GALNT2, encoding polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2), was initially discovered as a regulator of high-density lipoprotein metabolism. GalNAc-T2 is known to exert these effects through post-translational modification, i.e., O-linked glycosylation of secreted proteins with established roles in plasma lipid metabolism. More recently it has become clear that loss of GALNT2 in rodents, cattle, nonhuman primates and humans should be regarded as a novel congenital disorder of glycosylation which affects development and body weight. The role of GALNT2 in metabolic abnormalities other than plasma lipids, including insulin sensitivity and energy homeostasis, is poorly understood. Taken together, this study identifies a novel role for GALNT2 in energy homeostasis and our findings suggest that the local effects of GalNAc-T2 are mediated through posttranslational modification of the insulin receptor.
The paper in Molecular Metabolism : https://www.sciencedirect.com/science/article/pii/S2212877822000412
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