Skip to ContentSkip to Navigation
Research Pediatrics
University Medical Center Groningen

New Key Publication: A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis

16 March 2022


  • Variation the GALNT2 gene locus is associated with adiposity and BMI.
  • GalNac-T2 plays an important and dynamic role in whole-body energy homeostasis.
  • The insulin receptor is a novel substrate of GalNAc-T2.
  • Tissue-specific models are required to dissect local roles of GalNac-T2-mediated O-linked glycosylation.

GALNT2, encoding polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2), was initially discovered as a regulator of high-density lipoprotein metabolism. GalNAc-T2 is known to exert these effects through post-translational modification, i.e., O-linked glycosylation of secreted proteins with established roles in plasma lipid metabolism. More recently it has become clear that loss of GALNT2 in rodents, cattle, nonhuman primates and humans should be regarded as a novel congenital disorder of glycosylation which affects development and body weight. The role of GALNT2 in metabolic abnormalities other than plasma lipids, including insulin sensitivity and energy homeostasis, is poorly understood. Taken together, this study identifies a novel role for GALNT2 in energy homeostasis and our findings suggest that the local effects of GalNAc-T2 are mediated through posttranslational modification of the insulin receptor.


  • Cristy R.C. Verzijl
  • Federico Oldoni
  • Natalia Loaiza
  • Justina C. Wolters
  • Antoine Rimbert
  • E. Tian
  • Weiming Yang
  • Dicky Struik
  • Marieke Smit
  • Niels J. Kloosterhuis
  • Amy J. Fernandez
  • Nadine L. Samara
  • Kelly G. Ten Hagen
  • Kruti Dalal
  • Aliona Chernish
  • Peggy McCluggage
  • Lawrence A.Tabak
  • Johan W. Jonker
  • Jan Albert Kuivenhoven

The paper in Molecular Metabolism :

Last modified:16 March 2022 4.48 p.m.

More news

  • 12 September 2023

    Art in times of AI

    Leonardo Arriagada Beltran conducted his PhD research on the interface of computer-generated art and the constantly evolving field of Artificial Intelligence (AI). He will defend his Phd thesis on 21 September. His research offers valuable insights...

  • 28 August 2023

    Harish Vedantham and Casper van der Kooi nominated for 'Wetenschapstalent 2023'

    Harish Vedantham and Casper van der Kooi have been nominated by New Scientist for Wetenschapstalent 2023 (Science Talent 2023). This election is meant to give young scientists and their research a stage.

  • 26 July 2023

    Five promising UG researchers to top institutes abroad on Rubicon grants

    No less than five promising PhD graduates from the University of Groningen will be able to conduct research at top institutes abroad for two years thanks to the Rubicon programme organized by the Netherlands Organisation for Scientific Research...