New Key Publication: Treatment of intestinal and liver features in cystic fibrosis mice by the osmotic laxative polyethylene glycol
Authors:
- Anna Bertolini
- Vincent W. Bloks
- Marijn Wilmink
- Eline Bos
- Ivo van de Peppel
- Roos Eilers
- Sake Prins
- Rachel Thomas
- Alain de Bruin
- Henkjan Verkade
- Johan W. Jonker
Highlights
- Cystic fibrosis (CF) features bile acids, fat, and cholesterol malabsorption
- Malabsorption is associated with decreased intestinal nuclear receptor signaling
- The laxative PEG increased bile acids, fat, and cholesterol absorption in CF mice
- Concomitantly, PEG improved intestinal nuclear receptor signaling in CF mice
- PEG decreased hepatic inflammation and cholesterol synthesis in CF mice
Read more: Journal of Cystic Fibrosis: https://www.sciencedirect.com/science/article/pii/S1569199323009190
| Last modified: | 28 September 2023 11.23 a.m. |
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