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University Medical Center Groningen

New key publication: Individual variations in cardiovascular -disease- related protein levels are driven by genetics and gut microbiome

24 September 2018

Despite a growing body of evidence, the role of the gut microbiome in cardiovascular diseases is still unclear. Here, we present a systems-genome-wide and metagenome-wide association study on plasma concentrations of 92 cardiovascular-disease-related proteins in the population cohort LifeLines-DEEP.

We identified genetic components for 73 proteins and microbial associations for 41 proteins, of which 31 were associated to both. The genetic and microbial factors identified mostly exert additive effects and collectively explain up to 76.6% of inter-individual variation (17.5% on average). Genetics contribute most to concentrations of immune-related proteins, while the gut microbiome contributes most to proteins involved in metabolism and intestinal health.

We found several host–microbe interactions that impact proteins involved in epithelial function, lipid metabolism, and central nervous system function.

This study provides important evidence for a joint genetic and microbial effect in cardiovascular disease and provides directions for future applications in personalized medicine

Link to Nature Genetics:

UMCG/RUG-persbericht: Wisselwerking tussen genen en darmbacteriën belangrijk voor risico op hart- en vaatziekten

Hart- en vaatziekten komen veel voor, maar over de oorzaken is nog veel onduidelijk. Genetische gevoeligheid speelt een rol, maar ook darmbacteriën kunnen bijdragen aan het risico. In een nieuw onderzoek laten onderzoekers van het Universitair Medisch Centrum Groningen nu voor het eerst zien dat de wisselwerking tussen genen en darmbacteriën belangrijk is voor het ontstaan van hart- en vaatziekten. Deze ontdekking kan in de toekomst leiden tot gepersonaliseerde behandelingen. De resultaten van het onderzoek zijn op 24 september gepubliceerd in het tijdschrift Nature Genetics​.

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Last modified:25 September 2018 09.40 a.m.

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