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Research Pediatrics
University Medical Center Groningen

New Key Publication: Treatment of intestinal and liver features in cystic fibrosis mice by the osmotic laxative polyethylene glycol

28 September 2023
Graphical Abstract
Graphical Abstract


  • Anna Bertolini
  • Vincent W. Bloks
  • Marijn Wilmink
  • Eline Bos
  • Ivo van de Peppel
  • Roos Eilers
  • Sake Prins
  • Rachel Thomas
  • Alain de Bruin
  • Henkjan Verkade
  • Johan W. Jonker


  • Cystic fibrosis (CF) features bile acids, fat, and cholesterol malabsorption
  • Malabsorption is associated with decreased intestinal nuclear receptor signaling
  • The laxative PEG increased bile acids, fat, and cholesterol absorption in CF mice
  • Concomitantly, PEG improved intestinal nuclear receptor signaling in CF mice
  • PEG decreased hepatic inflammation and cholesterol synthesis in CF mice

Read more: Journal of Cystic Fibrosis:

Last modified:28 September 2023 11.23 a.m.

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