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Research Zernike (ZIAM) News Colloquia

Zernike Institute for Advanced Materials Colloquium William M. Shih

When:Th 06-06-2013 at 16:00

Speaker: prof.dr. William M. Shih
Affiliation: Dana-Farber Cancer Institute, Department of Cancer Biology, 44 Binney St., Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering at Harvard, 3 Blackfan Circle, CLSB 5th Floor, Boston, MA 02115, USA
Title: DNA nanostructures as building blocks for molecular biophysics and future therapeutics
Date: Thursday Jun 6, 2013
Start: 16:00
Location: FSE-Building 5111.0080


Our group previously solved a key challenge for nanotechnology: programmable self-assembly of complex, three-dimensional nanostructures. Our solution was to build custom three-dimensional structures that can be conceived as stacks of nearly flat layers of DNA. I will discuss applications of this technology for molecular biophysics and therapeutics: (1) weak-alignment media for NMR structure determination of membrane proteins such as UCP2, a 30 kDa six-transmembrane helix mitochondrial proton transporter; (2) scaffolds for determining the number of SNARE complexes required for lipid-bilayer fusion; (3) how shape and size of DNA nanoparticles affects the rate of cellular internalization.