New Key Publication: Large HDL particles negatively associate with leukocyte counts independent of cholesterol efflux capacity: A cross sectional study in the population-based LifeLines DEEP cohort
Background and aims
Leukocytosis, the expansion of white blood cells, is associated with increased cardiovascular risk. Studies in animal models have shown that high-density lipoprotein cholesterol (HDL-c) suppresses leukocytosis by mediating cholesterol efflux from hematopoietic stem and progenitor cells. HDL-c showed a moderate negative association with leukocyte numbers in the UK Biobank and Multi-Ethnic Study of Atherosclerosis. Cholesterol efflux capacity of HDL (HDL-CEC) or HDL particle (HDL-P) number have been proposed as improved inverse predictors of CVD compared to plasma HDL-c. In the LifeLines DEEP (LLD) cohort (n = 962), a sub-cohort representing the prospective population-based LL cohort from the North of The Netherlands, we tested the hypothesis that HDL-CEC and HDL-P were associated with lower leukocyte counts.
Authors:
- Anouk G. Groenen
- Venetia Bazioti
- Isabelle A. van Zeventer
- Lianmin Chen
- Hilde E. Groot
- Jan-Willem Balder
- Alexandra Zhernakova
- Pim van der Harst
- Antoine Rimbert
- Jan Albert Kuivenhoven
- Jingyuan Fu
- Marit Westerterp
Link to the Paper: https://doi.org/10.1016/j.atherosclerosis.2022.01.008
Last modified: | 18 January 2022 09.55 a.m. |
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