Reducing salt intake may help protect kidney patients' heart and kidney health
New research indicates that reducing sodium intake may provide kidney and heart benefits for patients with chronic kidney disease (CKD). The findings appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN).
Urinary excretion of proteins, including albumin, is a hallmark of CKD. Therapies that reduce such albuminuria can slow kidney function decline and also have beneficial effects on the heart and blood vessels. Unfortunately, currently available therapies do not eliminate albuminuria in many patients, leaving these individuals with what is known as residual albuminuria.
Reducing residual albuminuria
A team led by Martin de Borst, MD, PhD (University Medical Center Groningen) studied 2 interventions that have demonstrated potential for reducing residual albuminuria: dietary sodium restriction and a drug (paricalcitol) that activates the vitamin D receptor. In a randomized trial that included 45 patients with CKD, each intervention was added to an optimized conventional treatment regimen during four 8-week periods.
The investigators found that dietary sodium restriction led to a significant reduction of residual albuminuria and blood pressure, whereas paricalcitol had no significant effect on these measures. The combination of paricalcitol and a low sodium diet, however, resulted in the lowest albuminuria levels.
“What we found was that sodium restriction provided a relatively large beneficial effect, whereas the effect of paricalcitol was small. Thus, the impact of the combined intervention was largely due to the protective effect of sodium restriction,” said Dr. de Borst.
Reducing sodium intake
Most people consume twice as much sodium as the 2 grams per day recommended by the World Health Association. “In our study, patients consumed on average 4 grams of sodium per day, which is well in line with global trends in sodium consumption among CKD patients,” said Dr. de Borst. “Interestingly, following our intervention aimed at reduced sodium intake, patients consumed 2.5 grams per day, which is still above the recommended level. This moderate restriction resulted in a strong reduction in albuminuria and blood pressure, indicating that even a moderate reduction in sodium intake may provide serious health benefits.”
Last modified: | 12 March 2020 9.43 p.m. |
More news
-
26 January 2023
Comprehensive medical PhD dissertation presents predictors of inflammatory bowel disease
A PhD dissertation consisting of more than 1100 pages and covering a total of 31 chapters. UMCG PhD-candidate Arno Bourgonje (26) probably wrote the most voluminous medical PhD dissertation ever published in the Netherlands.
Under the supervision...
-
23 January 2023
Video lecture Roelof Hut: Having trouble waking up? This is how you can become a morning person
In this video lecture from the University of the Netherlands, neuroscientist Roelof Hut (University of Groningen, UMCG) talks about the biological clock. Can you become a morning person? Watch this video lecture for tips!
-
16 January 2023
Loneliness and depression
Blue Monday is the name that was once given to the supposedly most depressing day of the year. On this day, the UG would like to draw attention to research on depression. Whether there is a relationship between loneliness and depression, what exactly...