Scheffers group Publications
Please find an overview of publications below.
2024
Cavalca,
L., Atlason, Ú. Á., Trofin, A.,
Ribeiro, C. M., Pavan, F. R., Deuss, P. J.,
& Scheffers, D.-J. (2024). Selectivity and
Activity of Benzene-1,2,4-triol and its Dimers as Antimicrobial
Compounds Against Xanthomonas citri subsp. citri.
ChemPlusChem, 89(6), Article
e202300616. https://doi.org/10.1002/cplu.202300616
van
Groesen, E., Mons, E., Kotsogianni, I., Arts, M., Tehrani, K. H. M.
E., Wade, N., Lysenko, V., Stel, F. M., Zwerus, J. T., De
Benedetti, S., Bakker, A., Chakraborty, P., van der
Stelt, M., Scheffers, D.-J., Gooskens, J., Smits, W.
K., Holden, K., Gilmour, P. S., Willemse, J., ... Martin, N. I.
(2024). Semisynthetic guanidino lipoglycopeptides with potent
in vitro and in vivo antibacterial activity.
Science Translational Medicine,
16(759), Article eabo4736. https://doi.org/10.1126/scitranslmed.abo4736
2023
Bramkamp,
M., & Scheffers, D.-J. (2023). Bacterial
membrane dynamics: Compartmentalization and repair.
Molecular Microbiology, 120(4),
Article 15077. https://doi.org/10.1111/mmi.15077
Ziylan,
Z. S., de Putter, G. J., Roelofs, M., van Dijl, J.
M., Scheffers, D. J., & Walvoort, M.
T. C. (2023). Evaluation of Kdo-8-N3
incorporation into lipopolysaccharides of various Escherichia
coli strains. RSC Chemical
Biology, 4(11), 884–893. https://doi.org/10.1039/d3cb00110e
2021
Chakraborty,
P., Oosterhuis, D., Bonsignore, R., Casini,
A., Olinga, P., & Scheffers, D.-J.
(2021). An organogold compound as potential antimicrobial
agent against drug resistant bacteria: Initial mechanistic
insights. ChemMedChem,
16(19), 3060-3070. https://doi.org/10.1002/cmdc.202100342
Polaquini,
C. R., Marques, B. C., Ayusso, G. M., Morão, L. G., Sardi, J.
C. O., Campos, D. L., Silva, I. C., Cavalca, L.
B., Scheffers, D.-J., Rosalen, P. L., Pavan, F.
R., Ferreira, H., & Regasini, L. O. (2021). Antibacterial
activity of a new monocarbonyl analog of curcumin MAC 4 is
associated with divisome disruption. Bioorganic
Chemistry, 109, Article 104668. https://doi.org/10.1016/j.bioorg.2021.104668
Cavalca,
L. B., Lahive, C. W., Gijsbers, F., Pavan, F.
R., Scheffers, D.-J., & Deuss, P. J.
(2021). Benzenetriol-Derived Compounds against Citrus
Canker. Molecules, 26(5),
Article 1436. https://doi.org/10.3390/molecules26051436
2020
Li,
Z., Chakraborty, P., de Vries, R. H.,
Song, C., Zhao, X., Roelfes, G.,
Scheffers, D.-J., & Kuipers, O. P. (2020).
Characterization of two relacidines belonging to a novel
class of circular lipopeptides that act against Gram-negative
bacterial pathogens. Environmental
Microbiology, 22(12), 5125-5136. https://doi.org/10.1111/1462-2920.15145
Zielińska,
A., Savietto, A., de Sousa Borges, A., Martinez, D., Berbon,
M., Roelofsen, J. R., Hartman, A. M., de Boer,
R., Van der Klei, I. J., Hirsch, A.
K., Habenstein, B., Bramkamp, M., & Scheffers,
D.-J. (2020). Flotillin-mediated membrane fluidity
controls peptidoglycan synthesis and MreB movement.
eLife, 9, 1-21. Article e57179. https://doi.org/10.7554/eLife.57179
Morao,
L. G., Lorenzoni, A. S. G., Chakraborty, P., Ayusso,
G. M., Cavalca, L. B., Santos, M. B., Marques, B. C.,
Dilarri, G., Zamuner, C., Regasini, L. O., Ferreira, H.,
& Scheffers, D.-J. (2020). Investigating the Modes
of Action of the Antimicrobial Chalcones BC1 and T9A.
Molecules, 25(20), Article 4596. https://doi.org/10.3390/molecules25204596
Li,
Z., de Vries, R. H., Chakraborty, P.,
Song, C., Zhao, X., Scheffers,
D.-J., Roelfes, G., & Kuipers, O.
P. (2020). Novel modifications of nonribosomal
peptides from Brevibacillus laterosporus MG64 and investigation of
their mode of action. Applied and environmental
microbiology, 86(24), 1-14. Article e01981-20.
https://doi.org/10.1128/AEM.01981-20
Morales
Angeles, D., & Scheffers, D.-J. (2020). The
Cell Wall of Bacillus subtilis. Current Issues in
Molecular Biology, 41, 539-596. https://doi.org/10.21775/cimb.041.539
2019
Morales
Angeles, D., Macia Valero, A., Bohorquez Suarez,
L., & Scheffers, D.-J. (2020). The PASTA
domains of Bacillus subtilis PBP2B stabilize the interaction of
PBP2B with DivIB. Microbiology,
166(9), 826–836. Article 000957. https://doi.org/10.1099/mic.0.000957
Polaquini,
C. R., Morão, L. G., Nazaré, A. C., Torrezan, G. S.,
Dilarri, G., Cavalca, L. B., Campos, D. L., Silva, I.
C., Pereira, J. A., Scheffers, D.-J., Duque, C.,
Pavan, F. R., Ferreira, H., & Regasini, L. O. (2019).
Antibacterial activity of 3,3'-dihydroxycurcumin (DHC) is
associated with membrane perturbation. Bioorganic
Chemistry, 90, Article 103031. https://doi.org/10.1016/j.bioorg.2019.103031
2018
Morão,
L. G., Polaquini, C. R., Kopacz, M., Torrezan, G. S., Ayusso, G.
M., Dilarri, G., Cavalca, L. B., Zielińska, A.,
Scheffers, D.-J., Regasini, L. O., & Ferreira, H.
(2019). A simplified curcumin targets the membrane of
Bacillus subtilis. MicrobiologyOpen,
8(4), Article 683. https://doi.org/10.1002/mbo3.683
Kopacz,
M. M., Lorenzoni, A. S. G., Polaquini, C. R., Regasini, L.
O., & Scheffers, D.-J. (2019). Purification
and characterization of FtsZ from the citrus canker pathogen
Xanthomonas citri subsp. citri.
MicrobiologyOpen, 8(5), Article
e00706. https://doi.org/10.1002/mbo3.706
Savietto,
A., Polaquini, C. R., Kopacz, M., Scheffers, D.-J.,
Marques, B. C., Regasini, L. O., & Ferreira, H. (2018).
Antibacterial activity of monoacetylated alkyl gallates
against Xanthomonas citri subsp citri. Archives of
Microbiology, 200(6), 929-937. https://doi.org/10.1007/s00203-018-1502-6
Nazaré,
A. C., Polaquini, C. R., Cavalca, L. B., Anselmo, D.
B., Saiki, M. D. F. C., Monteiro, D. A., Zielinska,
A., Rahal, P., Gomes, E., Scheffers, D.-J.,
Ferreira, H., & Regasini, L. O. (2018). Design of
Antibacterial Agents: Alkyl Dihydroxybenzoates against Xanthomonas
citri subsp. citri. International Journal of
Molecular Sciences, 19(10), 1-15. https://doi.org/10.3390/ijms19103050
2017
Dockerty,
P., Edens, J. G., Tol, M. B., Morales Angeles, D., Domenech Pena,
A., Liu, Y., Hirsch, A. K. H., Veening, J.-W.,
Scheffers, D.-J., & Witte, M. D. (2017).
Bicyclic enol cyclocarbamates inhibit penicillin-binding
proteins. Organic & Biomolecular
Chemistry, 15(4), 894-910. https://doi.org/10.1039/c6ob01664b
Król,
E., de Sousa Borges, A., Kopacz, M., & Scheffers,
D.-J. (2017). Metal-dependent SpoIIE oligomerization
stabilizes FtsZ during asymmetric division in Bacillus
subtilis. PLoS ONE, 12(3),
Article e0174713. https://doi.org/10.1371/journal.pone.0174713
Morales
Angeles, D., Liu, Y., Hartman, A. M., Borisova, M., de
Sousa Borges, A., de Kok, N., Beilharz, K., Veening,
J.-W., Mayer, C., Hirsch, A. K. H., &
Scheffers, D.-J. (2017). Pentapeptide-rich
peptidoglycan at the Bacillus subtilis cell-division site.
Molecular Microbiology, 104(2),
319-333. https://doi.org/10.1111/mmi.13629
Soibelmann
Glock Lorenzoni, A., Dantas, G., Bergsma, T., Ferreira, H.,
& Scheffers, D. (2017). Xanthomonas citri MinC
Oscillates from Pole to Pole to Ensure Proper Cell Division and
Shape. Frontiers in Microbiology,
8, 1-12. Article 1352. https://doi.org/10.3389/fmicb.2017.01352
2016
de
Sousa Borges, A., & Scheffers, D.-J. (2016).
Bacterial dynamin as a membrane puncture repair kit.
Environmental Microbiology, 18(8),
2298-2301. https://doi.org/10.1111/1462-2920.13218
Pereira,
A. R., Hsin, J., Król, E., Tavares, A. C.,
Flores, P., Hoiczyk, E., Ng, N., Dajkovic, A., Brun, Y. V.,
VanNieuwenhze, M. S., Roemer, T., Carballido-Lopez, R.,
Scheffers, D.-J., Huang, K. C., & Pinho, M. G. (2016).
FtsZ-Dependent Elongation of a Coccoid Bacterium.
mBio, 7(5), 1-9. Article e00908-16 .
https://doi.org/10.1128/mBio.00908-16
2015
Trip,
E. N., & Scheffers, D.-J. (2015). A
1 MDa protein complex containing critical components of the
Escherichia coli divisome. Scientific
Reports, 5, Article 18190. https://doi.org/10.1038/srep18190
Krol,
E., de Sousa Borges, A., da Silva, I., Polaquini, C.,
Regasini, L., Ferreira, H., & Scheffers, D.
(2015). Antibacterial activity of alkyl gallates is a
combination of direct targeting of FtsZ and permeabilization of
bacterial membranes. Frontiers in
Microbiology, 6, Article 390. https://doi.org/10.3389/fmicb.2015.00390
Silva,
I., Pavan, F. R., Polaquini, C., Regasini, L. O., Scheffers,
D. .-J., & Ferreira, H. (2015). Assessment of
cyto/genotoxicity of the antibacterial heptyl gallate in HepG2
cells and the possible target in bacteria.
Toxicology Letters, 238(2,
Supplement), S328-S328. https://doi.org/10.1016/j.toxlet.2015.08.935
Tol,
M. B., Angeles, D. M., & Scheffers, D.-J. (2015).
In vivo cluster formation of nisin and Lipid II is correlated
with membrane depolarization. Antimicrobial Agents
and Chemotherapy, 59(6), 3683-3686. https://doi.org/10.1128/AAC.04781-14
Scheffers,
D.-J., & Tol, M. B. (2015). LipidII: Just Another
Brick in the Wall? PLoS Pathogens,
11(12), Article e1005213. https://doi.org/10.1371/journal.ppat.1005213
de
Sousa Borges, A., de Keyzer, J., Driessen, A. J.
M., & Scheffers, D.-J. (2015). The
Escherichia coli membrane protein insertase YidC assists in the
biogenesis of Penicillin Binding Proteins. Journal
of Bacteriology, 197, 1444-1450. https://doi.org/10.1128/JB.02556-14
2014
Geng,
Y., Keyzer, J. D., Scheffers, D.-J., &
Driessen, A. J. M. (2014). Defining the Region of
Bacillus subtilis SpoIIIJ That Is Essential for Its
Sporulation-Specific Function. Journal of
Bacteriology, 196(7), 1318-1324. https://doi.org/10.1128/JB.01084-13
2013
Scheffers,
DJ. (2013). Bacterial Reproduction and Growth.
In eLS Wiley. https://doi.org/10.1002/9780470015902.a0001419.pub2
Trip,
E. N., Veening, J.-W., Stewart, E. J., Errington, J., &
Scheffers, D.-J. (2013). Balanced transcription of
cell division genes in Bacillus subtilis as revealed by single cell
analysis. Environmental Microbiology,
15(12), 3196-3209. https://doi.org/10.1111/1462-2920.12148
Boekema,
E. J., Scheffers, D.-J., van Bezouwen, L. S., Bolhuis,
H., & Folea, I. M. (2013). Focus on Membrane
Differentiation and Membrane Domains in the Prokaryotic
Cell. Journal of Molecular Microbiology and
Biotechnology, 23(4-5), 345-356. https://doi.org/10.1159/000351361
Król,
E., & Scheffers, D.-J. (2013). FtsZ
Polymerization Assays: Simple Protocols and Considerations.
Journal of Visualized Experiments, (81),
e50844-1-e50844-13. https://doi.org/10.3791/50844
Ballesteros-Plaza,
D., Holguera, I., Scheffers, D.-J., Salas, M., &
Munoz-Espin, D. (2013). Phage phi 29 protein p1 promotes
replication by associating with the FtsZ ring of the divisome in
Bacillus subtilis. Proceedings of the National
Academy of Sciences of the United States of America,
110(30), 12313-12318. https://doi.org/10.1073/pnas.1311524110
Lages,
M. C. A., Beilharz, K., Angeles, D. M., Veening, J.-W., &
Scheffers, D.-J. (2013). The localization of key
Bacillus subtilis penicillin binding proteins during cell growth is
determined by substrate availability.
Environmental Microbiology, 15(12),
3272-3281. https://doi.org/10.1111/1462-2920.12206
2012
Krol,
E., van Kessel, S. P., van Bezouwen, L.
S., Kumar, N., Boekema, E. J., & Scheffers,
D.-J. (2012). Bacillus subtilis SepF Binds to the
C-Terminus of FtsZ. PLoS ONE,
7(8), Article e43293. https://doi.org/10.1371/journal.pone.0043293
Scheffers,
D.-J. (2012). Cell wall synthesis in Bacillus
subtilis. In P. Graumann (Ed.), Bacillus: Cellular and
Molecular Biology (pp. 285-318). Caister Academic Press.
Scheffers,
D.-J. (2012). The Cell Wall of Bacillus
subtilis. In P. Graumann (Ed.), Bacillus: Cellular and
Molecular Biology (2 ed.). Caister Academic Press.
2011
Yu,
Z., Bekker, M., Tramonti, A., Cook, G. M., van Ulsen, P.,
Scheffers, D.-J., de Mattos, J. T., De Biase, D., &
Luirink, J. (2011). Activators of the Glutamate-Dependent
Acid Resistance System Alleviate Deleterious Effects of YidC
Depletion in Escherichia coli. Journal of
Bacteriology, 193(6), 1308-1316. https://doi.org/10.1128/JB.01209-10
Guendogdu,
M. E., Kawai, Y., Pavlendova, N., Ogasawara, N., Errington,
J., Scheffers, D.-J., Hamoen, L. W., &
Gündoğdu, M. E. (2011). Large ring polymers align
FtsZ polymers for normal septum formation. EMBO
Journal, 30(3), 617-626. https://doi.org/10.1038/emboj.2010.345
2010
Fernandes
de Oliveira, I. F., Sousa Borges, A. D., Kooij, V.,
Bartosiak-Jentys, J., Luirink, J., & Scheffers,
D.-J. (2010). Characterization of ftsZ Mutations that
Render Bacillus subtilis Resistant to MinC. PLoS
ONE, 5(8), Article e12048. https://doi.org/10.1371/journal.pone.0012048
Ribeiro,
J. P., Palczewska, M., André, S., Cañada, F. J., Gabius,
H.-J., Jiménez-Barbero, J., Mellström, B., Naranjo, J.
R., Scheffers, D.-J., & Groves, P. (2010).
Diffusion nuclear magnetic resonance spectroscopy detects
substoichiometric concentrations of small molecules in protein
samples. Analytical Biochemistry,
396(1), 117-123. https://doi.org/10.1016/j.ab.2009.09.001
2009
Pop,
O. I., Soprova, Z., Koningstein, G., Scheffers, D.-J.,
Ulsen, P. V., Wickström, D., Gier, J.-W. D., & Luirink, J.
(2009). YidC is required for the assembly of the MscL
homopentameric pore. The FEBS Journal,
276(17), 4891-4899. https://doi.org/10.1111/j.1742-4658.2009.07188.x
2008
Formstone,
A., Carballido-López, R., Noirot, P., Errington, J.,
& Scheffers, D.-J. (2008). Localization and
Interactions of Teichoic Acid Synthetic Enzymes in Bacillus
subtilis. Journal of Bacteriology,
190(5), 1812-1821. https://doi.org/10.1128/JB.01394-07
Scheffers,
D.-J. (2008). The effect of MinC on FtsZ
polymerization is pH dependent and can be counteracted by
ZapA. FEBS Letters, 582(17),
2601-2608. https://doi.org/10.1016/j.febslet.2008.06.038
2007
Scheffers,
D.-J. (2007). Cell wall growth during elongation and
division: one ring to bind them? Molecular
Microbiology, 64(4), 877-880. https://doi.org/10.1111/j.1365-2958.2007.05731.x
Scheffers,
D.-J., Robichon, C., Haan, G. J., Blaauwen, T. D.,
Koningstein, G., Bloois, E. V., Beckwith, J., &
Luirink, J. (2007). Contribution of the FtsQ Transmembrane
Segment to Localization to the Cell Division Site.
Journal of Bacteriology, 189(20),
7273-7280. https://doi.org/10.1128/JB.00723-07
2005
Scheffers,
D.-J., & Pinho, M. G. (2005). Bacterial Cell Wall
Synthesis: New Insights from Localization Studies.
Microbiology and Molecular Biology Reviews,
69(4), 585-607. https://doi.org/10.1128/MMBR.69.4.585-607.2005
Scheffers,
D.-J. (2005). Dynamic localization of
penicillin-binding proteins during spore development in Bacillus
subtilis. Microbiology,
151(3), 999-1012. https://doi.org/10.1099/mic.0.27692-0
2004
Scheffers,
D.-J., & Errington, J. (2004). PBP1 Is a Component
of the Bacillus subtilis Cell Division Machinery.
Journal of Bacteriology, 186(15),
5153-5156. https://doi.org/10.1128/JB.186.15.5153-5156.2004
Koppelman,
CM., Aarsman, MEG., Postmus, J., Pas, E., Muijsers, AO.,
Scheffers, DJ., Nanninga, N., & den Blaauwen, T. (2004).
R174 of Escherichia coli FtsZ is involved in membrane
interaction and protofilament bundling, and is essential for cell
division. Molecular Microbiology,
51(3), 645-657. https://doi.org/10.1046/j.1365-2958.2003.03876.x
Scheffers,
D.-J., Jones, L. J. F., & Errington, J. (2004).
Several distinct localization patterns for penicillin-binding
proteins in Bacillus subtilis. Molecular
Microbiology, 51(3), 749-764.
2003
Errington,
J., Daniel, R. A., & Scheffers, D.-J. (2003).
Cytokinesis in Bacteria. Microbiology and
Molecular Biology Reviews, 67(1), 52-65. https://doi.org/10.1128/MMBR.67.1.52-65.2003
2002
Scheffers,
D.-J., de Wit, J. G., Blaauwen, T. D., & Driessen,
A. J. M. (2002). GTP hydrolysis of cell division
protein FtsZ: Evidence that the active site is formed by the
association of monomers: Evidence that the Active Site Is Formed by
the Association of Monomers.
Biochemistry, 41(2), 521 - 529. https://doi.org/10.1021/bi011370i
Scheffers,
D.-J., & Driessen, A. J. M. (2002).
Immediate GTP hydrolysis upon FtsZ polymerization.
Molecular Microbiology, 43(6), 1517
- 1521. https://doi.org/10.1046/j.1365-2958.2002.02828.x
2001
Scheffers,
D.-J. (2001). Polymerization of the bacterial cell
division protein FtsZ. s.n.
Scheffers,
D.-J., de Wit, J. G., Blaauwen, T. D., & Driessen,
A. J. M. (2001). Substitution of a conserved aspartate
allows cation-induced polymerization of FtsZ. FEBS
Letters, 494(1-2), 34 - 37. https://doi.org/10.1016/S0014-5793(01)02310-9
Scheffers,
D.-J., & Driessen, A. J. M. (2001).
The polymerization mechanism of the bacterial cell division
protein FtsZ. FEBS Letters,
506(1), 6 - 10. https://doi.org/10.1016/S0014-5793(01)02855-1
2000
Scheffers,
D. J., den Blaauwen, T., & Driessen, A. J.
(2000). Non-hydrolysable GTP-gamma-S stabilizes the FtsZ
polymer in a GDP-bound state. Molecular
Microbiology, 35(5), 1211-1219. https://doi.org/10.1046/j.1365-2958.2000.01791.x
Last modified: | 09 June 2023 8.36 p.m. |