Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Lysine based amorphous polyurethanes decorated with pendant bio-active groups

19 October 2012

PhD ceremony: Ms. J. Yin, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen

Dissertation: Lysine based amorphous polyurethanes decorated with pendant bio-active groups

Promotor(s): prof. J.A. Loontjens

Faculty: Mathematics and Natural Sciences

Due to a wide range of physical and chemical properties, polyurethanes (PUs) are used in numerous applications like coatings, foams, fibers, engineering plastics and biomaterials. The use of biomaterials for medical implants is rapidly growing due to the aging of the world population and because it is not accepted anymore to live with loss of function due to trauma or wear. Depending on the composition, polyurethanes can fulfill all these requirements and have to be selected accordingly. It is convenient to synthesize polyurethanes from diisocyanates (DIs) since the DIs are reactive towards alcohols at low temperature, when catalyzed, and with amines without catalysts. However, the high reactivity and toxicity of isocyanates do not allow contamination of the body by traces of remnant. Temporarily blocking the isocyanate groups could be an attractive alternative, while still affording the same polyurethanes with polyols. They are less reactive and therefore possibly suitable to introduce bio-active moieties. My project studies the synthesis of linear or crosslinked polyurethanes from caprolactam blocked lysine diisocyanate (BLDI), which were provided with functional side groups. A novel synthetic methodology to prepare BLDI was developed. By making use of the expected stability of BLDI and the presence of a pendant ester group, the introduction bio-functional side groups like GRGDG and biotin via that pendant ester group was studied. Amorphous polymer networks were studied to avoid the presence of remnant polymer crystals after degradation. Some preliminary experiments with human cells were employed to demonstrate the biocompatibility of the resulting polyurethanes.

Last modified:15 September 2017 3.42 p.m.
printView this page in: Nederlands

More news

  • 22 May 2019

    Noord-Nederland gaat down under tijdens Solar Challenge

    Studenten van de Hanzehogeschool Groningen, Rijksuniversiteit Groningen en Noorderpoort gaan met hun eigen gebouwde zonneauto voor de eerste keer meedoen aan de Bridgestone World Solar Challenge (BWSC) in Australië onder de naam Top Dutch Solar Racing...

  • 20 May 2019

    Forthcoming honorary doctor Titia de Lange: Splicing ropes and aging

    Titia de Lange has dedicated most of her working life to researching long telomeres – the ends of chromosomes. She was awarded an honorary doctorate in June for her ground-breaking research. De Lange’s first experiment as a PhD student, under the supervision...

  • 17 May 2019

    "Worms man" Dr. Jeroen Onrust wins Science Prize Campus Fryslân 2019

    Bioloog Jeroen Onrust mag zich de winnaar noemen van de Wetenschapsprijs Campus Fryslân 2019. Onrust onderzocht voor zijn promotieonderzoek bij Rijksuniversiteit Groningen/Campus Fryslân het belang van regenwormen op de vruchtbaarheid van agrarisch...