Drug discovery is a challenging undertaking. In a context where the pharmaceutical industry finds it increasingly difficult to develop new drugs, efficient access to novel molecular scaffolds is urgently needed. Dr. Anna Hirsch has been awarded a NWO Vidi grant to use dynamic combinatorial chemistry (DCC) in combination with fragment-based drug design, (de novo) structure-based drug design (SBDD) and multicomponent reactions to accelerate the drug-discovery process. Taken together, this research will further our knowledge of the molecular basis of DCC applied to targets of biomedical interest, lead to novel molecular scaffolds, interaction modes, bio-active compounds and ways to efficiently initiate the drug discovery process. The impact of this research extends to the health and well-being of society.
Dr. Edwin Otten has been awarded a NWO Vidi grant to develop new catalysts based on earth-abundant, inexpensive elements. In order to replace the precious metal catalysts that are currently in use, this project will develop a new strategy to mimic the reactivity of these metals. The prevalence of catalysts based on precious metals is due to their versatile electronic properties that allow redox-reactions in 2-electron steps, which are key to many important chemical transformations. This type of reactivity is generally not accessible to other (non-precious) elements. By making use of organic ligands that can participate in redox-reactions, the aim of this research is to replicate the catalytic properties of precious metals to non-scarce elements.
Last week, Ben Feringa and Anouk Lubbe presented the first copy of their book Alledaagse Moleculen (Everyday Molecules) to minister Robbert Dijkgraaf. The richly illustrated book offers an accessible overview of 180 substances in our daily lives....
Dr Annette Scheepstra of the UG Arctic Centre, part of the Faculty of Arts, is about to conduct research into tourism in Antarctica and how tourists can become Antarctic ambassadors. She has been granted €1 million in funding by the Dutch Research...
The Royal Netherlands Academy of Arts and Sciences (KNAW) has appointed Professor Maria Loi and Professor Dirk Slotboom from the Faculty of Science and Engineering as members of the Academy.
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