Physics Colloquium, Andrey Solov'yov, MBN, Frankfurt

Abstract:

The Multi-Scale Approach (MSA) to the molecular level quantitative assessment of radiation damage in biological targets consequent to their irradiation by ions and its implications to the ion-beam cancer therapy will be overviewed and its perspective will be discussed. The MSA approach was developed [1,2] to quantify the physical, chemical, and biological effects that take place when ion beams interact with biological targets.

Over the decade, the MSA has addressed a number of effects starting with ion propagation in tissue, features of the depth-dose profile with a Bragg peak, production of secondary electrons as a result of ionization of tissue, transport and energy loss by the secondary electrons along with other reactive species, the radial dose distribution around ion tracks, formation of wave fronts and consequent propagation of cylindrical shock waves around the ions’ paths, etc, etc [1-5]. On the other side, the nanoscopic models of radiation damage as a result of action of secondary electrons, other reactive species, or stresses due to ion induced shock waves were explored. Recently, it has become possible to join whole multiscale scenario within a single MSA capable calculating the cell survival probabilities [1]. This recipe has been tested on plasmid DNA and most recently on a number of cell lines [2,6]. A number of DNA lesions have been analysed and a criterion for lethal damage of a cell has been suggested and tested. A variety of experimental and related theoretical results such as probabilities of plasmid DNA lesions, enzyme repair foci, cell survival curves, oxygen enhancement ratios, effects of radiosensitising nanoparticles, radiation chemistry outcomes, high dose effects, etc., have become the field for either advancing the MSA or testing its predictions [2,7]. These challenges will be presented in the talk.

The phenomenon-based MSA is a unique method in its inclusiveness, versatility, and integrity with the high potential to becoming practical for clinical planning of proton and ion-beam therapy [2,8]. MBN Explorer and MBN Studio software form a solid platform for this development [9].

References

[1] E. Surdutovich, A.V. Solov’yov, Multiscale approach to the physics of radiation damage with ions (Colloquium paper), Eur. Phys. J. D, 68, 353 (2014); E. Surdutovich and A.V. Solov'yov, Multiscale modeling for cancer radiotherapies, Cancer Nanotechnology, vol. 10, 6 (2019)

[2] A.V. Solov’yov (ed.), Nanoscale insights into ion-beam cancer therapy, Springer International Publishing , Cham, Switzerland (2017), ISBN: 978-3-319-43028-7; 978-3-319-43030-0

[3] E. Surdutovich, A. Yakubovich, A.V. Solov’yov, Nature Sci. Rep. 3 , 1289 (2013).

[4] P. de Vera, R. Garcia-Molina, I. Abril, A.V. Solov’yov, Phys. Rev. Lett. 110,148104 (2013)

[ 5 ] E. Surdutovich, A. V. Solov’yov, Eur. Phys. J. D 69, 193 (2015)

[ 6 ] A.V. Verkhovtsev, E. Surdutovich and A. V. Solov’yov, Nature Sci. Rep. 6, 27654 (2016); A. Verkhovtsev, E. Surdutovich, and A.V. Solov'yov, Phenomenon-based evaluation of relative biological effectiveness of ion beams by means of the multiscale approach, Cancer Nanotechnology, vol. 10, 4 (2019)

[7] A.V. Verkhovtsev, S. McKinnon, P. de Vera, E. Surdutovich, S. Guatelli, A.V. Korol, A. Rosenfeld, A.V. Solov'yov, EPJD 69 (2015) 116; A.V. Verkhovtsev, A.V. Korol, A.V. Solov'yov, J. Phys. Chem. C 119 (2015) 11000; A.V. Verkhovtsev, A.V. Korol, A.V. Solov'yov, PRL 114 (2015) 063401; K. Haume, S. Rosa, S. Grellet, M.A. Śmiałek, K.T. Butterworth, A.V. Solov’yov, K.M. Prise, J. Golding, N.J. Mason, Nanotechnol. 7 (2016) 8; P. de Vera, N.J. Mason, F.J. Currell, A.V. Solov’yov, EPJD 70 (2016) 183; K. Haume, N.J. Mason, A.V.Solov’yov, EPJD 70 (2016) 181; E.Surdutovich, A.Verkhovtsev, A.V. Solov’yov, EPJD 71 (2017) 285; P.de Vera, E. Surdutovich, N.J. Mason, A.V. Solov’yov, EPJD 71 (2017) 281

[8] E. Surdutovich and A.V. Solov'yov, Eur. Phys. J. D, vol. 71, 210 (2017)

[9] I.A. Solov'yov, A.V. Korol, A.V. Solov'yov, Multiscale Modeling of Complex Molecular Structure and Dynamics with MBN Explorer, Springer International Publishing, Cham, Switzerland (2017)