Preview Cell Metabolism – not all is bad about lithocholic acid

Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification

Folkert Kuipers, Jan Freark de Boer, Bart Staels

The microbiome is well known to influence the immune response of the host. Song et al. now show that the microbiome modulates adaptive immunity in mice through formation of bile acid species acting on RORγ ⁺ regulatory T cells via the Vitamin D Receptor, thereby lowering the vulnerability for chemically induced colitis.

https://doi.org/10.1016/j.cmet.2020.02.006

Free access (April 22,2020): https://authors.elsevier.com/a/1agGV5WXUlIcPm