PhD ceremony: Ms. M.K.S. van Duijl-Richter, 11.00hrs, Academiegebouw, Broerstraat 5, Groningen
Dissertation: Dengue and Chikungunya Virus. Cell Entry Mechanisms and the Impact of Antibodies on Infectivity
Promotor(s): prof.dr. J.M. Smit, prof.dr. A.M. van Oijen
Faculty: Medical Sciences / UMCG
Dengue virus (DENV) and Chikungunya virus (CHIKV) are rapidly emerging viruses that are prevalent in the tropical and subtropical regions of world. Both viruses are transmitted to humans by mosquitoes of the Aedes species, which include the yellow fever mosquito and the Asian tiger mosquito. DENV can cause dengue fever, which is characterized by flu-like symptoms. Also, yearly about 500,000 patients develop more severe dengue, which can be fatal if not properly treated.
CHIKV causes chikungunya fever, with symptoms including high fever, rash, headache, and muscle and joint pain. Approximately 12-49% of CHIKV-infected patients develop chronic debilitating joint pain, which persists from months to years. No specific antiviral treatment or vaccine is available for either of the viruses and treatment is focused on relieving the disease symptoms. For the rational design of vaccines and antiviral drugs it is imperative to better understand the dynamic interactions that occur between the virus and the host during virus reproduction.
The research described in this thesis focuses on the early events in DENV and CHIKV infection. We aimed to further investigate the molecular mechanisms that are involved in viral cell entry. For DENV, we focused on the role of the viral precursor membrane (prM) protein in virus infectivity and how antibodies control the infectious properties of the virus. For CHIKV, we dissected the viral entry pathway and the molecular mechanisms of viral membrane fusion. In addition, we investigated the working mechanism of potent, fusion-inhibitory antibodies against CHIKV.
The Royal Netherlands Academy of Arts and Sciences (KNAW) has appointed Professor Siewert-Jan Marrink and Professor Judith Rosmalen as members of the Academy. Members of the KNAW, prominent academics from all disciplines, are chosen on the basis of...
Mensen met post-COVID ervaren levensveranderende beperkingen. Ze zijn mentaal en fysiek ontregeld, ervaren veel onzekerheid en de impact op hun dagelijks leven is groot. Dit blijkt uit onderzoek van het UMCG naar de persoonlijke en maatschappelijke...
Three promising PhD graduates from the University of Groningen will be able to conduct research at top institutes abroad for two years thanks to the Rubicon programme organized by the Netherlands Organisation for Scientific Research (NWO) and...
The UG website uses functional and anonymous analytics cookies. Please answer the question of whether or not you want to accept other cookies (such as tracking cookies).
If no choice is made, only basic cookies will be stored. More information