Small molecule inhibitors directed against the RAS-MAPK pathway are used to treat various malignancies, but side effects can result in treatment interruption, morbidity, and mortality. We show that short-term MEK inhibition deregulates the expression of genes involved in bile acid metabolism and consequently causes profound alterations in bile acid metabolism. Our work contributes to understanding the initial mechanisms by which RAS MAPK inhibitors can cause gastrointestinal complications, hepatotoxicity, and related side effects.
Read more: Biomedicine & Pharmacotherapy: https://www.sciencedirect.com/science/article/pii/S0753332223000586
The Dutch science funding agency NWO recently awarded a large research project into new concepts for energy-efficient information technology of no less than ten million euros
On the recommendation of the Board of the University of Groningen, Dr Frans J. Sijtsma has been appointed as academic director of the Rudolf Agricola School for Sustainable Development with effect from 1 February 2023. This concerns a 0.5 FTE...
Science shops. What kinds of things can you buy there? A knowledge sandwich? A wisdom smoothie? Bacteria on demand? It is not clear to everyone what science shops have to offer. And yet, they play an important role for society, researchers, and...
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