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University Medical Center Groningen

New key publication:Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion.

04 November 2016
Transintestinal Cholesterol Transport
Transintestinal Cholesterol Transport

Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion

Highlights

  • Cholesterol is excreted in humans via biliary and direct transintestinal secretion
  • In humans, TICE accounts for 35% of fecal cholesterol excretion
  • Ezetimibe increases fecal cholesterol excretion primarily by activation of TICE
  • The cholesterol transporter ABCG5/G8 mediates most of the TICE flux

Cell Metabolism

Editorial: Of TICE in Men .

Last modified:13 January 2017 07.30 a.m.

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