New key Publication: High childhood serum triglyceride concentrations associate with hepatocellular adenoma development in patients with glycogen storage disease type Ia
Glycogen storage disease type Ia (GSDIa) is an inborn error of carbohydrate metabolism caused by pathogenic variants in the G6PC1 gene, and is associated with hepatocellular adenoma (HCA) formation. Data on risk factors for HCA occurrence in GSDIa are scarce. We investigated HCA development in relation to sex, G6PC1 genotype, and serum triglyceride concentration (TG).
Highlights
- Glycogen storage disease Ia (GSDIa) is a metabolic disease caused by G6PC1 mutation
- GSDIa patients often form hepatocellular adenoma (HCA), with unclear risk factors
- Metabolic control in GSDIa is commonly evaluated through serum triglycerides (TG)
- GSDIa patients with high childhood TG had increased risk and earlier onset of HCA
- Sex-associated hypertriglyceridemia and G6PC1 genotype were not associated with HCA
Authors:
- Martijn P.D. Haring
- Fabian Peeks
- Maaike H. Oosterveer
- Martijn C.G.J. Brouwers
- Carla E.M. Hollak
- Mirian C.H. Janssen
- Janneke G. Langendonk
- Alexander J.M. Rennings
- Margreet A.E.M. Wagenmakers
- Henkjan J. Verkade
- Terry G.J. Derks
- Vincent E. de Meijer
Read more: https://www.jhep-reports.eu/article/S2589-5559(22)00084-2/fulltext
Last modified: | 21 June 2022 7.01 p.m. |
More news
-
16 April 2024
UG signs Barcelona Declaration on Open Research Information
In a significant stride toward advancing responsible research assessment and open science, the University of Groningen has officially signed the Barcelona Declaration on Open Research Information.
-
02 April 2024
Flying on wood dust
Every two weeks, UG Makers puts the spotlight on a researcher who has created something tangible, ranging from homemade measuring equipment for academic research to small or larger products that can change our daily lives. That is how UG...
-
18 March 2024
VentureLab North helps researchers to develop succesful startups
It has happened to many researchers. While working, you suddenly ask yourself: would this not be incredibly useful for people outside of my own research discipline? There are many ways to share the results of your research. For example, think of a...