New key Publication: High childhood serum triglyceride concentrations associate with hepatocellular adenoma development in patients with glycogen storage disease type Ia
Glycogen storage disease type Ia (GSDIa) is an inborn error of carbohydrate metabolism caused by pathogenic variants in the G6PC1 gene, and is associated with hepatocellular adenoma (HCA) formation. Data on risk factors for HCA occurrence in GSDIa are scarce. We investigated HCA development in relation to sex, G6PC1 genotype, and serum triglyceride concentration (TG).
Highlights
- Glycogen storage disease Ia (GSDIa) is a metabolic disease caused by G6PC1 mutation
- GSDIa patients often form hepatocellular adenoma (HCA), with unclear risk factors
- Metabolic control in GSDIa is commonly evaluated through serum triglycerides (TG)
- GSDIa patients with high childhood TG had increased risk and earlier onset of HCA
- Sex-associated hypertriglyceridemia and G6PC1 genotype were not associated with HCA
Authors:
- Martijn P.D. Haring
- Fabian Peeks
- Maaike H. Oosterveer
- Martijn C.G.J. Brouwers
- Carla E.M. Hollak
- Mirian C.H. Janssen
- Janneke G. Langendonk
- Alexander J.M. Rennings
- Margreet A.E.M. Wagenmakers
- Henkjan J. Verkade
- Terry G.J. Derks
- Vincent E. de Meijer
Read more: https://www.jhep-reports.eu/article/S2589-5559(22)00084-2/fulltext
| Last modified: | 21 June 2022 7.01 p.m. |
More news
-
04 July 2022
Research on how tourists become Antarctic ambassadors
Dr Annette Scheepstra of the UG Arctic Centre, part of the Faculty of Arts, is about to conduct research into tourism in Antarctica and how tourists can become Antarctic ambassadors. She has been granted €1 million in funding by the Dutch Research...
-
12 May 2022
KNAW appoints two UG professors as members
The Royal Netherlands Academy of Arts and Sciences (KNAW) has appointed Professor Maria Loi and Professor Dirk Slotboom from the Faculty of Science and Engineering as members of the Academy.
-
15 March 2022
Vici grants for three UG researchers
The Dutch Research Council (NWO) has awarded three Vici grants, worth €1.5 million each, to three UG researchers. Prof. J.W Romeijn, Prof. S. Hoekstra, Prof. K.I. Caputi can use this money to develop an innovative line of research and to set up...