telephone:

+31 50 361 4684

E-mail:

a.diepstra umcg.nl

Homepage ORCID Research Portal

Research interests

I am a hematopathologist at the University Medical Center Groningen and a principal investigator in the SALL (stem cells, aging, leukemia and lymphoma) program of the CRCG (Cancer Research Center Groningen). My main research interest involves malignant lymphoma, in particular Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In my PhD thesis "Classical Hodgkin lymphoma: population based studies on HLA and EBV (2007)" and follow-up studies, I discovered that the HLA system is intricately involved in Hodgkin lymphoma susceptibility, pathogenesis and prognosis and published these findings in the Lancet, Journal of Clinical Oncology and Blood. I secured three Dutch Cancer Society grants to do functional follow-up studies on these findings. Fruitful international collaborations involve the Interlymph consortium on genome wide association studies, the Lymphoma group of the EORTC and various groups in the UK, Canada and the US. My areas of expertise are: immunology, tumor cell biology, association studies and molecular diagnostics in pathology.

Publications

Expression of interleukin-6 in synovial tissue of patients with polymyalgia rheumatica

Jiemy, W. F. , Zhang, A. , Boots, A. M. H. , Heeringa, P. , Sandovici, M. , Diepstra, A. , Hein, S. , Dasgupta, B. , Brouwer, E. & van der Geest, K. S. , Mar-2023 , In: Annals of the Rheumatic Diseases. 82 , 3 , p. 440-442 12 p.

Research output: Contribution to journal › Letter › Academic › peer-review

M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and improving mitochondrial metabolism

Weinhäuser, I. , Pereira-Martins, D. A. , Almeida, L. Y. , Hilberink, J. R. , Silveira, D. R. A. , Quek, L. , Ortiz, C. , Araujo, C. L. , Bianco, T. M. , Lucena-Araujo, A. , Mota, J. M. , Hogeling, S. M. , Sternadt, D. , Visser, N. , Diepstra, A. , Ammatuna, E. , Huls, G. , Rego, E. M. & Schuringa, J. J. , 14-Apr-2023 , In: Science Advances. 9 , 15 , 21 p. , eadf8522.

Research output: Contribution to journal › Article › Academic › peer-review

The value of thymus and activation related chemokine immunohistochemistry in classic Hodgkin lymphoma diagnostics

Kilsdonk, M. , Veldman, C. , Rosati, S. , Plattel, W. & Diepstra, A. , Feb-2023 , In: Histopathology. 82 , 3 , p. 495-503 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

9p24.1 alterations and programmed cell death 1 ligand 1 expression in early stage unfavourable classical Hodgkin lymphoma: an analysis from the German Hodgkin Study Group NIVAHL trial

Gerhard-Hartmann, E. , Goergen, H. , Bröckelmann, P. J. , Mottok, A. , Steinmüller, T. , Grund, J. , Zamò, A. , Ben-Neriah, S. , Sasse, S. , Borchmann, S. , Fuchs, M. , Borchmann, P. , Reinke, S. , Engert, A. , Veldman, J. , Diepstra, A. , Klapper, W. & Rosenwald, A. , Jan-2022 , In: British Journal of Haematology. 196 , 1 , p. 116-126 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

A gene expression-based model predicts outcome in children with intermediate-risk classical Hodgkin lymphoma

Johnston, R. L. , Mottok, A. , Chan, F. C. , Jiang, A. , Diepstra, A. , Visser, L. , Telenius, A. , Gascoyne, R. D. , Friedman, D. L. , Schwartz, C. L. , Kelly, K. M. , Scott, D. W. , Horton, T. M. & Steidl, C. , 10-Feb-2022 , In: Blood. 139 , 6 , p. 889-893 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

A Rare Case of Epstein-Barr Virus-Positive T-Cell Lymphoma in the Skin of an Immunocompromised Patient

van Eijk, L. E. , Koldijk, M. J. , van Kester, M. S. , Diepstra, A. & Diercks, G. F. H. , 1-Feb-2022 , In: American journal of dermatopathology. 44 , 2 , p. E19-E22 4 p.

Research output: Contribution to journal › Article › Academic › peer-review

Biological and Clinical Implications of Gene-Expression Profiling in Diffuse Large B-Cell Lymphoma: A Proposal for a Targeted BLYM-777 Consortium Panel as Part of a Multilayered Analytical Approach

de Groot, F. A. , de Groen, R. A. L. , van den Berg, A. , Jansen, P. M. , Lam, K. H. , Mutsaers, P. G. N. J. , van Noesel, C. J. M. , Chamuleau, M. E. D. , Stevens, W. B. C. , Plaça, J. R. , Mous, R. , Kersten, M. J. , van der Poel, M. M. W. , Tousseyn, T. , Woei-A-Jin, F. J. S. H. , Diepstra, A. , Nijland, M. & Vermaat, J. S. P. , 7-Apr-2022 , In: Cancers. 14 , 8 , 23 p. , 1857.

Research output: Contribution to journal › Review article › peer-review

Bone marrow necrosis as complication of treatment with all-trans retinoic acid and arsenic trioxide: case report and implications for treatment

Hazenberg, C. L. E. , Diepstra, A. , Santing, M. , Huls, G. A. & Ammatuna, E. , May-2022 , In: Annals of Hematology. 101 , p. 1133–1134 2 p.

Research output: Contribution to journal › Letter › Academic › peer-review

CD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2: Characterizing CD4+ T cells in Hodgkin lymphoma

Veldman, J. , Placa, J. R. , Chong, L. , Terpstra, M. M. , Mastik, M. , van Kempen, L. C. , Kok, K. , Aoki, T. , Steidl, C. , van den Berg, A. , Visser, L. & Diepstra, A. , 31-Dec-2022 , In: OncoImmunology. 11 , 1 , 11 p. , 2033433.

Research output: Contribution to journal › Article › Academic › peer-review

Cell-of-origin classification using the Hans and Lymph2Cx algorithms in primary cutaneous large B-cell lymphomas

Schrader, A. M. R. , de Groen, R. A. L. , Willemze, R. , Jansen, P. M. , Quint, K. D. , van Wezel, T. , van Eijk, R. , Ruano, D. , Tensen, C. P. , Hauben, E. , Woei-A-Jin, F. J. S. H. , Busschots, A. M. , van den Berg, A. , Diepstra, A. , Vermeer, M. H. & Vermaat, J. S. P. , Mar-2022 , In: Virchows Archiv : an International Journal of Pathology. 480 , p. 667–675 9 p.

Research output: Contribution to journal › Article › Academic › peer-review