
The New Key Publication of Lianmin Chen: Cover story of Cell Reports, October 6, 2020

On the cover: Bile acids are implicated in the etiology of obesity-related conditions such as non-alcoholic fatty liver disease. In this issue, Chen et al. use an integrative multi-omics approach to highlight the remarkable inter-individual variations of plasma and fecal bile acid profiles within humans with obesity and their linkages with genetic background, the gut microbiome, liver fat content, and circulating lipids. Pictured is a rainbow image of individual bile acid profiles. Image by Lianmin Chen.
Bile acids have been implicated in the etiology of obesity-related conditions in humans, such as insulin resistance, hyperlipidemia, NAFLD and NASH, via FXR and TGR5 signaling. Differently structured primary and secondary human bile acids exert variable signaling activities. In this systematic study, Chen et al. define genetic and microbial associations to plasma and fecal bile acid concentrations and composition in obese humans and establish their relationships to liver fat content and lipid phenotypes
BY:
- Lianmin Chen
- Inge C. L. van den Munckhof
- Kiki Schraa
- Rob ter Horst
- Martijn Koehorst
- Martijn van Faassen
- Claude van der Ley
- Marwah Doestzada
- Daria V. Zhernakova
- Alexander Kurilshikov
- Vincent W. Bloks
- Albert K. Groen
- Human Functional Genomics Project, Niels P. Riksen
- Joost H. W. Rutten
- Leo A. B. Joosten
- Cisca WijmengaAl
- exandra Zhernakova
- Mihai G. Netea
- Jingyuan Fu
- Folkert Kuipers
Last modified: | 06 October 2020 5.01 p.m. |
More news
-
14 February 2023
Lift to the inclusive workplace
There is plenty of work, and yet people with a disability are still often sidelined. One plus one is two, or so you’d think: this is the perfect time to help this group of workers find a job. The intention is there, also within the University, but...
-
15 December 2022
Groningen contributes to major research initiative into energy-efficient information technology
The Dutch science funding agency NWO recently awarded a large research project into new concepts for energy-efficient information technology of no less than ten million euros
-
05 December 2022
Frans J. Sijtsma new Director Agricola School
On the recommendation of the Board of the University of Groningen, Dr Frans J. Sijtsma has been appointed as academic director of the Rudolf Agricola School for Sustainable Development with effect from 1 February 2023. This concerns a 0.5 FTE...