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Research Pediatrics
University Medical Center Groningen

New Key Publication: Large HDL particles negatively associate with leukocyte counts independent of cholesterol efflux capacity: A cross sectional study in the population-based LifeLines DEEP cohort

18 January 2022
Large HDL
Large HDL

Background and aims

Leukocytosis, the expansion of white blood cells, is associated with increased cardiovascular risk. Studies in animal models have shown that high-density lipoprotein cholesterol (HDL-c) suppresses leukocytosis by mediating cholesterol efflux from hematopoietic stem and progenitor cells. HDL-c showed a moderate negative association with leukocyte numbers in the UK Biobank and Multi-Ethnic Study of Atherosclerosis. Cholesterol efflux capacity of HDL (HDL-CEC) or HDL particle (HDL-P) number have been proposed as improved inverse predictors of CVD compared to plasma HDL-c. In the LifeLines DEEP (LLD) cohort (n = 962), a sub-cohort representing the prospective population-based LL cohort from the North of The Netherlands, we tested the hypothesis that HDL-CEC and HDL-P were associated with lower leukocyte counts.


  • Anouk G. Groenen
  • Venetia Bazioti
  • Isabelle A. van Zeventer
  • Lianmin Chen
  • Hilde E. Groot
  • Jan-Willem Balder
  • Alexandra Zhernakova
  • Pim van der Harst
  • Antoine Rimbert
  • Jan Albert Kuivenhoven
  • Jingyuan Fu
  • Marit Westerterp

Link to the Paper:

Last modified:18 January 2022 09.55 a.m.

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