Skip to ContentSkip to Navigation
About us Latest news News News articles

WNT signaling in airway remodeling in asthma

11 February 2015

Novel roles for WNT-5A in airway smooth muscle

PhD ceremony:

Mr K. Kumawat

When:

February 20, 2015

Start:

16:15

Promotors:

prof. dr. R. (Reinoud) Gosens , prof. dr. M. (Martina) Schmidt

Where:

Academy building RUG

The thesis of Kuldeep Kumawat unravels several molecular pathways and factors involved in WNT mediated airway remodeling in asthma and provides several potential targets that can be utilized for therapeutic intervention.

Asthma is a chronic obstructive respiratory disease that afflicts millions of people worldwide. A number of both genetic and environmental factors may contribute to asthma. Structural changes in the airways, known as airway remodeling, is a crucial pathological feature of asthma which may lead to lung function decline in severe disease. Little is known about the factors and mechanisms that drive airway remodeling and there are no curative or management interventions available for airway remodeling. Kumawat has  investigated the molecular mechanisms involved in airway remodeling with a particular focus on WNT signaling.

WNT signaling is involved in development of organs including the lungs and is also implicated in several diseases such as cancer and fibrosis. Kumawat  investigated the role of WNT signaling in regulating the features of airway remodeling. Using airway smooth muscles obtained from asthma patients, he  found that WNT-5A, a WNT protein, is highly increased in these cells. Further investigation revealed that WNT-5A regulates the expression of extracellular matrix and contractile proteins in airway smooth muscle cells. An altered profile of extracellular matrix and contractile proteins is a feature of remodeled airways in asthma subjects. Using a mouse model of chronic allergen induced airway inflammation, Kumawat found that WNT signaling is extensively modulated in the lungs. Of note, a WNT pathway inhibitor, WNT inhibitory factor 1 was found reduced in the lungs of allergen challenged animals.

Last modified:11 February 2015 8.08 p.m.
View this page in: Nederlands

More news

  • 11 December 2023

    Join the 'Language and AI' community

    As a part of the Jantina Tammes School, the 'Language and AI' theme is an interdisciplinary initiative that aims to encourage collaboration among academics, PhD candidates, students, and industry representatives who share a keen interest in the...

  • 13 October 2023

    Moniek Tromp appointed Captain of Science of the Top Sector Chemistry

    Prof. Moniek Tromp has been appointed Captain of Science of the Chemistry Top Sector by the Minister of Economic Affairs and Climate Policy. As from 1 July 2023, she succeeded Prof. Bert Weckhuysen from Utrecht University.

  • 12 September 2023

    Art in times of AI

    Leonardo Arriagada Beltran conducted his PhD research on the interface of computer-generated art and the constantly evolving field of Artificial Intelligence (AI). He will defend his Phd thesis on 21 September. His research offers valuable insights...