Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Impact of varying metal ion- and carbohydrate concentrations on gene expression in the human pathogen Streptococcus pneumoniae

26 October 2012

PhD ceremony: Mr. S. Shafeeq, 14.30 uur, Academiegebouw, Broerstraat 5, Groningen

Dissertation: Impact of varying metal ion- and carbohydrate concentrations on gene expression in the human pathogen Streptococcus pneumoniae

Promotor(s): prof. O.P. Kuipers

Faculty: Mathematics and Natural Sciences

The research of Sulman Shafeeq describes the impact of varying metal ions- and carbohydrate concentrations on gene expression of human pathogen Streptococcus pneumoniae. The most important conclusion of his research is varying concentration of metal ions especially Zinc has huge impact on the virulence gene expression of S. pneumoniae. Therefore Shafeeq thinks that metal ions, especially zinc, can be used for therapy, when given in appropriate concentrations.

Streptococcus pneumoniae is a Gram-positive human pathogen that is responsible for millions of deaths each year especially in children and the elderly, due to causing infections like pneumonia, meningitis, otitis media and sepsis. Little is known about the interaction of this human pathogen with and its behavior in the fluctuating nutritional environment inside the human body. The thesis of Shafeeq describes several gene regulatory responses of S. pneumoniae to varying metal ion- and carbohydrate availability, which it is likely to encounter in different niches inside the human body during the infection process. Several transcriptional regulators responsive to various metals (e.g. zinc and copper) and carbohydrate sources (e.g. cellobiose) are characterized by him and their regulons are studied in detail. The results described in his thesis will help to better understand the molecular biology of S. pneumoniae by providing new insights into the responses of S. pneumoniae to changing environmental conditions.

Last modified:15 September 2017 3.41 p.m.
printView this page in: Nederlands

More news

  • 25 June 2019

    Full speed ahead towards a green university

    Dick Jager isn’t one to give up easily. Since the late 1990s, he has been working to make the University of Groningen more sustainable. His journey has been a struggle, with the road often peppered with obstacles. But now things are going his way....

  • 21 June 2019

    Spinoza Prize 2019 for astronomer Amina Helmi

    Amina Helmi, a professor of Astronomy specializing in Milky Way dynamics, structure and formation, will receive the Spinoza Prize in October.

  • 21 June 2019

    Van Rijn’s multi-million euro reduction disastrous for UG

    The Cabinet’s decision, based on the advice of the Van Rijn committee, will have disastrous consequences for the University of Groningen as a broad-based classical university.