New pathway of macrophage cholesterol efflux - Commentary in PNAS
- Marit Westerterp and Alan R. Tall
Macrophage foam cells (i.e., cholesteryl ester-laden macrophages) are abundant in atherosclerotic plaques, and increased macrophage foam cell content is associated with plaque instability. Macrophages are generally thought to unload surplus cholesterol via efflux mediated by the ATP-binding cassette transporters A1 and G1 (ABCA1 and ABCG1) to apolipoprotein A1 and high-density lipoproteins HDLs, respectively. Several studies in large-population cohorts have shown that the cholesterol efflux capacity of HDL (i.e., its potential to act as an acceptor for cholesterol efflux from macrophages) is an inverse predictor of cardiovascular disease , highlighting the importance of cholesterol efflux as an atheroprotective mechanism.
More : https://www.pnas.org/content/early/2020/05/15/2007836117
| Last modified: | 20 May 2020 1.22 p.m. |
More news
-
14 February 2023
Lift to the inclusive workplace
There is plenty of work, and yet people with a disability are still often sidelined. One plus one is two, or so you’d think: this is the perfect time to help this group of workers find a job. The intention is there, also within the University, but...
-
15 December 2022
Groningen contributes to major research initiative into energy-efficient information technology
The Dutch science funding agency NWO recently awarded a large research project into new concepts for energy-efficient information technology of no less than ten million euros
-
05 December 2022
Frans J. Sijtsma new Director Agricola School
On the recommendation of the Board of the University of Groningen, Dr Frans J. Sijtsma has been appointed as academic director of the Rudolf Agricola School for Sustainable Development with effect from 1 February 2023. This concerns a 0.5 FTE...