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Four GRIP thesis defences

27 October 2014

October 24, 2014 four PhD students from the Groningen research Institute of Pharmacy (GRIP) have defended their thesis. Graduation of so many students at the same day is an exceptional event and we are proud of graduates an staff who worked hard for realisation.

Precision-cut intestinal slices as an ex vivo model to study NSAID-induced intestinal toxicity

PhD ceremony:           X. Niu, MSc

Promotor:                  prof. dr. G.M.M. (Geny) Groothuis

The research of Xiaoyu Niu proved that precision cut intestinal slices (PCIS) are an unique intestinal ex vivo model, which contains all the intestinal cell types in their natural matrix, and maintains high activities of metabolic enzymes and transporters.

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Adhesive mixtures for inhalation

PhD ceremony:           F. Grasmeijer, MSc

Promotor:                  prof. dr. H.W. (Erik) Frijlink

The research of Floris Grasmeijer enables the development of adhesive mixtures that are better dispersible, so that asthma and COPD can be treated more effectively and safely by dry powder inhalation.

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β3-Adrenoceptor detection and signal transduction

PhD ceremony:           Ms H. Cernecka

Promotors:                 prof. dr. M. (Martina) Schmidt, M. Michel, H. Maarsingh

Černecká and her co-authors provided evidence about the molecular mechanisms involved in the relaxation induced by activation of β3-adrenoceptors in the urinary bladder of rats and humans. Importantly, β3-adrenoceptor activation was found to have stronger effects against stimuli occurring in diseased than in healthy bladder. Moreover, specific antibodies raised against β3-adrenoceptors were identified and validated for detection in human and rodent tissues.

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Rational use of Jatropha curcas L. in food and medicine

PhD ceremony:           Mr M. Insanu

Promotors:                 prof. dr. W.J. (Wim) Quax, prof. dr. O. (Oliver) Kayser

Jatropha curcas L. is a natural source of biodiesel. It has high potential economic values. Different parts of J. curcas have their own potencies, unfortunately these were not known by the farmers. The aim of the thesis of Muhamed Insanu is to give an overview of the additional values of Jatropha curcas L. by characterization of its natural products that can be used as a safe pharmaceutical product.

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