Publicaties 2010

van Midwoud PM, Groothuis GMM, Merema MT, Verpoorte E. Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies. Biotechnology and Bioengineering, 2010; 105(1):184-194.
Notes: Supplementary information in Related Links: Comsol simulation of flow profiles in PDMS chip with and without PC filter. DOI

Ásgeirsdóttir SA, Talman EG, de Graaf IAM, Kamps JAAM, Satchell SC, Mathieson PW, Ruiters MHJ, Molema G. Targetd transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro – A quantitative study. Journal of Controlled Release, 2010; 141(2):241-251. DOI

Prakash J, Beljaars L, Harapanahalli AK, Zeinstra-Smith M, de Jager-Krikken A, Hessing M, Steen H, Poelstra K. Tumor-targeted intracellular delivery of anticancer drugs through the mannose-6-phosphate/insulin-like growth factor II receptor. International Journal of Cancer, 2010, DOI

Khan AA, Dragt BS, Groothuis GMM. Regulation of VDR expression in rat and human intestine and liver - Consequences for CYP3A expression. Toxicology in Vitro, 2010, DOI

Chow ECY, Sun H, Khan AA, Groothuis GMM, Pang KS. Effects of 1a ,25-dihydroxyvitamin D(3) on transporters and enzymes of the rat intestine and kidney in vivo. Biopharmaceutics & drug Disposition, 2010; 31(1):91-108. DOI

Alffenaar J-WC, Kosterink JGW, van Altena R, van der Werf TS, Uges DRA, Proost JH. Limited sampling strategies for therapeutic drug monitoring of linezolid in patients with multidrug-resistant tuberculosis. Therapeutic Drug Monitoring, 2010; 32(1):97-101. DOI

Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaar s L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K, Brenner DA, Ginès P, Bataller R. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology, 2010, DOI

Poelstra K, Dijkstra G, Tuin A. Authors' response. Gut, 2010; 59(4):560. DOI
Notes: Authors' response on the letters: "It may not be intestinal, but tissue non-specific alkaline phosphatase" by O. Martínez-Augustin, R. López-Posadas, R. González, I. Ballester, M. Dolores Suárez, A. Zarzuelo and F. Sánchez de Medina, in Gut 2010 ;59(4):560, comment on the article: "Role of alkaline phosphatase in colitis in man and rats" by A. Tuin, K. Poelstra, A. de Jager-Krikken, L. Bok, W. Raaben, M.P. Velders and G. Dijkstra, in Gut 2009 ;58(3):379-387. DOI

Prakash J, de Jong E, Post E, Gouw ASH, Beljaars L, Poelstra K. A novel approach to deliver anticancer drugs to key cell types in tumors using a PDGF receptor-binding cyclic peptide containing carrier. Journal of Controlled Release, 2010;1-16. DOI

Poelstra K, Greupink R, Beljaars L. Targeting fibrosis with selective drug carriers. Arab Journal of Gastroenterology, 2010; 10(4, Supplement 1):S27-S29. Keyword: Review DOI

Schaffert CS, Duryee MJ, Bennett RG, DeVeney AL, Tuma DJ, Olinga P, Easterling KC, Thiele GM, Klassen LW. Exposure of precision-cut rat liver slices (PCLS) to ethanol accelerates fibrogenesis. American Journal of Physiology Gastrointestinal and Liver Physiology, 2010.
DOI

Heeremans EH, Proost JH, Eleveld DJ, Absalom AR, Struys MMRF. Population pharmacokinetics and pharmacodynamics in anesthesia, intensive care and pain medicine. Current Opinion in Anaesthesiology, 2010; 23(4):479-484. DOI
Notes: Research Group Department of Anesthesiology

Roskott AM, Nieuwenhuijs VB, Leuvenink HGD, Dijkstra G, Ottens P, de Jager MH, Gonalves Dias Pereira P, Fidler V, Groothuis GMM, Ploeg RJ, de Graaf IAM. Reduced ischemia-reoxygenation injury in rat intestine after luminal preservation with a tailored solution. Transplantation , 2010; 90(6):622-629. DOI

de Graaf IAM, Olinga P, de Jager MH, Merema MT, de Kanter R, van de Kerkhof EG, Groothuis GMM. Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies. Nature Protocols, 2010; 5(9):1540-1551. DOI

van Midwoud PM, Merema MT, Verpoorte E, Groothuis GMM. A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices. Lab on a Chip, 2010.  DOI

Chen KT, Malo MS, Beasley-Topliffe LK, Poelstra K, Millan JL, Mostafa G, Alam SN, Ramasamy S, Warren HS, Hohmann EL, Hodin RA. A role for intestinal alkaline phosphatase in the maintenance of local gut immunity. Digestive Diseases and Sciences, 2010.  DOI

Khan AA, Chow ECY, Porte RJ, Pang KS, Groothuis GMM. The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices. Toxicology in Vitro, 2010. DOI