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Research Pediatrics
University Medical Center Groningen

New Key Publication: The chemotherapeutic drug doxorubicin does not exacerbate p16Ink4a-positive senescent cell accumulation and cardiometabolic disease development in young adult female LDLR-deficient mice

24 April 2023


  • Doxorubicin treatment induces acute gonadal white adipose tissue inflammation.
  • DOX does not induce p16Ink4a+-senescent cells in young adult female Ldlr−/−-p16-3MR mice.
  • DOX treatment results in a long-term reduction in gonadal white adipose tissue mass.
  • Long-term cardiometabolic health in young adult female HFC-diet-fed mice is not affected by DOX.
  • Clearance of p16Ink4a+-senescent cells does not improve diet-induced atherosclerosis.


  • Andrea C Postmus
  • Janine K Kruit
  • Roos E Eilers
  • Rick Havinga
  • Mirjam H Koster
  • Yoshikazu Johmura
  • Makoto Nakanishi
  • Bart van de Sluis
  • Johan W Jonker

Read more: Toxicology and Applied Pharmacology:

Last modified:24 April 2023 10.05 a.m.

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