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Research Zernike (ZIAM) Macromolecular Chemistry and New Polymeric Materials Loos Group

Zernike Colloquium - Stephen Mann : Towards synthetic cellularity via protocell design and construction

When:Th 01-10-2015 15:00 - 16:00
Where:Lecture Hall: 5111.0080

Stephen Mann

Centre for Protolife Research

Centre for Organized Matter Chemistry

School of Chemistry

University of Bristol

Bristol, UK

The design and construction of compartmentalized chemical ensembles for modelling complex biological systems, exploring the origin of life, and advancing future living technologies is attracting considerable interest in a wide range of research communities.

In this talk, I will review some recent experiments undertaken in my laboratory that provide steps towards synthetic cellularity using bioinspiredchemistry principles and techniques.

I will discuss four new protocell models based on;

(i) nanoparticle self-assembly (colloidosomes),

(ii) interfacial assembly of protein-polymer nanoconjugates (proteinosomes),

(iii) micro-droplet formation (coacervation), and hybrids of the above.

I will use these new model systems to discuss pathways towards chemical cognition, modulated reactivity and basic cellularity in compartmentalized artificial micro-ensembles.