Publications Immunology of cell transplants

Rui Cao, Efstathios Avgoustiniatos, Klearchos Papas, Paul de Vos and Jonathan R. T. Lakey. Mathematical predictions of oxygen availability in micro- and macro-encapsulated human and porcine pancreatic islets. J Biomed Mater Res. 2019 doi:10.1002/jbm.b.34393

Marinko Scremac, Ji Lei, Madeleine F.E. Pensons, Christian Schuetz, Jonathan R.T. Lakey, Klearchos K. Papas, Pushkar S. Varde, Paul de Vos, Timothy Brauns, James Markmann, Mark C. Poznansky and Bernhard Hering. Preliminary Studies of the Impact of CXCL12 on the Foreign Body Reaction to Pancreatic Islets Microencapsulated in Alginate in Nonhuman Primates. Transplantation Direct. 2019. doi:10.1097/TXD.0000000000000890

Alexandra M. Smink, Paul de Vos. Therapeutic Strategies for Modulating the Extracellular Matrix to Improve Pancreatic Islet Function and Survival After Transplantation. Current Diabetes Reports. 2018. doi.org/10.1007/s11892-018-1014-4

Alexandra M. Smink, Bart J. de Haan, Jonathan R. T. Lakey, Paul de Vos. Polymer scaffolds for pancreatic islet transplantation — Progress and challenges. Am J Transplant. 2018;00:1–7. doi.org/10.1111/ajt.14942

Rangarajan Sambathkumar, Renate Akkerman, Sumitava Dastidar, Philip Roelandt, Manoj Kumar, Manmohan Bajaj, Ana Rita Mestre Rosa, Nicky Helsen, Veerle Vanslembrouck, Eric Kalo, Satish Khurana, Jos Laureys, Conny Gysemans, Marijke M. Faas, Paul de Vos, Catherine M. Verfaillie. Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells. PLoS ONE. 2018. May. 1-27 doi: 10.1371/journal.pone.0197046

Yoav Evron, Clark K. Colton, Barbara Ludwig, Gordon C. Weir, Baruch Zimermann, Shiri Maimon, Tova Neufeld, Nurit Shalev, Tali Goldman, Assaf Leon, Karina Yavriyants, Noa Shabtay, Tania Rozenshtein, Dimitri Azarov, Amanda R. DiIenno, Anja Steffen, Paul de Vos, Stefan R. Bornstein, Uriel Barkai & Avi Rotem. Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply. Scientific Reports. 2018. 8:6508. DOI:10.1038/s41598-018-23862-w

Bart J. De Haan, Harry van Goor, and Paul De Vos. Processing of Immunoisolated Pancreatic Islets: Implications for Histological Analyses of Hydrated Tissue. BioTechniques. 2002. 32:612-619 Link to document

L. Alberto Llacua, Arjan Hoek, Bart J. de Haan & Paul de Vos. Collagen type VI interaction improves human islet survival in immunoisolating microcapsules for treatment of diabetes. doi: 10.1080/19382014.2017.1420449

Llacua A, Faas MM, De Vos P . Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets. Diabetologia 2018 doi.org/10.1007/s00125-017-4524-8

Smink AM, Shiri L, Swart DH, Hertsig DT, de Haan BJ, Kamps JAAM, Schwab L, van Apeldoorn AA, de Koning E, Faas MM, Lakey JRT, de Vos P. Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet-transplantation enhances immediate post-transplant islet graft function but not long-term normoglycemia. J Biomed Mater Res A. 2017 doi: 10.1002/jbm.a.36101

Llacua A, de Haan BJ, de Vos P. Laminin and collagen IV inclusion in immunoisolating microcapsules reduces cytokine-mediated cell death in human pancreatic islets. J Tissue Eng Regen Med. 2017 doi: 10.1002/term.2472

Smink AM, Li S, Hertsig DT, De Haan BJ, Schwab L, Van Apeldoorn AA, De Koning E, Faas MM, Lakey JRT, De Vos P (2017) The Efficacy of a Prevascularized, Retrievable Poly(D,L,-lactide-co-e-caprolactone) Subcutaneous Scaffold as Transplantation Site for Pancreatic Islets. Transplantation 101: e112–e119

Paredes-Juarez GA, De Vos P, Bulte JWM (2017) Recent progress in the use and tracking of transplanted islets as a personalized treatment for type 1 diabetes. Expert Review of Precision Medicine and Drug Development http://dx.doi.org/10.1080/23808993.2017.1302305

De Vos P (2017) Historical Perspectives and Current Challenges in Cell Microencapsulation. Methods Mol Biol. DOI 10.1007/978-1-4939-6364-5_1, 1479:3-21. PubMed PMID: 27738923

Krishnan R, Ko D, Foster CE 3rd, Liu W, Smink AM, De Haan B, De Vos P, Lakey JR (2017) Immunological Challenges Facing Translation of Alginate Encapsulated Porcine Islet Xenotransplantation to Human Clinical Trials. Methods Mol Biol. DOI 10.1007/978-1-4939-6364-5_24. PubMed PMID: 27738946.

Smink AM, Hertsig DT, Schwab L, Van Apeldoorn AA, De Koning E, Faas MM, De Haan BJ, De Vos P (2016) A retrievable, efficacious polymeric scaffold for subcutaneous transplantation of rat pancreatic islets. Annals of Surgery doi:10.1097/SLA.0000000000001919

Sambathkumar R, Kalo E, Van Rossom R, Faas MM, De Vos P, Verfaillie CM. (2016) Epigenetic induction of definitive and pancreatic endoderm cell fate in human fibroblasts. Stem Cells Int doi:10.1155/2016/7654321

Smink AM, De Haan BJ, Paredes-Juarez GA, Wolters AHG, Kuipers J, Giepmans BNG, Schwab L, Engelse MA, Van Apeldoorn AA, De Koning E, Faas MM, De Vos P. (2016) Selection of polymers for application in scaffolds applicable for human pancreatic islet transplantation. Biomed. Mater 11(2016)035006. doi:10.1088/1748-6041/11/3/035006

Llacua A, De Haan BJ, Smink AM, De Vos P. (2016) Extracellular matrix components supporting human islet function in alginate-based immunoprotective microcapsules for treatment of diabetes. J Biomed Mater Res Part A 2016:00A:000–000. DOI: 10.1002/jbm.a.35706

Barkai U, Rotem A, De Vos P. (2016) Survival of encapsulated islets: More than a membrane story. World Journal of Transplantation March 24; 6(1): 000-000. doi: 10.5500/wjt.v6.i1.000

De Vos P, Smink AM, Paredes G, Lakey JRT, Kuipers J, Giepmans BNG, De Haan BJ, Faas MM. (2016) Enzymes for pancreatic islet isolation impact chemokine-production and polarization of insulin-producing β-Cells with reduced functional survival of immunoisolated rat islet-allografts as a consequence. PLoS ONE 11(1): e0147992. doi:10.1371/journal.pone.0147992

Paredes-Juarez GA, Sahasrabudhe NM, Tjoelker RS, De Haan BJ, Engelse MA, De Koning EJP, Faas MM, De Vos P. (2015) DAMP production by human islets under low oxygen and nutrients in the presence or absence of an immunoisolating-capsule and necrostatin-1. Scientific Reports 5:14623|DOI:10.1038/srep14623

Orive G, Santos E, Poncelet D, Hernández RM, Pedraz JL, Wahlberg LU, De Vos P, Emerich D (2015) Cell encapsulation: technical and clinical advances. Trends in Pharmacol. Sci. doi: 10.1016/j.tips.2015.05.003

Smelt MJ, Faas MM, de Haan BJ, de Haan A, Vaage JT, De Vos P. (2014) The role of alloresponsive Ly49⁺ NK cells in rat islet allograft failure in the presence and absence of cytomegalovirus. Cell Transplantation. DOI:10.3727/096368913X670930

Bhujbal SV, De Haan BJ, Niclou SP and De Vos P. (2014) A novel multilayer immunoisolating encapsulation system overcoming protrusion of cells. Scientific Reports 4:6856|DOI:10.1038/srep06856

Spasojevic M, Paredes-Juarez GA, Vorenkamp J, De Haan BJ, Schouten AJ, De Vos, P. (2014) Reduction of the Inflammatory Responses against Alginate-Poly-L-Lysine Microcapsules by Anti-Biofouling Surfaces of PEG-b-PLL Diblock Copolymers. PLoS ONE 9(10): e109837. doi:10.1371/journal.pone.0109837

Spasojevic M, Vorenkamp J, Jansen MRPACS, De Vos P and Schouten AJ. (2014) Synthesis and Phase Behavior of Poly(N-isopropylacrylamide)-b- Poly(L-Lysine Hydrochloride) and Poly(N-Isopropylacrylamide- co-Acrylamide)-b-Poly(L-Lysine Hydrochloride). Materials 7, 5305-5326; doi:10.3390/ma7075305

Paredes-Juarez GA, Spasojevic M, Faas MM and De Vos P. (2014) Immunological and technical considerations in application of alginate-based microencapsulation systems. Frontiers in Bioengineering and Biotechnology doi: 10.3389/fbioe.2014.00026

Bhujbal S, Paredes-Juarez GA, Niclou SP, De Vos P. (2014) Factors influencing the mechanical stability of alginate beads applicable for immunoisolation of mammalian cells. Journal of the Mechanical Behavior of Biomedical Materials dx.doi.org/10.1016/j.jmbbm.2014.05.020 (2014)196-208

De Vos P. (2014) Cell encapsulation: ready for the next step. Adv. Drug Deliv. Rev. dx.doi.org/10.1016/j.addr.2014.03.002

Orive G, Emerich D, De Vos P. (2014)  Encapsulate this: the do’s and don’ts. Nature Medicine. doi:10.1038/nm.3486

Paredes-Juarez GA, de Haan BJ, Faas MM and De Vos P. (2014) A technology platform to test the efficacy of purification of alginate. Materials. 2014, 7, 2087-2103; doi:10.3390/ma7032087

Bhujbal SV, De Vos P, Niclou SP. (2014) Drug and cell encapsulation: Alternative delivery options for the treatment of malignant brain tumors. Adv. Drug Deliv. Rev. dx.doi.org/10.1016/j.addr.2014.01.010/67–68 (2014) 142–153

De Vos P, Lazarjani AH, Poncelet D, Faas M. (2014) Polymers in cell encapsulation from an enveloped cell perspective. Adv. Drug Deliv. Rev. doi.org/10.1016/j.addr.2013.11.00567–68 (2014) 15–34

Paredes-Juarez GA, De Haan BJ, Faas MM, De Vos P. (2013) The role of pathogen-associated molecular patterns in inflammatory responses against alginate based microcapsules. Journal of Controlled Release. 172 (2013) 983–992

Spasojevic M, Bhujbal S, Paredes G, de Haan BJ, Schouten AJ, De Vos P. (2013) Considerations in binding diblock copolymers on hydrophilic alginate beads for providing an immunoprotective membrane. J Biomed Mater Res Part A. 2013:00: 000–000. doi: 10.1002/jbm.a.34863

Neufeld T, Ludwig B, Barkai U, Weir GC, Colton CK, Evron Y, Balyura M, Yavriyants K, Zimermann B, Azarov D, Maimon S, Shabtay N, Rozenshtein T, Lorber D, Steffen A, Willenz U, Bloch K, Vardi P, Taube R, De Vos P, Lewis EC, Bornstein SR, Rotem A. (2013) The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs. PLoS ONE. 8(8): e70150. doi:10.1371/journal.pone.0070150

Rokstad AMA, Lacík I, de Vos P, Strand BL. (2014) Advances in biocompatibility and physico-chemical characterization of microspheres for cell encapsulation, Adv. Drug Deliv. Rev. doi.org/10.1016/j.addr.2013.07.01067-68 (2014) 111–130

Groen B, Links TP, Lefrandt JD, van den Berg PP, De Vos P, et al. (2013) Aberrant pregnancy adaptations in the peripheral immune response in type 1 diabetes: A rat model. Plos ONE. 8(6): e65490. doi:10.1371/journal.pone.0065490

Smink AM, Faas MM, De Vos P. (2013) Towards engineering a novel transplantation site for pancreatic islets. Diabetes. 2013 May;62(5):1357-64. doi: 10.2337/db12-1553.

Smelt MJ, de Haan BJ, Faas MM, de Haan A, De Vos P. (2013) Impaired glucose tolerance in rat islet isograft recipients after cytomegalovirus infection. Transpl Infect Dis. DOI: 10.1111/tid.12041

Sobol M, Bartkowiak A, de Haan BJ, De Vos P (2013) Cytotoxicity study of novel water-soluble chitosan derivatives applied as membrane material of alginate microcapsules. JBiomed Mater Re s Part A 101A:1907-1914

Barkai U, Weir GC, Colton CK, Ludwig B, Bornstein SR, Brendel MD, Neufeld T, Bremer C, Leon A, Evron Y, Yavriyants K, Azarov D, Zimermann M, Shabtay MMN, Balyura M, Rozenshtein T, Vardi P, Bloch K, de Vos P, and Rotem A. (2013) Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplantation 1463-1476 DOI information: 10.3727

De Vos P, Spasojevic M, de Haan BJ, Faas MM. (2012) The association between in vivo physicochemical changes and inflammatory responses against alginate based microcapsules. Biomaterials 1-8 DOI infromation: 10.1016

Ludwig B, Rotem A, Schmid J, Weir GC, Colton CK, Brendel MD, Neufeld T, Block NL, Yavriyants K, Steffen A, Ludwig S, Chavakis T, Reichel A, Azarov D, Zimermann B, Maimon S, Balyura M, Rozenshtein T, Shabtay N, Vardi P, Bloch K, De Vos P, Schally AV, Bornstein SR, Barkai U. (2012) Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci USA doi/10.1073/pnas.1201868109

Smelt MJ, Faas MM, de Haan BJ, de Haan A, De Vos P. (2012), Cytomegalovirus increases the immunogenicity of human beta-cells. Pancreas. 2012; 41: 39-49

Smelt MJ, Faas MM, de Haan BJ, de Haan A, De Vos P. (2011), The effects of cytomegalovirus on islet allograft function and allograft rejection. Cell Transplantation. 20(8):1271-83

de Haan BJ , Rossi A, Faas MM, Smelt MJ, Sonvico F, Colombo P, De Vos P. (2011) Structural surface changes and inflammatory responses against alginate based microcapsules after exposure to human peritoneal fluid. J Biomed Mater Res A . 98(3):394-403

de Vos P, Spasojevic M, Faas MM. (2010) Treatment of diabetes with encapsulated islets. Adv Exp Med Biol. 670:38-53

Tam SK, de Haan BJ, Faas MM, Hallé JP, Yahia L, De Vos P. (2009), Adsorption of human immunoglobulin to implantable alginate-poly-L-lysine microcapsules: Effect of microcapsule composition. J Biomed Mater Res A . 89, 3, 609-15

De Vos P, Bučko M, Gemeiner P, Navrátil M, Svitel J, Faas MM, Strand BL, Skjak-Braek G, Morch YA, Vikartovská A, Lacík I, Kolláriková G, Orive G, Poncelet D,Pedraz JL,Ansorge-Schumacher MB. (2009), Multiscale requirements for bioencapsulation in medicine and biotechnology. Biomaterials. 30, 2559-2570

De Vos P, de Haan BJ, Kamps JAAM, Faas MM, Kitano T. (2007) Zeta-potentials of alginate-PLL capsules: a predictive value for biocompatibility? J Biomed Mater Res A. 813-819

Gangaram-Panday ST, Faas MM, De Vos P. (2007) Towards stem-cell therapy in the endocrine pancreas. Trends Mol Med. 13(4): 164-173

De Vos P, Andersson A, Tam SK, Faas MM and Hallé JP. (2006) Advances and Barriers in Mammalian Cell Encapsulation for Treatment of Diabetes Immun., Endoc. & Metab. Agents in Med. Chem., 6, 139-153

Ponce S, Orive G, Hernandez R, Gascon AR, Pedraz JL, de Haan BJ, Faas MM,Mathieu HJ, de Vos P. (2006) Chemistry and the biological response against immunoisolating alginate-polycation capsules of different composition. Biomaterials. 27(28):4831-9

De Vos P, Faas MM, Strand B, Calafiore R. (2006) Alginate-based microcapsules for immunoisolation of pancreatic islets. Biomaterials. 27:5603-5617

Bünger CM, Gerlach G,Freier TH, Pilz M, Werner C, De Vos P. (2005) Deletion of tissue responses against immunoisolating alginate-PLL capsules by temporary release of steroids. Biomaterials. 26 :2353-2360

Orive G, Hernandez RM, Gascon AR, Calafiore R, De Vos P, Hortelano G, Hunkelar D, Lacik I, Pedraz JL. (2004) History, challenges and perspectives of cell microencapsulation. Trends in Biotechnology. 22:87-92

de Haan BJ, Faas MM, de Leij LFM, De Vos P. (2004) Factors influencing isolation of functional pancreatic islets. Pancreas. 29 :15-22

Visser L, Poppema S, De Haan BJ, Klok P, De Vos P. (2004) Prolonged survival of rat-islet xenografts in mice by CD45 RB antibody monotherapy. Transplantation. 77:386-391

Orive G, Hernandez RM, Gascon AR, Calafiore R, Chang TMS, de Vos P, Hortelano G,Hunkelar D, Lacik I, Shapiro AMJ, Pedraz JL. (2003) Cell encapsulation: promise and progress. Nature Medicine. 9:104-107

de Vos P, van Hoogmoed CG, van Zanten J, Netters S, Strubbe JH, Busscher HJ. (2003) Long-term biocompatibility, chemistry, and function of microencapsulated islets. Biomaterials. 24:305-312

Omer A, Keegan M, Czismadia E, de Vos P, van Rooijen N, Bonner-Weir S, Bach F,Weir G. (2003) Macrophage depletion improves survival of neonatal porcine pancreatic cell clusters contained in alginate macrocapsules transplantedinto rats. Xenotransplantation. 10:240-251

De Vos P, Smedema I, van Goor H, Moes H, van Zanten J, Lou FM de Leij, de Haan BJ. (2003) Association between macrophage activation and function of microencapsulated islets. Diabetologia. 46:666-673

van Hoogmoed CH, Busscher HJ, De Vos P. (2003) FT-IR studies of alginate containing microcapsules. J Biomed Mat Res A. 67: 172-178

Bünger CM, Gerlach G, Freier TH, Pilz M, Werner C, de Vos P. (2003) Biocompatibility and surface structure of chemically modified immunoisolating alginate-PLL capsules. J Biomed Mat Res A. 67:1219-1227

de Haan BJ, Faas MM, De Vos P. (2003) Factors influencing insulin secretion from encapsulated islets. Cell Transplantation 12:617-625

de Vos P, Smedema I, van Goor H, Moes H, van Zanten J, Netters S, de Leij LFM, de Haan A, de Haan BJ. (2003) Association between macrophage activation and function of microencapsulated rat islets. Diabetologia. 46:666-673

De Vos P, van Hoogmoed CG, Busscher HJ. (2002) Chemistry and biocompatibility of alginate-PLL capsules for immunoprotection of mammalian cells. J Biomed Mat Res A. 60:252-259

De Vos P, Hamel BJ, Tatarkiewicz K. (2002) Considerations for successful transplantation of microencapsulated pancreatic islets. Diabetologia. 45:189-173

De Vos P, van Hoogmoed CH, de Haan BJ, Busscher HJ. (2002) Tissue responses against immunoprotective microcapsules in the immediate posttransplant period. J Biomed Mat Res A. 62:430-437

De Vos P, Marchetti P. (2002) Immunoisolation of pancreatic islets-the untouchables. Trends in Molecular Medicine. 8:363-366

Tatarkiewicz K, Garcia M, Omer A, van Schilfgaarde R, Weir CG, De Vos P. (2001) C-peptide responses after meal challenge in mice transplanted with microencapsulated rat islets. Diabetologia. 44:646-653

Del-Guerra S, Bracci C, Nilsson K, Belcourt A, Kessler L, Lupi R, Marselli L, De Vos P, Marchetti P.(2001) Entrapment of dispersed pancreatic islet cells in CultiSpher-S macroporous gelatin microcarriers: Preparation, in vitro characterization, and microencapsulation. Biotechnol-Bioeng. 75: 741-744

Uludag H, De Vos P, Tresco P. (2000) Encapsulation of mammalial cells. Theoretical and technical considerations. J Adv Drug Delivery Reviews. 42;29-64

De Vos P, Nieuwenhuizen A, van Straaten JFM, de Haan BJ, van Schilfgaarde R. (1999) Why do encapsulat­ed islets fail in the absence of fibrotic overgrowth. Diabetes. 48:1381-1388

De Vos P, de Haan BJ, Wolters GHJ, Strubbe JH, van Schilfgaarde R. (1997) Improved biocompa­tibility but limited graft survival after purification of alginate for microencapsul­tion of pancreatic islets. Diabetologia. 40:262-270

De Vos P, Hillebrands JL, de Haan BJ, Strubbe JH, van Schilfgaar­de R. (1997) The efficacy of a prevasculariz­ed ePTFE solid support system as a transplantation site for pancrea­tic islets. Transplantation. 18:1085-1090

de Vos P, de Haan BJ, van Schilfgaarde R. (1997) Upscaling the production of encapsu­lated pancreatic islets. Biomaterials. 18:1085-109

De Vos P, de Haan BJ, van Schilfgaar­de R. (1997) The effect of the alginate composition on the biocompatibili­ty of alginate-polylysine microcapsules. Biomaterials. ­18:273-278

De Vos P, de Haan BJ, Strubbe JH, Bruggink JE, van Schilfgaar­de R. (1996) Kinetics of intraperitoneally infused insulin in rats: functional implications for the bioartificial pancreas. Diabetes. 45:1103-1106

de Vos P, de Haan BJ, Pater J, van Schilfgaarde R. (1996) Association between capsules diameter, adequacy of encapsulation, and survival of microencapsulated rat islet allo­grafts. Transplantation 62:893-899

De Vos P, de Haan BJ, Wolters GHJ, van Schilfgaarde R. (1996) Factors influencing the adequacy of microencapsulation of rat pancreatic islets. Transplantation. 62:888-893