Skip to ContentSkip to Navigation
Part of University of Groningen
Science LinXScience Linx News

New chemical reaction greener and less expensive

01 December 2014

Researchers from the Stratingh Institute for Chemistry at the University of Groningen have discovered a sustainable way of producing a reaction that is important to the pharmaceutical industry .

‘Instead of a complex chemical reaction that produces all kinds of waste substances, we use a simple reaction with an inexpensive iron-based catalyst, whereby water is the only waste substance. You can understand how enthusiastic we are’, explains organic chemist Ben Feringa.

Barta, Feringa and Yan
Barta, Feringa and Yan

He and assistant professor Katalin Barta have written an article for Nature Communications (26 November), reporting that the research group has found a new way of producing amines (carbon-nitrogen compounds) directly from an alcohol (carbon-oxygen-hydrogen compounds).

Amines are an important raw material in fine chemistry and in the pharmaceutical industry. The method described by the Barta and Feringa team is already in use, but with catalysts that contain expensive or toxic metals. ‘We were familiar with the way the reaction works and knew about the iron compound. But despite numerous attempts around the world, nobody had managed to use iron as the catalytic agent in this application. We have now found the right conditions for producing the direct coupling reaction from an alcohol and amine using this iron catalyst.’

Apart from being cheaper, less toxic and not needing extra chemical reactions that produce waste substances, the new catalyst also works in an environmentally friendly solvent, CPME. ‘CPME is known to be highly durable.’

Feringa thinks that the new catalyst will be used for converting alcohol compounds from biomass into high-grade chemical products, including medicines, and may even replace other scarce metals in the long term.

This research project was devised by the research group recently set up by Katalin Barta, which focuses on green chemistry and sustainable catalysis. The main research line concerns the conversion of biomass into high-grade chemical building blocks and fuels. Lead author of the article in Nature Communications, Tao Yan, has a Master’s degree from the University of Rennes and has been working as a PhD candidate in Barta’s group since September 2013.

Reference: Tao Yan, Ben L. Feringa, Katalin Barta, Stratingh Institute of Chemistry, University of Groningen; Iron catalysed direct alkylation of amines with alcohols. Nature Communications, November 26, 2014

Last modified:10 June 2015 2.56 p.m.
printView this page in: Nederlands

More news

  • 11 July 2019

    Major companies’ annual reports too vague about climate impact

    Many major Dutch companies publish extensive information about climate impact in their annual reports. However, very few companies provide concrete, detailed information about their own CO2 emissions, the impact of climate change on their business...

  • 08 July 2019

    UG permanently closes Yantai project

    The University of Groningen (UG) has permanently closed the project aimed at creating a branch campus in Yantai. Discussions were held with China Agricultural University, the city of Yantai and the Province of Shandong.

  • 03 July 2019

    Cheap train tickets boost public transport use but reduce customer satisfaction

    Offers of cheap single train tickets through retailers such as Kruidvat or Etos have a positive impact on the number of kilometres travelled by rail. This impact is much bigger than that of more general TV, newspaper or magazine advertising. However,...