New key publication:A liver-specific long non-coding RNA with a role in cell viability is elevated in human non-alcoholic steatohepatitis
11 January 2017
- Hepatocyte apoptosis in non-alcoholic steatohepatitis (NASH) can lead to fibrosis and cirrhosis, which permanently damage the liver. Understanding the regulation of hepatocyte apoptosis is therefore important to identify therapeutic targets that may prevent the progression of NASH to fibrosis.
- We discovered a liver-specific lncRNA (RP11-484N16.1) on chromosome 18 that showed significantly elevated expression in the liver tissue of NASH patients.
- This lncRNA, correlated with NASH grade , lobular inflammation and non-alcoholic fatty liver disease activity score
Conclusion:
- we identified a lncRNA that can play an important regulatory role in liver function and provide new insights into the regulation of hepatocyte viability in NASH.
More : Hepatology 2017
| Last modified: | 13 January 2017 07.12 a.m. |
More news
-
04 July 2025
University of Groningen awards different prizes during Ceremony of Merits
The UG awarded different prizes to excellent researchers and students during the Ceremony of Merits on 4 July 2025.
-
02 July 2025
Relinde Weil reappointed as a member of the Supervisory Board UG
The Minister of Education has reappointed Relinde Weil for a second term as a member of the Supervisory Board of the University of Groningen.
-