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University Medical Center Groningen

New Key Publication: Role of bile acid receptor FXR in development and function of brown adipose tissue

17 November 2022
Fxr BAT
Fxr BAT

Highlights

  • FXR is expressed in brown adipose tissue in mice and suppressed by cold.
  • Mild adipose-specific overexpression of FXR causes whitening and fibrosis in brown adipose tissue.
  • FXR hampers brown adipose tissue development and function.
  • A humanized bile acid profile exacerbates brown adipose whitening in mice and suppresses Ucp1 and Dio2.

  • FXR modulates BAT function and morphology at the level of tissue maintenance and development. FXR seems to act opposite and upstream to TGR5.

Authors:

  • J.Yang
  • H.D.de Vries
  • A.Mayeuf-Louchart
  • J.H.Stroeve
  • V.W.Bloks
  • M.Koehorst
  • H.Duez
  • B.Staels
  • F.Kuipers
  • T.van Zutphen

Read more: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids: https://www.sciencedirect.com/science/article/pii/S1388198122001470

Last modified:17 November 2022 10.14 a.m.

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