On the cover: The Beneficial Effects of ASBT Inactivation Depend on Dietary Fat Composition

Back Cover: Molecular Nutrition & Food Research: Vol 64, No 24

Reported by:

• Ivo P. van de Peppel
• Anuradha Rao
• Marleen B. Dommerholt
• Laura Bongiovanni
• Rachel Thomas
• Alain de Bruin
• Saul J. Karpen
• Paul A. Dawson
• Henkjan J. Verkade
• Johan W. Jonker

Inactivation of the apical sodium bile acid transporter (ASBT) interrupts the enterohepatic circulation of bile acids and subsequently impairs lipid absorption. Asbt−/− mice are protected from obesity, insulin resistance and fatty liver disease when fed a high‐fat diet rich in saturated but not polyunsaturated fatty acids, highlighting the importance of dietary composition in assessment of treatments targeting bile acid homeostasis.

Read more : https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202000750