Macrophage foam cells (i.e., cholesteryl ester-laden macrophages) are abundant in atherosclerotic plaques, and increased macrophage foam cell content is associated with plaque instability. Macrophages are generally thought to unload surplus cholesterol via efflux mediated by the ATP-binding cassette transporters A1 and G1 (ABCA1 and ABCG1) to apolipoprotein A1 and high-density lipoproteins HDLs, respectively. Several studies in large-population cohorts have shown that the cholesterol efflux capacity of HDL (i.e., its potential to act as an acceptor for cholesterol efflux from macrophages) is an inverse predictor of cardiovascular disease , highlighting the importance of cholesterol efflux as an atheroprotective mechanism.
More : https://www.pnas.org/content/early/2020/05/15/2007836117
Two professors nominated by the University of Groningen have been awarded Royal Decorations on Tuesday 26 April. Professor K.U. Loos is appointed Knight of the Order of the Netherlands Lion. She received this honour from Mayor K. Schuiling at...
Cisca Wijmenga treedt per 1 september 2023 toe tot de Raad van Toezicht van de Hanzehogeschool.
The Board of the University of Groningen has taken note of the Letter to the House of Representatives regarding internationalization in higher education, sent to the House on Friday 21 April by the Minister of Education, Culture and Science Robbert...
The UG website uses functional and anonymous analytics cookies. Please answer the question of whether or not you want to accept other cookies (such as tracking cookies).
If no choice is made, only basic cookies will be stored. More information