New Key Publication: The chemotherapeutic drug doxorubicin does not exacerbate p16Ink4a-positive senescent cell accumulation and cardiometabolic disease development in young adult female LDLR-deficient mice

Highlights

• Doxorubicin treatment induces acute gonadal white adipose tissue inflammation.
• DOX does not induce p16^Ink4a+-senescent cells in young adult female Ldlr^−/−-p16-3MR mice.
• DOX treatment results in a long-term reduction in gonadal white adipose tissue mass.
• Long-term cardiometabolic health in young adult female HFC-diet-fed mice is not affected by DOX.
• Clearance of p16^Ink4a+-senescent cells does not improve diet-induced atherosclerosis.

Authors:

• Andrea C Postmus
• Janine K Kruit
• Roos E Eilers
• Rick Havinga
• Mirjam H Koster
• Yoshikazu Johmura
• Makoto Nakanishi
• Bart van de Sluis
• Johan W Jonker

Read more: Toxicology and Applied Pharmacology: https://www.sciencedirect.com/science/article/pii/S0041008X23001709?via%3Dihub