New Key Publication: Role of bile acid receptor FXR in development and function of brown adipose tissue
17 November 2022
Highlights
- FXR is expressed in brown adipose tissue in mice and suppressed by cold.
- Mild adipose-specific overexpression of FXR causes whitening and fibrosis in brown adipose tissue.
- FXR hampers brown adipose tissue development and function.
- A humanized bile acid profile exacerbates brown adipose whitening in mice and suppresses Ucp1 and Dio2.
- FXR modulates BAT function and morphology at the level of tissue maintenance and development. FXR seems to act opposite and upstream to TGR5.
Authors:
- J.Yang
- H.D.de Vries
- A.Mayeuf-Louchart
- J.H.Stroeve
- V.W.Bloks
- M.Koehorst
- H.Duez
- B.Staels
- F.Kuipers
- T.van Zutphen
Read more: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids: https://www.sciencedirect.com/science/article/pii/S1388198122001470
| Last modified: | 17 November 2022 10.14 a.m. |
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