New Key Publication: Cholangiopathy and biliary fibrosis in Cyp2c70-deficient mice are fully reversed by ursodeoxycholic acid
Authors: J.F. de Boer, H.D. de Vries, A. Palmiotti, R. Li, M. Doestzada, J.A. Hoogerland, J. Fu, A.M. La Rose, M. Westerterp, N.L. Mulder, M.V. Hovingh, M. Koehorst, N.J. Kloosterhuis, J.C. Wolters, V.W. Bloks, J.T. Haas, D. Dombrowicz, B. Staels, B. van de Sluis, F. Kuipers
Bile acids (BAs) aid intestinal fat absorption and exert systemic actions by receptor-mediated signaling. BA receptors have been identified as drug targets for liver diseases. Yet, differences in BA metabolism between humans and mice hamper translation of pre-clinical outcomes. Cyp2c70-ablation in mice prevents synthesis of mouse/rat-specific muricholic acids (MCAs), but potential (patho)physiological consequences of their absence are unknown. We therefore assessed age- and gender-dependent effects of Cyp2c70-deficiency in mice.
| Last modified: | 11 December 2020 2.24 p.m. |
More news
-
14 February 2023
Lift to the inclusive workplace
There is plenty of work, and yet people with a disability are still often sidelined. One plus one is two, or so you’d think: this is the perfect time to help this group of workers find a job. The intention is there, also within the University, but...
-
15 December 2022
Groningen contributes to major research initiative into energy-efficient information technology
The Dutch science funding agency NWO recently awarded a large research project into new concepts for energy-efficient information technology of no less than ten million euros
-
05 December 2022
Frans J. Sijtsma new Director Agricola School
On the recommendation of the Board of the University of Groningen, Dr Frans J. Sijtsma has been appointed as academic director of the Rudolf Agricola School for Sustainable Development with effect from 1 February 2023. This concerns a 0.5 FTE...