New Key Publication: The chemotherapeutic drug doxorubicin does not exacerbate p16Ink4a-positive senescent cell accumulation and cardiometabolic disease development in young adult female LDLR-deficient mice
Highlights
- Doxorubicin treatment induces acute gonadal white adipose tissue inflammation.
- DOX does not induce p16Ink4a+-senescent cells in young adult female Ldlr−/−-p16-3MR mice.
- DOX treatment results in a long-term reduction in gonadal white adipose tissue mass.
- Long-term cardiometabolic health in young adult female HFC-diet-fed mice is not affected by DOX.
- Clearance of p16Ink4a+-senescent cells does not improve diet-induced atherosclerosis.
Authors:
- Andrea C Postmus
- Janine K Kruit
- Roos E Eilers
- Rick Havinga
- Mirjam H Koster
- Yoshikazu Johmura
- Makoto Nakanishi
- Bart van de Sluis
- Johan W Jonker
Read more: Toxicology and Applied Pharmacology: https://www.sciencedirect.com/science/article/pii/S0041008X23001709?via%3Dihub
| Last modified: | 24 April 2023 10.05 a.m. |
More news
-
06 June 2025
India-Netherlands Hydrogen Valley Fellowship Programme announced
To coincide with World Environment Day, 5 June 2025, the Indian Department of Science and Technology and the University of Groningen yesterday announced a Hydrogen Valley Fellowship Programme Partnership, allowing talented Indian scholars working on...
-
24 March 2025
UG 28th in World's Most International Universities 2025 rankings
The University of Groningen has been ranked 28th in the World's Most International Universities 2025 by Times Higher Education. With this, the UG leaves behind institutions such as MIT and Harvard. The 28th place marks an increase of five places: in...
-
05 March 2025
Women in Science
The UG celebrates International Women’s Day with a special photo series: Women in Science.