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Research GBB Biotransformation and Biocatalysis

Biotransformation and Biocatalysis

Head: Prof. Dr. D.B. Janssen and Prof. Dr. M.W. Fraaije

The unit Biotransformation and Biocatalysis group includes 2 groups: Chemical Biotechnology (Prof.dr. D.B. Janssen) and Molecular Enzymology (Prof.dr. M.W. Fraaije). Research is aimed at obtaining insight in the enzymology of the microbial transformation of synthetic compounds, and the development of improved biocatalysts for such transformations. The groups investigate catalytic mechanisms, kinetic properties, and structure-function relationships in enzymes that can be used for regio- and enantioselective synthesis reactions for preparing fine chemicals, or for valorization of biomass-derived compounds. Obtaining new enzymes by enrichment, genome mining, and high-throughput screening as well as their improvement by structure-inspired directed evolution are important parts of this work. Applications are developed in various programs with external partners.

Enzyme discovery, characterization and engineering for new applications.
Enzyme discovery, characterization and engineering for new applications.

The group headed by Prof. Marco Fraaije focuses on redox enzymes, including monooxygenases, oxidases and peroxidases, and uses rational enzyme engineering and directed evolution to control enzyme properties and develop new conversions. For details, see:

The group headed by Prof. Dick Janssen investigates mainly hydrolytic enzymes, lyases and transferases, and explores computational approaches for stability and selectivity engineering and for tailoring enzyme properties for use in applied biocatalysis. For details see:

Last modified:15 November 2019 1.58 p.m.